Search results for: SHEAR STRESSS

• A shear stress micromodel of urinary tract infection by the Escherichia coli producing Dr adhesin

  Publication

  • B. Zalewska-Piątek
  • M. Olszewski
  • T. Lipniacki
  • S. Błoński
  • M. Wieczór
  • P. Bruździak
  • A. Skwarska
  • B. Nowicki
  • S. Nowicki
  • R. Piątek

  - PLoS Pathogens - Year 2020

  In this study, we established a dynamic micromodel of urinary tract infection to analyze the impact of UT-segment-specific urinary outflow on the persistence of E. coli colonization. We found that the adherence of Dr+ E. coli to bladder T24 transitional cells and type IV collagen is maximal at lowest shear stress and is reduced by any increase in flow velocity. The analyzed adherence was effective in the whole spectrum of physiological...

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