Search results for: PILI AND FIMBRIAE

• Pilicides effectively hinder chaperone-usher interactions in all Gram-negative bacteria

  Publication

  • J. Pilipczuk
  • B. Zalewska-Piątek
  • K. Dzierzbicka
  • S. Makowiec
  • R. Piątek
  • A. Cyrancka-Czaja

  - Year 2012

  The chaperone-usher pathway of adhesive structures biogenesis is highly conserved in all Gram-negative bacteria. Pili are polymers of thousands protein subunits that possess conserved immunoglobuline-like structure denoted by lack of the seventh G strand. The effect of this structural defect is a hydrophobic acceptor cleft. The folding of protein subunits is strictly dependent on the action of specific periplasmic chaperone protein...

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• A shear stress micromodel of urinary tract infection by the Escherichia coli producing Dr adhesin

  Publication

  • B. Zalewska-Piątek
  • M. Olszewski
  • T. Lipniacki
  • S. Błoński
  • M. Wieczór
  • P. Bruździak
  • A. Skwarska
  • B. Nowicki
  • S. Nowicki
  • R. Piątek

  - PLoS Pathogens - Year 2020

  In this study, we established a dynamic micromodel of urinary tract infection to analyze the impact of UT-segment-specific urinary outflow on the persistence of E. coli colonization. We found that the adherence of Dr+ E. coli to bladder T24 transitional cells and type IV collagen is maximal at lowest shear stress and is reduced by any increase in flow velocity. The analyzed adherence was effective in the whole spectrum of physiological...

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