Search
Trimethylamine N-oxide and the reverse cholesterol transport in cardiovascular disease: a cross-sectional study
Abstract
The early atherosclerotic lesions develop by the accumulation of arterial foam cells derived mainly from cholesterol-loaded macrophages. Therefore, cholesterol and cholesteryl ester transfer protein (CETP) have been considered as causative in atherosclerosis. Moreover, recent studies indicate the role of trimethylamine N-oxide (TMAO) in development of cardiovascular disease (CVD). The current study aimed to investigate the association between TMAO and CETP polymorphisms (rs12720922 and rs247616), previously identified as a genetic determinant of circulating CETP, in a population of coronary artery disease (CAD) patients (n = 394) and control subjects (n = 153). We also considered age, sex, trimethylamine (TMA) levels and glomerular filtration rate (GFR) as other factors that can potentially play a role in this complex picture. We found no association of TMAO with genetically determined CETP in a population of CAD patients and control subjects. Moreover, we noticed no differences between CAD patients and control subjects in plasma TMAO levels. On the contrary, lower levels of TMA in CAD patients respect to controls were observed. Our results indicated a significant correlation between GFR and TMAO, but not TMA. The debate whether TMAO can be a harmful, diagnostic or protective marker in CVD needs to be continued.
Citations
-
2 8
CrossRef
-
0
Web of Science
-
2 1
Scopus
Authors (9)
-
Laura Bordoni
-
Joanna J. Samulak
-
Angelika K. Sawicka
-
Iwona Pelikant-Malecka
-
Adrianna Radulska
-
Lukasz Lewicki
-
Rosita Gabbianelli
-
Robert Olek dr hab.
Cite as
Full text
- Publication version
- Accepted or Published Version
- DOI:
- Digital Object Identifier (open in new tab) 10.1038/s41598-020-75633-1
- License
-
open in new tab
Keywords
Details
- Category:
- Articles
- Type:
- artykuły w czasopismach
- Published in:
-
Scientific Reports
no. 10,
ISSN: 2045-2322 - Language:
- English
- Publication year:
- 2020
- Bibliographic description:
- Bordoni L., Samulak J. J., Sawicka A. K., Pelikant-Malecka I., Radulska A., Lewicki L., Kalinowski L., Gabbianelli R., Olek R.: Trimethylamine N-oxide and the reverse cholesterol transport in cardiovascular disease: a cross-sectional study// Scientific Reports -Vol. 10,iss. 1 (2020), s.18675-
- DOI:
- Digital Object Identifier (open in new tab) 10.1038/s41598-020-75633-1
- Verified by:
- Gdańsk University of Technology
seen 70 times
Recommended for you
Mitochondrial DNA copy number and trimethylamine levels in the blood: New insights on cardiovascular disease biomarkers
- L. Bordoni,
- I. Petracci,
- I. Pelikant-Malecka
- + 7 authors
Gender-Related Differences in Trimethylamine and Oxidative Blood Biomarkers in Cardiovascular Disease Patients
- L. Bordoni,
- D. Fedeli,
- M. Piangerelli
- + 8 authors