Filters
total: 960
filtered: 725
Search results for: GENE-SWITCH THERAPY
-
Stability of delay induced oscillations in gene expression of Hes1 protein model
PublicationW pracy prezentowana jest matematyczna analiza modelu ekspresji genu białka Hes1. Rozważamy układ równań z dwoma opóźnieniami - w produkcji białka Hes1 oraz jego mRNA. Dowodzimy istnienia i jednoznaczności oraz nieujemności rozwiązań. Pokazujemy istnienie dokładnie jednego dodatniego stanu stacjonarnego. Wykazujemy, że stabilność stanu stacjonarnego zależy od sumy opóźnień. Podajemy warunek dostateczny na wystąpienie bifurkacji...
-
Vitamin D Metabolism Gene Polymorphisms and Their Associated Disorders: A Literature Review
Publication -
Clinical presentation of Y189C mutation of the NOTCH3 gene in the Polish family with CADASIL
Publication -
HPV16 E6 Gene Transcripts in Primary Type II Endometrial Carcinomas
Publication -
Technology of an adhesive silicone film as drug carrier in transdermal therapy I. Analytical methods used for characterization and design of the universal elastomer layers
PublicationSilicone polymers possess unique properties, which make them suitable for many different applications, for example in the pharmaceutical and medical industry. To create an adhesive silicone film, the appropriate silicone components have to be chosen first. From these components two layers were made: an adhesive elastomer applied on the skin, and a non-adhesive elastomer on the other side of the film. The aim of this study was...
-
Dual-task exercise as a therapy for executive motor function in Parkinson’s disease
Publication -
Effect of brefeldin A and castanospermine on resistant cell lines as supplements in anticancer therapy
Publication -
COVID-19: Is There Evidence for the Use of Herbal Medicines as Adjuvant Symptomatic Therapy?
Publication -
Inhibitory mikrotubul w terapii przeciwnowotworowej = Inhibitors of microtubule in cancer therapy
PublicationW artykule opisano inhibitory mikrotubul, różnorodne związki chemiczne, znajdujące się w zaawansowanych przedklinicznych i wstępnych badaniach klinicznych. Pośród nich na uwagę zasługują półsyntetyczne analogi taksolu, substancje pochodzenia naturalnego, takie jak: epotilony, kombretastatyny, kolchinoidy, dolastatyny oraz syntetyczne związki o niskim ciężarze czasteczkowym: heterokombretastatyny, sulfonamidy, fenostatyny, pochodne...
-
Effect of renal replacement therapy on selected arachidonic acid derivatives concentration
Publication -
Theophylline Therapy for Near-Fatal Cheyne–Stokes Respiration: A Case Report
Publication -
Radiation therapy dosimetry using magnetic resonance imaging of polymer gels
Publication -
Nurses and Pharmacists in Interdisciplinary Team of Health Care Providers in Photodynamic Therapy
Publication -
Antithrombotic therapy in patients with atrial fibrillation undergoing percutaneous coronary intervention
Publication -
Smart Pen - new multimodal computer control tool for graphomotorical therapy
PublicationW sytuacji, gdy około 15% populacji uczniów wykazuje cechy dyslektyczne, koniecznością staje się wyposażenie szkół w efektywne narzędzia do diagnozy i terapii tego rodzaju zaburzeń. Dzięki wykorzystaniu tabletu i specjalnie skonstruowanego długopisu wyposażonego w czujniki nacisku uzyskano możliwość monitorowania wielu parametrów, które do tej pory były dla terapeutów całkowicie niedostępne (np. pomiar nacisku na podłoże czy ścisku...
-
H2AX phosphorylation, its role in DNA damage response and cancer therapy
PublicationDouble-strand breaks (DSBs) are the most deleterious DNA lesions, which, if left unrepaired, may have severe consequences for cell survival, as they lead to chromosome aberrations, genomic instability, or cell death. Various physical, chemical, and biological factors are involved in DSB induction. Cells respond to DNA damage by activating the so-called DNA damage response (DDR), a complex molecular mechanism developed to detect...
-
A novel cold-active β-D-galactosidase with transglycosylation activity from the Antarctic Arthrobacter sp. 32cB - gene cloning, purification and characterization
PublicationA gene encoding a novel β-D-galactosidase from the psychrotolerant Antarctic bacterium Arthrobacter sp. 32cB was isolated, cloned and expressed in Escherichia coli. The active form of recombinant β-D-galactosidase consists of two subunits with a combined molecular weight of approximately 257 kDa. The enzyme's maximum activity towards o-nitrophenyl-β-D-galactopyranoside was determined as occurring at 28 °C and pH 8.0. However, it...
-
An MTA-phosphorylase gene discovered in the metagenomic library derived from Antarctic top soil during screening for lipolytic active clones confers strong pink fluorescence in the presence of rhodamine B.
PublicationIn this work, we present the construction of a metagenomic library in Escherichiacoli using the pUC19 vector and environmental DNA directly isolated fromAntarctic topsoil and screened for lipolytic enzymes. Unexpectedly, the screeningon agar supplemented with olive oil and rhodamine B revealed one unusual pinkfluorescent clone (PINKuv) out of 85 000 clones. This clone harbored a plasmid,pPINKuv, which has an insert of 8317 bp that...
-
A new cold-adapted beta-D-galactosidase from the Antarctic Arthrobacter sp. 32c - gene cloning, overexpression, purification and properties
PublicationThe development of a new cold-active β-D-galactosidases and microorganisms that efficiently ferment lactose is of high biotechnological interest, particularly for lactose removal in milk and dairy products at low temperatures and for cheese whey bioremediation processes with simultaneous bio-ethanol production. In this article, we present a new β-D-galactosidase as a candidate to be applied in the above mentioned biotechnological...
-
A new B-D-galactosidase with a low temperature optimum isolated from the Antarctic Arthrobacter sp. 20B: gene cloning, purification and characterization.
PublicationA psychrotrophic bacterium producing a coldadaptedB-galactosidase upon growth at low temperatureswas classiWed as Arthrobacter sp. 20B. A genomic DNAlibrary of strain 20B introduced into Escherichia coliTOP10F' and screening on X-Gal (5-bromo-4-chloro-3-indolyl-B-D-galactopyranoside)-containing agar plates ledto the isolation of B-galactosidase gene. The B-galactosidasegene (bgaS) encoding a protein of 1,053 amino acids,with a...
-
Prognostic Significance of TOP2A Gene Dosage in HER-2-Negative Breast Cancer
Publication -
Germline mutations in theCHEK2 kinase gene are associated with an increased risk of bladder cancer
Publication -
Gene set enrichment for reproducible science: comparison of CERNO and eight other algorithms
Publication -
Adaptive filtering of microarray gene expression data based on Gaussian mixture decomposition
Publication -
Proteins Structure Models in the Evaluation of Novel Variant (C.472_477del) in the MOCS2 Gene
Publication -
Optimised expression cassettes of hpt marker gene for biolistic transformation of Miscanthus sacchariflorus
Publication -
Association of ENAM gene single nucleotide polymorphisms with dental caries in Polish children
Publication -
The role of TGF superfamily gene expression in the regulation of folliculogenesis and oogenesis in mammals: a review
Publication -
Relationship between polymorphism in the CRH gene and the traits of body conformation of Salers cows
Publication -
The Relationship Between Gene Polymorphisms and Dipping Profile in Patients With Coronary Heart Disease
Publication -
The role of FNDC5 gene expression in irisin level changes accompanying thyroid pathologies
Publication -
Research Trends of Vitamin D Metabolism Gene Polymorphisms Based on a Bibliometric Investigation
Publication -
Cloning of the thermostable alpha-amylase gene from Pyrococcus woesei in Escherichia coli.
PublicationGen kodujący alfa-amylazę z Pyrococcus woesei klonowano do plazmidów pET21d(+)lub pYTB2, którymi transformowano komórki Escherichia coli. Otrzymana rekombinantowa alfa amylaza wykazuje maksymalną aktywność przy pH 5.6 w temperaturze 95 stC i przejawia około 24 % początkowej aktywności nawet po 2 godz. inkubacji w 120 stC. Duża termostabilność otrzymanego preparatu świadczy o jego przydatności do enzymatycznego upłynniania skrobi.
-
Relationship between Telomere Length, TERT Genetic Variability and TERT, TP53, SP1, MYC Gene Co-Expression in the Clinicopathological Profile of Breast Cancer
PublicationThe molecular mechanisms of telomerase reverse transcriptase (TERT) upregulation in breast cancer (BC) are complex. We compared genetic variability within TERT and telomere length with the clinical data of patients with BC. Additionally, we assessed the expression of the TERT, MYC, TP53 and SP1 genes in BC patients and in BC organoids (3D cell cultures obtained from breast cancer tissues). We observed the same correlation in the...
-
Multiple transcriptional factors regulate transcription of the rpoE gene in Escherichia coli under different growth conditions and when the lipopolysaccharide biosynthesis is defective.
PublicationThe RpoE sigma factor is essential for the viability of Escherichia coli. RpoE regulates extracytoplasmic functions including lipopolysaccharide (LPS) translocation and some of its non-stoichiometric modifications. Transcription of the rpoE gene is positively autoregulated by EσE and by unknown mechanisms that control the expression of its distally located promoter(s). Mapping of 5′ ends of rpoE mRNA identified five new transcriptional...
-
Therapy with CD4+CD25+ T regulatory cells – should we be afraid of cancer?
Publication -
Reasons for the discontinuation of therapy of personal insulin pump in children with type 1 diabetes
Publication -
Radiation Therapy-Induced Changes in Serum Lipidome of Head and Neck Cancer Patients
Publication -
Recent progress in the engineering of multifunctional colloidal nanoparticles for enhanced photodynamic therapy and bioimaging
Publication -
Serum MicroRNAs as Xerostomia Biomarkers in Patients With Oropharyngeal Cancer Undergoing Radiation Therapy
Publication -
The role of oat products in the prevention and therapy of type 2 diabetes, hypercholesterolemia and obesity
Publication -
Interactions of Bacteriophages with Animal and Human Organisms—Safety Issues in the Light of Phage Therapy
Publication -
Surfactant replacement therapy as promising treatment for COVID-19: an updated narrative review
Publication -
More is Less? Optimal Combination Therapy for Adequate Blood Pressure Lowering in Hypertension
Publication -
Possiblities of application of recombined lysostaphin as an alternative agent in the therapy of Staphylococcus aureus mastitis
Publication -
Photophysical properties and photocytotoxicity of novel phthalocyanines – potentially useful for their application in photodynamic therapy
Publication -
Potential application of pure silica optical flat fibers for radiation therapy dosimetry
Publication -
Investigating the disease‐modifying properties of sclerotiorin in Alzheimer's therapy using acetylcholinesterase inhibition
Publication -
Application of the laser diode with central wavelength 975 nm for the therapy of neurofibroma and hemangiomas
PublicationThis paper presents newly developed dermatological laser (with central wavelength 975 nm) for application in therapies requiring deep penetration of tissue, e.g. cutaneous (dermal) neurofibroma (Recklinghausen disease) and hemangiomas. This laser can work either in pulse or continues wave mode. Laser radiation is transmitted toward the application region by optical fiber with a diameter of 0.6 mm. The compact design of the laser...
-
Investigating the disease- modifying properties of sclerotiorin in Alzheimer's therapy using acetylcholinesterase inhibition
PublicationAlzheimer's disease (AD) is a progressive neurodegenerative disorder caused due to the damage and loss of neurons in specific brain regions. It is the most common form of dementia observed in older people. The symptoms start with memory loss and gradually cause the inability to speak and do day-to-day activities. The cost of caring for those affected individuals is huge and is probably beyond most developing countries capability....