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The impact of lipophilicity on environmental processes, drug delivery and bioavailability of food components
PublicationLipophilic properties of the compound allow to predict its fate in living organisms and to propose the models of chemicals transport and accumulation in the ecosystem. Lipophilicity is also useful as the characteristic of chemicals in respect to their optimal attributes for specific biological and non-biological tasks. The lipophilicity descriptors define the potency of endo- and xenobiotics to metabolic transformations and their...
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Role of miR-15b/16–2 cluster network in endometrial cancer: An in silico pathway and prognostic analysis
PublicationEndometrial cancer (EC) is the second most common cancer in women. A large number of human cancers exhibit dysregulation of microRNA expression including EC. MiR-15b/16–2 is one of the best-known miRNA clusters that is expressed in many types of cancer tissues. Herein, we analyzed the expression of individual miR-15b/16–2 cluster members, its paralogues, and their target network analysis, as well as their prognostic significance...
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An insight into the mixed quantum mechanical-molecular dynamics simulation of a ZnII-Curcumin complex with a chosen DNA sequence that supports experimental DNA binding investigations
PublicationAn important aspect of research pertaining to Curcumin (HCur) is the need to arrest its degradation in aqueous solution and in biological milieu. This may be achieved through complex formation with metal ions. For this reason, a complex of HCur was prepared with ZnII, that is not likely to be active in redox pathways, minimizing further complications. The complex is monomeric, tetrahedral, with one HCur, an acetate and a molecule...
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A New Double Digestion Ligation Mediated Suppression PCR Method for Simultaneous Bacteria DNA-Typing and Confirmation of Species: An Acinetobacter sp. Model
PublicationWe have designed a new ddLMS PCR (double digestion Ligation Mediated Suppression PCR) method based on restriction site polymorphism upstream from the specific target sequence for the simultaneous identification and differentiation of bacterial strains. The ddLMS PCR combines a simple PCR used for species or genus identification and the LM PCR strategy for strain differentiation. The bacterial identification is confirmed in the...
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The forecasts-based instrument rule and decision making. How closely interlinked? The case of Sweden
PublicationResearch background: The Central Bank of Sweden declared in years 1999–2006 the implementation of the Svensson’s concept of inflation forecast targeting (IFT). It means that the repo rate decision-making process depends on the inflation forecasts. The concept evolved from the strict IFT with the decision-making algorithm called ‘the rule of thumb’ to the flexible IFT. Purpose of the article: The aim of...
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New Approaches for Escherichia coli Genotyping
PublicationEasy-to-perform, fast, and inexpensive methods of differentiation of Escherichia coli strains beyond the species level are highly required. Herein two new, original tools for genotyping of E. coli isolates are proposed. The first of the developed method, a PCR-RFLP (polymerase chain reaction-restriction fragment length polymorphism) test uses a highly variable fliC gene, encoding the H antigen as a molecular target. The designing...
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Evolutionary Sets Of Safe Ship Trajectories: A New Approach To Collision Avoidance
PublicationThe paper introduces a new method of solving multi-ship encounter situations for both open waters and restricted water regions. The method, called evolutionary sets of safe trajectories combines some of the assumptions of game theory with evolutionary programming and aims to find optimal set of safe trajectories of all ships involved in an encounter situation. In a two-ship encounter situation it enables the operator of an on-board...
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Application of multicriteria decision analysis to assess the greenness of molecularly imprinted polymers synthesis components
PublicationThe study applies multicriteria decision analysis (MCDA) to rank the components of molecularly imprinted polymers (MIPs) synthesis according to their greenness. The components are taken from papers that are describing synthesis of MIPs for persistent organic pollutants (POPs) sorbents. Functional monomers (n = 14), target/surrogate molecules (n = 10), porogens (n = 8), cross-linking agents (n = 8) and initiators (n = 4) are described...
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A Fail-Safe NVRAM Based Mechanism for Efficient Creation and Recovery of Data Copies in Parallel MPI Applications
PublicationThe paper presents a fail-safe NVRAM based mechanism for creation and recovery of data copies during parallel MPI application runtime. Specifically, we target a cluster environment in which each node has an NVRAM installed in it. Our previously developed extension to the MPI I/O API can take advantage of NVRAM regions in order to provide an NVRAM based cache like mechanism to significantly speed up I/O operations and allow to preload...
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Low-energy positron scattering from DNA nucleobases: the effects from permanent dipoles
PublicationAb initio quantum calculations for low-energy positron scattering from gas-phase isolated molecular nucleobases which are part of the DNA structure are presented and discussed over the range of 1 eV to 25 eV. The calculations report the integral cross sections (ICSs) and the momentum-transfer cross sections (MTCSs) for Adenine, Guanine, Thymine and Cytosine. The calculations show very clearly the important role of the dominant...
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E-experiments in physics. Proper business process management, collaborative development process and project management guidance – remedy for avoiding the main IT project’s failure
PublicationOnly a few of learning aids and simulations of physical phenomena allow for building interactive experiments; experiments similar to those that should be conducted in physics laboratories at schools. Group of staff from Gdansk University of Technology decided to fill this market niche by designing and constructing a set of virtual experiments – so called e-experiments. To avoid common problems that a lot of IT products brought...
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Pesticide residues levels in honey from apiaries located of Northern Poland
PublicationConcentration levels of 30 pesticide residues were measured in honey samples collected from apiaries in northern part of Poland (Pomerania) using method based on the QuEChERS extraction followed by liquid chromatography-tandem mass spectrometry with electron spray ionization (LC-ESI-MS/MS). In 29% of the samples were found positive for at least some of the target compounds. Concentration of bifenthrin, fenpyroximate, methidathion,...
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Influence of plasmon resonance on the luminescence of titanium dioxide thin films doped with rare earth ions
PublicationIn this work the study of the optical properties of europium doped titanium dioxide thin films (TiO2:Eu) enhanced by gold plasmonic nanostructures are presented. Plasmonic platforms were manufactured by thermal annealing of thin film of Au, deposited on a Corning glass substrate. As a result of thermal treatment, gold spherical nanostructures with average dimensions of 50 nm were obtained. Luminescent TiO2:Eu film was deposited...
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Identification of continuous systems - Practical issues of insensitivity to perturbations
PublicationIn this paper the issue of continuous systems estimation, insensitive to certain perturbations, is discussed. Such an approach has rational advantages, especially when robust schemes are used to assist a target system responsible for industrial diagnostics. This requires that estimated model parameters are generated on-line, and their values are reliable and to a great extent accurate. Practical hints are suggested to challenge...
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Identification of Continuous Systems - Practical Issues of Insensitivity to Perturbations
PublicationIn this paper the issue of continuous systems estimation, insensitive to certain perturbations, is discussed. Such an approach has rational advantages, especially when robust schemes are used to assist a target system responsible for industrial diagnostics. This requires that estimated model parameters are generated on-line, and their values are reliable and to a great extent accurate. Practical hints are suggested to challenge...
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Dynamic Signal Strength Mapping and Analysis by Means of Mobile Geographic Information System
PublicationBluetooth beacons are becoming increasingly popular for various applications such as marketing or indoor navigation. However, designing a proper beacon installation requires knowledge of the possible sources of interference in the target environment. While theoretically beacon signal strength should decay linearly with log distance, on-site measurements usually reveal that noise from objects such as Wi-Fi networks operating in...
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Approximate Cramér–Rao bound on Doppler error in correlation-processing relatively narrowband noise radar
PublicationThe paper studies limitations on accuracy of Doppler estimation in continuous-wave noise radar with correlation processing. Second order properties of output of the correlation receiver are evaluated and an approximate Cram´er-Rao bound on errors of Doppler measurement is derived. The accuracy of Doppler measurements is found to be affected by the following factors: power spectral density of noise signal, frequency response of the...
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Low energy inelastic electron scattering from carbon monoxide: I. excitation of the a3Π, a’3Σ+ and AΠ1 electronic states.
PublicationDifferential scattering cross sections for electron excitation of the three lowest excited electron states of carbon monoxide are obtained experimentally using low-energy electron energy-loss spectroscopy and theoretically using the R-matrix method. The incident electron energies range from near-threshold of 6.3 eV to 20 eV. Experimental scattering angles range from 20◦ to 120◦. The normalization of the experimental cross sections...
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Assessment of the factors influencing on the formation of energy-oriented modes of electric power consumption by water-drainage installations of the mines
PublicationPurpose. Performing the analysis to determine energy-efficient modes and assess the characteristics of the main indicators of electric power consumption by mine water-drainage installations based on the developed research mathematical model. Methods. To achieve the purpose set, a methodology is used to develop the multiple multifactor correlation-regression modeling with respect to the modes of electric power consumption by electrical...
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Construction of glucosamine-6-phosphate synthase with an internal hexahistydyl fragment
PublicationL-Glutamine: D-fructose-6-phosphate aminotransferase (EC 2.6.1.16), known also as glucosamine-6-phosphate (GlcN-6-P) syntase, catalyzes the first committed step in the amino sugar biosynthetic pathway in prokaryotic and eukaryotic organisms. The enzyme carries out a complex reaction involving ammonia transfer and sugar phosphate isomerization. GlcN-6-P syntase is an important point of metabolic control of amino sugar biosynthesis...
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Modelling of acoustic backscattering by southern Baltic herring
PublicationAssessment of Baltic herring abundance can be carried out using acoustic techniques. Analysis of the relationship between the Baltic herring individual target strength, TS, and the total fish length, L, important for the acoustic assessment, showed the relationship to be dependent on the location of the study area. This finding motivated a detailed analysis of the relationship for the herring occurring in the southern Baltic...
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Methodology of the Morphometry Study on Baltic Herring
PublicationAcoustic techniques are used in the estimation of the abundance of Baltic herring. Investigations of the relationship between the Baltic herring individual target strength TS and the total fish length L, significant in the acoustic assessment, demonstrated its de-pendence on the study area location. It motivated the detailed analysis of the relationship between herring from the southern Baltic ICES Subdivisions 24, 25, and 26,...
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Isolation of the GFA1 gene encoding glucosamine-6-phosphate synthase of Sporothrix schenckii and its expression in Saccharomyces cerevisiae
PublicationGlucosamine-6-phosphate synthase (GlcN-6-P synthase) is an essential enzyme involved in cell wall biogenesis that has been proposed as a strategic target for antifungal chemotherapy. Here we describe the cloning and functional characterization of Sporothrix schenckii GFA1 gene which was isolated from a genomic library of the fungus. The gene encodes a predicted protein of 708 amino acids that is homologous to GlcN-6-P synthases...
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Effect of strain level on the stiffness of cold recycled bituminous mixtures
PublicationCold recycling is a sustainable technology for the rehabilitation of bitumi-nous pavements. This study investigates the stiffness response of cement-bitumen treated materials (CBTM)manufactured with 80% reclaimed asphalt and treated with 2.0% Portland cement and 4.0% bitumen emulsion. Indirect tensile stiffness modulus tests were carried out to assess the strain dependence of stiffness at target horizontal deformation levels between...
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Wear estimation of current collector contact strips by analysis of a 3D scanning results
PublicationThe technical condition of current collector contact strips is very important when operational reliability of railway transportation is considered. The authors proposed a novel measurement system based on a 3D camera to register the shape and dimensions of the current collector contact strips surface. The system was installed above the railway track for tests in target ambient. During the trial operation a few dozen of contact...
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Environmental Fate of Two Psychiatric Drugs, Diazepam and Sertraline: Phototransformation and Investigation of their Photoproducts in Natural Waters
PublicationExperimental studies were conducted to investigate the photodegradation of diazepam and sertraline, two of the most frequently used psychiatric drugs, induced by xenon lamp irradiation, which overlap the sunlight spectra, and natural sunlight. Degradation kinetics was established indicating the occurrence of autocatalytic reactions. The application of liquid chromatography coupled to quadrupole time-of-flight mass spectrometry...
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The Ellenbogen's "Matter as Software" Concept for Quantum Computer Implementation: III. Selection of X@C60 Molecular Building Blocks (MBBs) for Tip-Based Nanofabrication (TBN) of Trapped Neutral Atom Quantum Computing Devices
PublicationThe selection of guest atoms X of X@C60 MBBs for TBN of trapped neutral atom quantum computing devices is reported. Assuming the all-optical quantum computing as a final target stage, the two criteria are most important: the charge q accumulated on the C60 host must be as low as possible, and the atom X must have one or more available excited states within the band falling into the low energy window of neutral C60 molecule electronic...
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A new assay based on terminal restriction fragment length polymorphism of homocitrate synthase gene fragments for Candida species identification
PublicationCandida sp. have been responsible for an increasing number of infections, especially in patients with immunodeficiency. Species specific differentiation of the Candida sp. is difficult in routine diagnosis. This identification can have a highly significant association in therapy and prophylaxis. This work has shown a new application of terminal restriction fragment length polymorphism (t-RFLP) method in molecular identification...
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Synthesis and biological evaluation of N-acylated tyramine sulfamates containing C-F bonds as steroid sulfatase inhibitors
PublicationSteroid sulfatase (STS) is responsible for the hydrolysis of biologically inactive sulfated steroids into their active un-sulfated forms and promotes the growth of various hormone-dependent cancers (e.g., breast cancer). Therefore, the STS enzyme is a promising therapeutic target for the treatment of steroid-sensitive cancers. Herein, we report the synthesis and biological evaluation of sulfamate analogs as potential STS inhibitors...
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Comparative Analysis of Two Polish Hyperbolic Systems AEGIR and JEMIOLUSZKA
PublicationGlobal Navigation Satellite System (GNSS) is seen by terrorists or hostile countries as a high value target. Volpe Center report contains the following statement: “During the course of its development for military use and more recent extension to many civilian uses, vulnerabilities of Global Navigation Satellite Systems (GNSS) – in the United States the Global Positioning System (GPS) – have become apparent. The vulnerabilities...
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Inhibitors of glucosamine-6-phosphate synthase as potential antimicrobials or antidiabetics – synthesis and properties
PublicationGlucosamine-6-phosphate synthase (GlcN-6-P synthase) is known as a promising target for antimicrobial agents and antidiabetics. Several compounds of natural or synthetic origin have been identified as inhibitors of this enzyme. This set comprises highly selective L-glutamine, amino sugar phosphate or transition state intermediate cis-enolamine analogues. Relatively low antimicrobial activity of these inhibitors, poorly penetrating...
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Evaluating Asymmetric N-Grams as Spell-Checking Mechanism
PublicationTypical approaches to string comparing marks two strings as either different or equal without taking into account any similarity measures. Being able to judge similarity is however required for spelling error corrections, as we want to find the best match for a given word. In this paper we present a bi2quadro-grams method for spelling errors correction. The method proposed uses different n-grams dimension for the source (checked)...
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The Role of a Software Product Manager in Various Business Environments
PublicationThe aim of the paper is to identify the role of the software product manager depending on the size of the company and the characteristics of the product they are working on. This has been achieved in cooperation with 15 experts from the IT industry. The companies were divided into 4 levels of size: micro-enterprises, small businesses, medium businesses and large enterprises. The characteristics of the products were divided into...
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Towards Synthetic and Balanced Digital Government Benchmarking
PublicationReliable benchmarking is essential for effective management of the government digitalization efforts. Existing benchmarking instruments generally fail to support this target. One problem is the diversity of instruments, resulting in a split image of digital progress and adding ambiguity to policy decisions. Another problem is disconnect in assessing progress between digital and traditional “analog” governance, lending support to...
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Dynamic tests of composite footbridge segment – experimental and numerical studies
PublicationExperimental dynamic tests and numerical simulations of a 3 meters long segment of a footbridge made of polymer composites are presented in the paper. The span-length is reduced, however dimensions of cross-section are the same as the target footbridge. The segment structure is made of sandwich panels, which consist of fibre reinforced polymer (GFRP) laminates (skins) and a PET foam (core). The first part of the paper contains...
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Recent progress in the development of steroid sulfatase inhibitors – examples of the novel and most promising compounds from the last decade
PublicationThe purpose of this review article is to provide an overview of recent achievements in the synthesis of novel steroid sulfatase (STS) inhibitors. STS is a crucial enzyme in the biosynthesis of active hormones (including estrogens and androgens) and, therefore, represents an extremely attractive molecular target for the development of hormone-dependent cancer therapies. The inhibition of STS may effectively reduce the availability...
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Is sequential batch reactor an efficient technology to protect recipient against non-steroidal anti-inflammatory drugs and paracetamol in treated wastewater?
PublicationThe tested facility was a wastewater treatment plant (WWTP) in Swarzewo, where the wastewater treatment takes place in aeration chambers with activated sludge using sequential batch reactors (SBRs). The concentration of the following pharmaceuticals: ibuprofen, paracetamol, flurbiprofen, naproxen, diclofenac, and its metabolites 5OH-diclofenac and 4OH-diclofenac was tested in influents and effluents. Simultaneously, the conventional...
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Survey of Methodologies, Approaches, and Challenges in Parallel Programming Using High-Performance Computing Systems
PublicationThis paper provides a review of contemporary methodologies and APIs for parallel programming, with representative technologies selected in terms of target system type (shared memory, distributed, and hybrid), communication patterns (one-sided and two-sided), and programming abstraction level. We analyze representatives in terms of many aspects including programming model, languages, supported platforms, license, optimization goals,...
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Low-Cost and Precise Automated Re-Design of Antenna Structures Using Interleaved Geometry Scaling and Gradient-Based Optimization
PublicationDesign of contemporary antennas is an intricate endeavor involving multiple stages, among others, tuning of geometry parameters. In particular, re-designing antennas to different operating frequencies, makes parametric optimization imperative to ensure the best achievable system performance. If the center frequency at the current design is distant from the target one, local tuning methods generally fail, whereas global algorithms...
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Extension management of a knowledge base migration process to IPv6
PublicationThere are many reasons to deploy IPv6 protocol with IPv4 address space depletion being the most indisputable. Unfortunately, migration to IPv6 protocol seems slower than anticipated. To improve pace of the IPv6 deployment, authors of the article developed the two applications that supports the migration process. Their main purpose is to help less experienced network administrators facilitate the migration process with a particular...
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Isoprostanes-Biomarkers of Lipid Peroxidation: Their Utility in Evaluating Oxidative Stress and Analysis
PublicationIsoprostanes (IsoPs) are key biomarkers for investigating the role of free radical generation in the pathogenesis of human disorders. To solve IsoPs-related problems with regard to isoprostanes, analytical tools are required. This paper reviews the problems and trends in this field focusing on the methodology for assaying biomarkers in exhaled breath condensate (EBC) samples. A large amount of work has been done in the qualitative...
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Sésame, ouvre-toi: internationalisme phraséologique à contenu universel
PublicationPhraseological units, characterised by their opaque meaning, are the subject of multiple theoretical works. The following article adds to this discussion by providing another interesting example. It analyses the case of the Arabic phraseological unit ‘open sesame’ from the “Ali Baba and the Forty Thievesˮ folk tale, permeating into French, Italian, Polish, Turkish and Japanese – languages distant both linguistically and culturally....
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Mechatronic design o strongly nonlinear systems on a basis of three wheeled mobile platform
PublicationRemarkable grow in demand both of mobile platform operability performance and reduction of project leading time development encourage to apply modern algorithms and reliable engineering tools for the design process. The paper discusses the mechatronic design applied for the surveillance system based on the energy performance index algorithm. The exploited mechatronic techniques i.e. virtual prototyping, Hardware-In-the-Loop Simulation...
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Nanocrystallization as a tool for controlling in vitro dissolution of borophosphate glass
PublicationThe controlled nanocrystallization of sodium-calcium-borophosphate glass (Na16.6Ca5.1B10.5Al0.8P10.5 O56.5 in at %) was conducted to investigate its influence on in vitro dissolution. Three temperatures (570 ◦C, 590 ◦C, and 610 ◦C) were selected based on thermal analysis and investigation of the morphology, structure, and in vitro dissolution of glass and glass-ceramics was conducted. The results of X-ray diffraction confirmed...
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Antimicrobial molecular nanocarrier–drug conjugates
PublicationMany antimicrobial drugs are poorly active against pathogenic microbes causing intracellular infections, such as Mycobacterium tuberculosis or Plasmodium falciparum. On the other hand, several known antimicrobial agents are not effective enough because of their limited cellular penetration. A common feature of both challenges is the inability of an active agent to cross the biological membrane(s). One of the possible approaches...
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A Model-Driven Solution for Development of Multimedia Stream Processing Applications
PublicationThis paper presents results of action research related to model-driven solutions in the area of multimedia stream processing. The practical problem to be solved was the need to support application developers who make their multimedia stream processing applications in a supercomputer environment. The solution consists of a domain-specific visual language for composing complex services from simple services called Multimedia Stream...
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Biofilm formation and its regulation in Staphylococcus aureus
PublicationInfections caused by the major human and animal pathogen, Staphylococcus aureus are becoming an important problem due to its emerging resistance mechanisms and variety of virulence factors. Biofilm formation is considered to be one of the most important factor attributed to high pathogenicity of S. aureus. Described in the literature methods used in identification of biofilm forming abilities of bacteria consist of phenotypic and...
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The innovative exploitation of Brassica vegetables in the health quality food production chain
PublicationIn this overview the multidirectional opportunities of innovative exploitation of chemical and biological properties of vegetables from Brassiceae family are discussed. The specific chemical composition of brassicas, as regard both nutrients and non-nutrients, renders them particularly suitable for the health food production chain, literally from field to fork. the ability of these plants to accumulate heavy metals may be utilised...
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The innovative Exploitation of Brassica Vegetables in the Health Quality Food Production Chain
PublicationIn this overview the multidirectional opportunities of innovative exploitation of chemical and biological properties of vegetables from Brassiceae family are discussed. The specific chemical composition of brassicas, as regard both nutrients and non-nutrients, renders them particularly suitable for the health food production chain, literally from field to fork. the ability of these plants to accumulate heavy metals may be utilised...
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Pesticides in the Environment
PublicationApplied all over the world, pesticides are some of the most dangerous pollutants of the environment becauseof their mobility and ability to accumulate in the environment and their consequent long-term adverseeffects on living organisms in general and human health in particular. For these reasons, it is essential tomonitor and analyze pesticide residues in the environment. This entry discusses the classification of pesticidesas...