Search results for: DU%C5%BBE%20MOCE%20MIKROFALOWE

• 5-Thiocyanato-2′-deoxyuridine as a possible radiosensitizer: electron-induced formation of uracil-C5-thiyl radical and its dimerization

  Publication

  • M. Zdrowowicz
  • L. Chomicz
  • M. Żyndul
  • P. Wityk
  • J. Rak
  • T. Wiegand
  • C. Hanson
  • A. Adhikary
  • M. Sevilla

  - PHYSICAL CHEMISTRY CHEMICAL PHYSICS - Year 2015

  In this work, we have synthesized 5-thiocyanato-2′-deoxyuridine (SCNdU) along with the C6-deuterated nucleobase 5-thiocyanatouracil (6-D-SCNU) and studied their reactions with radiation-produced electrons. ESR spectra in γ-irradiated nitrogen-saturated frozen homogeneous solutions (7.5 M LiCl in H2O or D2O) of these compounds show that electron-induced S–CN bond cleavage occurs to form a thiyl radical (dU-5-S˙ or 6-D-U-5-S˙) and...

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• 5-Selenocyanato and 5-trifluoromethanesulfonyl derivatives of 2′-deoxyuridine: synthesis, radiation and computational chemistry as well as cytotoxicity

  Publication

  • S. Makurat
  • M. Zdrowowicz
  • L. Chomicz-Mańka
  • W. Kozak
  • I. E. Serdiuk
  • P. Wityk
  • A. Kawecka
  • M. Sosnowska
  • J. Rak

  - RSC Advances - Year 2018

  5-Selenocyanato-2′-deoxyuridine (SeCNdU) and 5-trifluoromethanesulfonyl-2′-deoxyuridine (OTfdU) have been synthesized and their structures have been confirmed with NMR and MS methods. Both compounds undergo dissociative electron attachment (DEA) when irradiated with X-rays in an aqueous solution containing a hydroxyl radical scavenger. The DEA yield of SeCNdU significantly exceeds that of 5-bromo-2′-deoxyuridine (BrdU), remaining...

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