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Unraveling Energy Transfer and Fluorescence Quenching Dynamics in Biomolecular Complexes: A Comprehensive Study of Imiquimod-Rifampicin Interaction.
Abstract
In nature, numerous biomolecules are implicated in charge transfer (CT) and energy transfer (ET) mechanisms crucial for fundamental processes such as photosynthesis. Unveiling these mechanisms is pertinent to multiple disciplines including chemistry, engineering and biochemistry. This letter presents a study involving two molecules forming a model system with efficient ET properties. Specifically, their complex exhibits dark quenching phenomena arising from fluorescence resonance energy transfer (FRET) from the donor (imiquimod) to the acceptor (rifampicin). Supplemented by experimental findings, molecular dynamics simulations and time dependent density functional theory (TD-DFT) calculations conclusively validate the ET properties from the donor to the acceptor as described above
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Authors (6)
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Sudhanshu Sharma
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Dineshbabu Takkella
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Krishna Gavvala
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Details
- Category:
- Articles
- Type:
- artykuły w czasopismach dostępnych w wersji elektronicznej [także online]
- Published in:
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PHYSICAL CHEMISTRY CHEMICAL PHYSICS
ISSN: 1463-9076 - Language:
- English
- Publication year:
- 2024
- Bibliographic description:
- Sharma S., Takkella D., Srivastava A., Czub J., Sappati S., Gavvala K., Unraveling Energy Transfer and Fluorescence Quenching Dynamics in Biomolecular Complexes: A Comprehensive Study of Imiquimod-Rifampicin Interaction., PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2024,10.1039/D4CP02732A
- DOI:
- Digital Object Identifier (open in new tab) 10.1039/d4cp02732a
- Sources of funding:
-
- Free publication
- Verified by:
- Gdańsk University of Technology
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