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Search results for: CANCER STEM CELLS
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In vitro substance P-dependent induction of bone marrow cells in common (CD10) acute lymphoblastic leukaemia
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Characterization and cytotoxic effect of aqua-(2,2′,2′′-nitrilotriacetato)-oxo-vanadium salts on human osteosarcoma cells
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Selected extracts from Potentilla alba modulate the viability of normal and cancerous cells of the human colon epithelium
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Emerging Role of Adenylate Kinase 4 as a Metabolic Player Regulating Cellular Hypoxic Responses in Pulmonary Cells
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Potentilla alba Extracts Affect the Viability and Proliferation of Non-Cancerous and Cancerous Colon Human Epithelial Cells
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In Vitro Anticancer Potential of Jasione montana and Its Main Components against Human Amelanotic Melanoma Cells
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The Potential Mechanism of Tiliroside-Dependent Inhibition of t-Butylhydroperoxide-Induced Oxidative Stress in Endometrial Carcinoma Cells
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Selected metrological aspects of permeation cells used for testing the resistance of polymeric materials to penetration by liquid chemicals
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Trans-endocardial delivery of progenitor cells to compromised myocardium using the “needle technique”and risk of myocardial injury
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LY294002 and sorafenib as inhibitors of intracellular survival pathways in the elimination of human glioma cells by programmed cell death
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Unveiling the Electrocatalytic Activity of the GdBa0.5Sr0.5Co2–xCuxO5+δ (x ≥ 1) Oxygen Electrodes for Solid Oxide Cells
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Tailoring the Stability of Ti-Doped Sr2Fe1.4TixMo0.6−xO6−δ Electrode Materials for Solid Oxide Fuel Cells
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Sequential induction of mitotic catastrophe followed by apoptosis in human leukemia MOLT4 cells by imidazoacridinone C-1311
PublicationWykazano, że pochodna imidazoakrydonu C-1311 indukuje zahamowanie progresji komórek MOLT4 w fazie G2M cyklu życiowego. Podwyższona ekspresja fosfoepitopu MPM-2 przy jednoczesnym zaniku ufosforylowanej formy Tyr15-cdc2 wskazywała, iż komórki początkowo zablokowane w fazie G2 przechodziły do mitozy. Jednocześnie na skutek nieprawidłowego przebiegu mitozy komórki ulegały katastrofie mitotycznej. Analiza biochenicznych markerów apoptozy...
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Antitumour imidazoacridone C-1311 induces cell death by mitotic catastrophe in human colon carcinoma cells
PublicationW przedstawionych badaniach określano mechanizm śmierci komórkowej indukowanej przez imidazoakrydon C-1311 (Symadex) w komórkach HT-29 ludzkiego raka jelita grubego, które wykazywały szczególną wrażliwość na ten związek w eksperymentalnych modelach in vitro i in vivo. Przy stężeniu odpowiadającemu dawce IC99, związek powodował zahamowanie progresji cyklu komórkowej w fazie S po czym następował blok w fazie G2. Po czasach 48-96...
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Influence of G2 arrest on the cytotoxicity of DNA topoisomerase inhibitorstoward human carcinoma cells with different p53 status
PublicationRola bloku G2 w efekcie cytotoksycznym inhibitorów DNA topoizomeraz w stosunku do ludzkich komórek rakowych różniących się funkcjonalnością białka p53.
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NICKEL-BASED LAYERED PEROVSKITE CATHODE MATERIALS FOR APPLICATION IN INTERMEDIATE-TEMPERATURE SOLID OXIDE FUEL CELLS
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The effect of interleukin-35 on the integrity, ICAM-1 expression and apoptosis of human aortic smooth muscle cells
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Photophysical properties and photocytotoxicity of free and liposome-entrapped diazepinoporphyrazines on LNCaP cells under normoxic and hypoxic conditions
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CGB and GNRH1 expression analysis as a method of tumor cells metastatic spread detection in patients with gynecological malignances
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Crystalline Silicon (c-Si)-Based Tunnel Oxide Passivated Contact (TOPCon) Solar Cells: A Review
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Dyes based on the D/A-acetylene linker-phenothiazine system for developing efficient dye-sensitized solar cells
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Chemical treatment of crystalline silicon solar cells as a method of recovering pure silicon from photovoltaic modules
PublicationProducenci modułów PV stosują ogniwa krzemowe, wyprodukowane w różnej technologii, w efekcie czego różnią się one między sobą. Różnorodność dotyczy zarówno modułów PV, wykonanych z ogniw polikrystalicznych jak i monokrystalicznych. Różnice widoczne są zwłaszcza dla kontaktów elektrycznych. Producenci ogniw wykonują metalizację z zastosowaniem past Al, Ag lub przy jednoczesnym użyciu Al/Ag. Proces recyklingu krzemowych ogniw PV...
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The antitumor derivatives, C1305 and C1748, were different in effects on CYP3A4 expression and catalytic activity in HepG2 cells
PublicationCytochromy P450 (CYP) należą do grupy enzymów biorących udział w 70-80% metabolizmu fazy I większości stosowanych klinicznie leków. Z tego powodu oddziaływanie leków z enzymami cytochromu P450 stało się istotnym elementem w projektowaniu chemoterapeutyków, szczególnie tych, które są stosowane w terapii wielolekowej. Znajomość substratów, induktorów i inhibitorów poszczególnych izoenzymów P450, nie tylko może obniżać częstość występowania...
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Spliced analogues of trypsin inhibitor SFTI‐1 and their application for tracing proteolysis and delivery of cargos inside the cells
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On the tendency of temperature and electric field dependences of interface recombination in P3HT:PCBM organic bulk heterojunction solar cells
PublicationWe demonstrate theoretical explanation of the temperature and electric field dependences of recombination coefficients in an organic P3HT:PCBM bulk heterojunction solar cell. Based onthe model of interface recombination, two analytical formulas describing the relative ratio of the interface (γI ) to the Langevin (γL) recombination coefficients have been derived. Our analysis indicates that the sign of parameters φT and φF determines...
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Data analysis of FTIR spectra for study of outlet gases of Solid Oxide Fuel Cells fuelled by biogas
PublicationW pracy przedstawiono system umożliwiający połączenie spektroskopii FTIR z specjalnie zaprojektowanym oprogramowaniem w celu uzyskania informacji o stężeniach gazów wylotowych z ogniw paliwowych SOFC. Przebadane zostały główne produkty reformingu biogazu: tlenek węgla, dwutlenek węgla, metan oraz wodór. Opisane oprogramowanie umożliwia w prosty i szybki sposób uzyskanie informacji o gazach wylotowych ogniwa paliwowego.
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Tuning Electrochemical Performance by Microstructural Optimization of the Nanocrystalline Functional Oxygen Electrode Layer for Solid Oxide Cells
PublicationFurther development of solid oxide fuel cell (SOFC) oxygen electrodes can be achieved through improvements in oxygen electrode design by microstructure miniaturisation alongside nanomaterials implementation. In this work, improved electrochemical performance of an La0.6Sr0.4Co0.2Fe0.8O3-d (LSCF) cathode was achieved by the controlled modification of the La0.6Sr0.4CoO3-d (LSC) nanocrystalline interlayer introduced between a porous...
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Recent advances in 3D bioprinted tumor models for personalized medicine
PublicationCancerous tumors are among the most fatal diseases worldwide, claiming nearly 10 million lives in 2020. Due to their complex and dynamic nature, modeling tumors accurately is a challenging task. Current models suffer from inadequate translation between in vitro and in vivo results, primarily due to the isotropic nature of tumors and their microenvironment's relationship. To address these limitations, hydrogel-based 3D bioprinting...
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Pregnane X receptor dependent up-regulation of CYP2C9 and CYP3A4 in tumor cells by antitumor acridine agents, C-1748 and C-1305, selectively diminished under hypoxia
PublicationInduction of proteins involved in drug metabolism and in drug delivery has a significant impact on drug-drug interactions and on the final therapeutic effects. Two antitumor acridine derivatives selected for present studies, C-1748 (9-(2’-hydroxyethylamino)-4-methyl-1-nitroacridine) and C-1305 (5-dimethylaminopropylamino-8-hydroxy-triazoloacridinone), expressed high and low susceptibility to metabolic transformations with liver...
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Comparative analysis of mechanical conditions in bone union following first metatarsophalangeal joint arthrodesis with varied locking plate positions: A finite element analysis
PublicationFirst metatarsophalangeal joint arthrodesis is a typical medical treatment performed in cases of arthritis or joint deformity. The gold standard for this procedure is arthrodesis stabilisation with the dorsally positioned plate. However, according to the authors’ previous studies, medially positioned plate provides greater bending stiffness. It is worth to compare the mechanical conditions for bone formation in the fracture callus...
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In Vitro and In Vivo Imaging-Based Evaluation of Doxorubicin Anticancer Treatment in Combination with the Herbal Medicine Black Cohosh
PublicationAs a substitution for hormone replacement therapy, many breast cancer patients use black cohosh (BC) extracts in combination with doxorubicin (DOX)-based chemotherapy. In this study, we evaluated the viability and survival of BC- and DOX-treated MCF-7 cells. A preclinical model of MCF-7 xenografts was used to determine the influence of BC and DOX administration on tumor growth and metabolism. The number of apoptotic cells after...
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From tryptophan to novel mitochondria-disruptive agent, synthesis and biological evaluation of 1,2,3,6-tetrasubstituted carbazoles
PublicationMitochondrial targeting plays an important role in anticancer therapy. The Mn(III)-promoted cyclization of 5- (1H-indol-3-yl)-3-oxopentanoic acid allow to obtain novel substituted carbazole derivatives that can act as mitochondria-disruptive agents. The starting materials used for the synthesis of these new aminocarbazoles are oxopentanoate derivatives of tryptophan. The scope and limitation of this method of synthesis are determined...
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Radiation damage of biomolecular systems: Nano-scale insights into Ion-beam cancer therapy. 2nd Nano-IBCT conference
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Mass spectrometry-based analysis of therapy-related changes in serum proteome patterns of patients with early-stage breast cancer
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OC-0265: Whole body response to radiation in head and neck and prostate cancer patient; the serum proteome comparative analysis
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Characteristic profiles of DNA epigenetic modifications in colon cancer and its predisposing conditions—benign adenomas and inflammatory bowel disease
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Biofilm Growth Causes Damage to Silicone Voice Prostheses in Patients after Surgical Treatment of Locally Advanced Laryngeal Cancer
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Expression of Osteoblast-Specific Factor 2 (OSF-2, Periostin) Is Associated with Drug Resistance in Ovarian Cancer Cell Lines
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PTPRK Expression Is Downregulated in Drug Resistant Ovarian Cancer Cell Lines, and Especially in ALDH1A1 Positive CSCs-Like Populations
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Deep Learning-based Recalibration of the CUETO and EORTC Prediction Tools for Recurrence and Progression of Non–muscle-invasive Bladder Cancer
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LC-PDA-MS and GC-MS Analysis of Scorzonera hispanica Seeds and Their Effects on Human Breast Cancer Cell Lines
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P3.13-032 The Impact of Tobacco Exposure on Lung Nodules and Emphysema in a Pilot Silesian Study of Early Lung Cancer with LDCT
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Validation of the Polish version of the EORTC QLQ-OV28 module for the assessment of health-related quality of life in women with ovarian cancer
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Discussion on 3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibitors reduce human pancreatic cancer cell invasion and metastasis
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Urine metabolic fingerprinting using LC–MS and GC–MS reveals metabolite changes in prostate cancer: A pilot study
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Metabolic Evaluation of Urine from Patients Diagnosed with High Grade (HG) Bladder Cancer by SPME-LC-MS Method
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Self-organizing maps classification of epidemiological data and toenail selenium content monitored on cancer and healthy patients from Poland
PublicationW pracy przedstawiono wyniki wielowymiarowej analizy danych pomiarowych (przy wykorzystaniu techniki samoorganizującej sie mapy (SOM))nad oszacowaniem zawartości selenu w próbkach paznokci pobranych od mieszkańców Województwa Pomorskiego ((w tym od grupy osób zdrowych i ze zdiagnozowaną chorobą nowotworową) i Lubuskiego. W wyniku przeprowadzonej analizy uzyskano podział uczestników ze zdiagnozowanym nowotworem na trzy różne grupy:1...
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CHEMOTHERAPY-MEDIATED COMPLICATIONS OF WOUND HEALING. AN UNDERSTUDIED SIDE EFFECT
PublicationSignificance: Chemotherapy is a primary method to treat cancer, but while cytotoxic drugs are designed to target rapidly dividing cancer cells, they can also affect other cell types, including dermal cells and macrophages involved in wound healing, which often leads to the development of chronic wounds. The situation becomes even more severe when chemotherapy is combined with surgical tumor excision. Recent advances: Despite its...
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Are Radiosensitive and Regular Response Cells Homogeneous in Their Correlations Between Copy Number State and Surviving Fraction After Irradiation?
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Expression Profile of Genes Regulating Steroid Biosynthesis and Metabolism in Human Ovarian Granulosa Cells—A Primary Culture Approach
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