The problem of infections associated with implants – an overview - Publication - MOST Wiedzy


The problem of infections associated with implants – an overview


Implant-associated infections are serious and relatively common complication that leads to implant loss. The purpose of this paper is to gather knowledge about this issue. A literature review of the epidemiology, risk factors and pathogenesis of infections related to implants was carried out. This position collects data on commonly used implants and infections associated with them from various fields of medicine and contains classifications of the main factors that predispose to this infection, frequency hierarchy and categorization of bacteria strain that cause them. The risk factors are grouped into four basic groups dependent on: the implant, the patient, the local environment and the surgical technique. It was found that this infections are the most common in the case of: ventricular assist devices, catheters, bone substitutes, dental and breast implants. The conclusion was made that implant-associated infections are usually caused by multiple strains of bacterial species, mainly by Staphylococci, especially Staphylococcus aureus and Staphylococcus epidermidis. The most important aspect of minimizing implant-associated infections is prevention. Summarize, besides of perioperative antibiotic prophylaxis, sterility of treatment and hygiene, the crucial aspect is also the design of implants.


artykuły w czasopismach recenzowanych i innych wydawnictwach ciągłych
Published in:
European Journal of Medical Technologies pages 19 - 26,
ISSN: 2353-1029
Publication year:
Bibliographic description:
Wekwejt M., Dziaduszewska M., Pałubicka A.: The problem of infections associated with implants – an overview// European Journal of Medical Technologies. -., nr. 4(21) (2018), s.19-26
Bibliography: test
  1. Chapter in the book: Stoodley P, Hall-Stoodley L, Costerton B, et al. Biofilms, Biomaterials, and Device-Related Infections. In: Modjarrad K, Ebne- sajjad S, ed. Handbook of Polymer Applications in Medicine and Medical Devices, William Andrew Publishing 2013: 77-101. open in new tab
  2. Schierholz JM, Beuth J. Implant infections: a ha- ven for opportunistic bacteria. J Hosp Infect 2001;49:87-93. open in new tab
  3. Oliveira WF, Silva PMS, Silva RCS, et al. Staphylo- coccus aureus and Staphylococcus epidermidis infections on implants. J Hosp Infect 2018; 98: 111-117. open in new tab
  4. Doll K, Jongsthaphongpun KL, Stumpp NS, et al. Quantifying implant-associated biofilms: Com- parison of microscopic, microbiologic and bio- chemical methods. J Microbiol Methods 2016; 130: 61-68. open in new tab
  5. Wekwejt M, Moritz N, Świeczko-Żurek B, Pałubicka A. Biomechanical testing of bioactive bone ce- ments -a comparison of the impact of modifiers: antibiotics and nanometals. Polym Test 2018; 70: 234-243. open in new tab
  6. Xing R, Lyngstadaas SP, Ellingsen JE, et al. The in- fluence of surface nanoroughness, texture and chemistry of TiZr implant abutment on oral bio- film accumulation. Clin Oral Implants Res 2015; 26: 649-656. open in new tab
  7. Copyright © 2018 by ISASDMT
  8. Han A, Tsoi JKH, Rodrigues FP, et al. Bacterial adhe- sion mechanisms on dental implant surfaces and the influencing factors. Int J Adhes Adhes 2016; 69: 58-71. open in new tab
  9. Shah SR, Tatara AM, D'Souza RN, et al. Evolving strategies for preventing biofilm on implantable materials, Mater Today 2013; 16: 177-182. open in new tab
  10. Lin HY, Liu Y, Wismeijer D, et al. Effects of oral im- plant surface roughness on bacterial biofilm for- mation and treatment efficacy. Int J Oral Maxillo- fac Implants 2012; 28: 1226-1231.
  11. Sánchez FR, Andrés CR, Arteagoitia I. Which anti- biotic regimen prevents implant failure or infec- tion after dental implant surgery? A systematic review and meta-analysis. J Craniomaxillofac Surg 2018; 46: 722-736.
  12. Park KC, Lim SJ, Song YS, et al. Factors affecting peri-implant fracture following locking plate for osteoporotic distal femur fractures. Orthop Trau- matol Surg Res 2017; 103: 1201-1204. open in new tab
  13. Morgenstern M, Erichsen C, von Rüden C, et al. Staphylococcal orthopaedic device-related infec- tions in older patients. Injury 2016; 47: 1427-1434. open in new tab
  14. Wu YTY, Willcox M, Zhu H, et al. Contact lens hy- giene compliance and lens case contamination: A review. Cont Lens Anterior Eye 2015; 38: 307-316. open in new tab
  15. Mittal S, Shaw RE, Michel K, et al. Cardiac implant- able electronic device infections: Incidence, risk factors, and the effect of the AigisRx antibacterial envelope. Heart Rhythm 2014; 11: 595-601. open in new tab
  16. Baek SH. Identification and preoperative optimi- zation of risk factors to prevent periprosthetic joint infection. World J Orthop 2014; 5: 362-367. open in new tab
  17. Ponce NA, Oladeji LO, Raley JA, et al. Analysis of perioperative morbidity and mortality in shoulder arthroplasty patients with preexisting alcohol use disorders. J Shoulder Elbow Surg 2015; 24: 167-173. open in new tab
  18. Deny A, Loiez C, Deken V, et al. Epidemiology of patients with MSSA versus MRSA infections of orthopedic implants: Retrospective study of 115 patients. Orthop Traumatol Surg Res 2016; 102: 919-923. open in new tab
  19. Bauer TW, Zhang Y: Implants and implant reac- tions. Diagn Histopathol 2016;22:384-396. open in new tab
  20. Campoccia D, Montanaro L, Arciola CR. The signifi- cance of infection related to orthopedic devices and issues of antibiotic resistance. Biomaterials 2006; 27: 2331-2339. open in new tab
  21. Jamal M, Ahmad W, Andleeb S, et al. Bacterial bio- film and associated infections. Chin Med J 2018; 81: 7-11. open in new tab
  22. Aghaloo TL, Mardirosian M, Delgado B. Controver- sies in Implant Surgery. Oral Maxillofac Surg Clin Noirth Am 2017; 29: 525-535. open in new tab
  23. Meijer ST, Pereira NRP, Nota SPF, et al. Factors asso- ciated with infection after reconstructive shoulder surgery for proximal humerus tumors. J Shoulder Elbow Surg 2017; 26: 931-938. open in new tab
  24. Weale R, El-Bakri F, Saeed K. Pre-operative asymp- tomatic bacteriuria: a risk factor for prosthetic joint infection?. J Hosp Infect 2018 /in press/. open in new tab
  25. Metsemakers WJ, Kortram K, Morgenstern M, et al. Definition of infection after fracture fixation: A systematic review of randomized controlled tri- als to evaluate current practice. Injury 2018; 49: 497-504. open in new tab
  26. Montanaro L, Speziale P, Campoccia D, et al. Scen- ery of Staphylococcus implant infections in ortho- pedics. Future Microbiol 2011; 6: 1329-1349. open in new tab
  27. Hogg ME, Peterson BG, Pearce WH, et al. Bare met- al stent infections: Case report and review of the literature. J Vasc Surg 2007; 46: 813-820. open in new tab
  28. Lodhia JV, Evans BJ. Heart valve surgery. Surgery 2018; 36: 75-82. open in new tab
  29. Mehrabi Bahar M, Jabbari Nooghabi A, Jabbari Nooghabi M., et al. The role of prophylactic ce- fazolin in the prevention of infection after various types of abdominal wall hernia repair with mesh.
  30. Asian J Surg 2015; 38: 139-144. open in new tab
  31. Guillaume O, Pérez-Tanoira R, Fortelny R, et al. In- fections associated with mesh repairs of abdomi- nal wall hernias: Are antimicrobial biomaterials the longed-for solution?. Biomaterials 2018; 167: 15-31. open in new tab
  32. Hussein AA, Baghdy Y, Wazni OM, et al. Microbiolo- gy of Cardiac Implantable Electronic Device Infec- tions. JACC: Clin Electrophysiol 2016; 2: 498-505. open in new tab
  33. Stamler JF. The complications of contact lens wear. Curr Opin Ophthalmol 1998; 9: 66-71. open in new tab
  34. Mankin HJ, Hornicek FJ, Raskin KA. Infection in massive bone allografts. Clin Orthop Relat Res 2005; 432: 210-216. open in new tab
  35. Vila PM, Ghogomu NT, Odom-John AR, et al. Infec- tious complications of pediatric cochlear implants are highly influenced by otitis media. Int J Pediatr Otorhinolaryngol 2017; 97: 76-82. open in new tab
  36. Copyright © 2018 by ISASDMT
  37. Franchell S, Pesce M, Baldelli I, et al. Analysis of clinical management of infected breast implants and of factors associated to successful breast pocket salvage in infections occurring after breast reconstruction. Int J Infect Dis 2018; 71: 67-72. open in new tab
  38. Pałubicka A, Wekwejt M, Świeczko-Żurek B, Zieliń- ski J. Powikłania po rekonstrukcji piersi: problem zakażeń i strategii prewencyjnej -przegląd litera- turowy. Chirurgia Plastyczna i Oparzenia. 2017; 5: 89-97. open in new tab
  39. Santarpia L, Buonomo A, Pagano MC, et al. Central venous catheter related bloodstream infections in adult patients on home parenteral nutrition: prev- alence, predictive factors, therapeutic outcome. open in new tab
  40. Clin Nutr 2016; 35: 1394-1398. open in new tab
  41. Parra-Flores M, Souza-Gallardo LM, García-Correa GA, et al. Incidence of catheter-related infection incidence and risk factors in patients on total par- enteral nutrition in a third level hospital. Cir Cir 2017; 85: 104-108. open in new tab
  42. Pye AD, Lockhart DEA, Dawson MP. A review of dental implants and infection. J Hosp Infect 2009; 72: 104-110. open in new tab
  43. Berglundh T, Persson L, Klinge B. A systematic review of the incidence of biological and techni- cal complications in implant dentistry reported in prospective longitudinal studies of at least 5 years. J Clin Periodontol 2002; 29: 197-212. open in new tab
  44. Mombelli A, Müller N, Cionca N. The epidemiology of peri-implantitis. Clin. Oral Implants Res 2012; open in new tab
  45. Mankin HJ, Hornicek FJ, Raskin KA. Infection in massive bone allografts. Clin. Orthop. Relat. Res., 432 (2005), pp. 210-216 open in new tab
  46. Flores-Mireles AL, Walker JN, Caparon M, et al. Uri- nary tract infections: Epidemiology, mechanisms of infection and treatment options. Nat Rev Micro- biol 2015; 13: 269-284. open in new tab
  47. Schulte-Eistrup S, Reiss N, Schmidt T, et al. Greater Omentum Wrapping to Treat Systemic Ventricular Assist Device Infections. Oper Tech Thorac Cardio- vasc Surg 2017; 22: 186-197. open in new tab
  48. Joost I, Bothe W, Pausch C, Staphylococcus aureus bloodstream infection in patients with ventricular assist devices-Management and out- come in a prospective bicenter cohort. J Infec 2018; 77: 30-37. open in new tab
  49. Al Mohajer M, Darouiche RO. Infections Associat- ed with Inflatable Penile Prostheses. Sex Med Rev 2014; 2: 134-140. open in new tab
  50. Peter M. Vila, Nsangou T. Ghogomu, Audrey R.
  51. Odom-John, Timothy E. Hullar, Keiko Hirose, Infec- tious complications of pediatric cochlear implants are highly influenced by otitis media, Interna- tional Journal of Pediatric Otorhinolaryngology, Volume 97, 2017, Pages 76-82
  52. Arciola CA, Campoccia D, Speziale P, et al. Biofilm formation in Staphylococcus implant infections. A review of molecular mechanisms and implica- tions for biofilm-resistant materials. Biomaterials 2012; 33: 5967-5982. open in new tab
  53. Bartmanski M, Cieslik B, Glodowska J, et al. Elec- trophoretic deposition (EPD) of nanohydroxyapa- tite -nanosilver coatings on Ti13Zr13Nb alloy. Ce- ram Int. 2017; 43: 11820-11829, 49. Michalska-Sionkowska M, Kaczmarek B, Sionkow- ka A, et al. Antimicrobial activity of new materials based on the blends of collagen/chitosan/hyal- uronic acid with gentamicin sulfate addition. Ma- ter Sci Eng 2018; 86: 103-108. open in new tab
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