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Search results for: atp synthase
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Wave energy attenuation in fields of colliding ice floes – Part 2: A laboratory case study
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Synthesen, Strukturen und Reaktionsverhalten von Metallalkoxiden
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Sporothrix schenckii: purification and partial biochemical characterisation of glucosamine-6-phosphate synthase, a potential antifungal target
PublicationW artykule opisano izolację i charakterystykę właściwości natywnego enzymu, syntazy GlcN-6-P z komórek dimorficznego grzyba patogennego Sporothrix schenckii. Masę cząsteczkową enzymu natywnego określono na 350 kDa, a enzymu zdenaturowanego na około 79 kDa, co sugeruje homotetrameryczną strukturę białka. Wartość punktu izoelektrycznego wyniosła 6,26; wyznaczono także parametry kinetyczne katalizowanej reakcji. Aktywność enzymu była...
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Development of Biocompatible Fe3O4@SiO2 Nanoparticles as Subcellular Delivery Platform for Glucosamine-6-phosphate Synthase Inhibitors
PublicationNumerous inhibitors of glucoseamine-6-phophate synthase (GlcN-6-P), the enzyme responsible from catalysis of the first step of metabolic pathway leading to metabolism 5’-diphospho-N-acetyl-D- glucosamine, were reported as effective agents for inhibiting the growth of various fungal pathogens. Among the reported inhibitors,...
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Synthesis of Trehalose by the Erythritol-Producing Yeast Yarrowia lipolytica Co-Displaying Maltooligosyltrehalose Synthase and Maltooligosyltrehalose Trehalohydrolase
PublicationIndustrial trehalose production faces economic challenges with costly enzyme preparations, prompting the exploration of eco-friendly alternatives. Here, we established a coupled functional sugar production line leveraging erythritolproducing cells as an innovative enzyme preparation for trehalose synthesis. The erythritol-producing Yarrowia lipolytica was modified to express a fusion protein consisting of maltooligosyltrehalose synthase...
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Emerging anticancer activity of candidal glucoseamine-6-phosphate synthase inhibitors upon nanoparticle-mediated delivery
PublicationNumerous glutamine analogues have been reported as irreversible inhibitors of the glucosamine-6-phosphate (GlcN-6-P) synthase in pathogenic Candida albicans in the last 3.5 decades. Among the reported inhibitors, the most effective N3-(4-methoxyfumaroyl)-L-2,3- diaminopropanoic acid (FMDP) has been extensively studied in order to develop its more active analogues. Several peptide−FMDP conjugates were tested to deliver FMDP to its...
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Wave-induced stress and breaking of sea ice in a coupled hydrodynamic–discrete-element wave–ice model
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Wave-induced stress and breaking of sea ice in a coupled hydrodynamic–discrete-element wave–ice model
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Wave-induced stress and breaking of sea ice in a coupled hydrodynamic–discrete-element wave–ice model
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Use of the AHP Method for Preference Determination in Yacht Design
PublicationA sailing yacht is a human-centred product, the design of which revolves primarily around the wants and desires of the future owner. In most cases, these preferences are not measurable, such as a personal aesthetic feeling, or a need for comfort, speed, safety etc. The aims of this paper are to demonstrate that these preferences can be classified and represented numerically, and to show that they are correlated with the type...
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Analysis of transformer state by fuzzy TOPSIS and AHP method
PublicationThe paper presents mathematical models TOPSIS and AHP methods, which was utilized on insulating state of distribution transformer to analyze and sensibility of individual measurements methods mutual comparison. We can uniquely determine the importance of these measurements methods with this mathematical apparatus in these measurements methods in insulating state of transformers.
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Application of membrane distillation process for tap water purification
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Use of the AHP Method for Preference Determination in Yacht Design
PublicationA sailing yacht is a human-centred product, the design of which revolves primarily around the wants and desires of the future owner. In most cases, these preferences are not measurable, such as a personal aesthetic feeling, or a need for comfort, speed, safety etc. The aims of this paper are to demonstrate that these preferences can be classified and represented numerically, and to show that they are correlated with the type of...
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Quasi-controlled Experimentations on the Impact of AOP on Software Comprehensibility
PublicationAspect-oriented programming (AOP) emerged as a paradigm to modularize the concerns that lead to interwoven code if implemented using traditional programming techniques. Unfortunately, the new constructs introduced by aspect-oriented (AO) languages result in both: (1) obstacles in modular reasoning, and (2) high coupling between aspects and the augmented modules. There have been numerous attempts to tackle these issues, but none...
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Correction to “Emerging Anticancer Activity of Candidal Glucosamine-6-Phosphate Synthase Inhibitors upon Nanoparticle-Mediated Delivery”
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Molecular modelling of transition state analogue inhibitors of glucosamine-6-P synthase and glucose-6-P isomerase.
PublicationStruktura kompleksu 2-amino-2-deoksy-D-glucitolo-6-P (ADGP) z centrum aktywnym syntazy GlcN-6-P z E. coli została wykorzystAna jako punkt wyjścia do modelowania molekularnego analogów ADGP. Używając programu GROMOS96 wygenerowano konformacje analogów o najniższych energiach wewnętrznych, które następnie ''dokowano'' w centrum aktywnym enzymu. Dokonano syntezy wybranych związków i określono parametry kinetyczne i termodynamiczne...
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Isolation of the GFA1 gene encoding glucosamine-6-phosphate synthase of Sporothrix schenckii and its expression in Saccharomyces cerevisiae
PublicationGlucosamine-6-phosphate synthase (GlcN-6-P synthase) is an essential enzyme involved in cell wall biogenesis that has been proposed as a strategic target for antifungal chemotherapy. Here we describe the cloning and functional characterization of Sporothrix schenckii GFA1 gene which was isolated from a genomic library of the fungus. The gene encodes a predicted protein of 708 amino acids that is homologous to GlcN-6-P synthases...
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Crystallization and preliminary X-ray analysis of the isomerase domain of glucosamine-6-phosphate synthase from Candida albicans
PublicationSyntaza glukozamino-6-fosforanu (EC 2.6.1.16) katalizuje pierwszy, praktycznie nieodwracalny etap w szlaku biosyntezy heksozoamin, którego produktem końcowym jest UDP-GlcNAc, kluczowy substrat dla tworzenia ściany komórkowej drobnoustrojów. Otrzymano kryształy domeny izomerazowej syntazy GlcN-6-P z Candida albicans, składającej się z reszt 346-712 (42 kDa). Analiza rentgenograficzna kryształu wykazała, że należy on do grupy przestrzennej...
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Long range molecular dynamics study of regulation of eukaryotic glucosamine-6-phosphate synthase activity by UDP-GlcNAc
PublicationGlucosamine-6-phosphate (GlcN-6-P) synthase catalyses the first and practically irreversible step in hexosamine metabolism. The final product of this pathway, uridine 5' diphospho N-acetyl-D-glucosamine (UDPGlcNAc), is an essential substrate for assembly of bacterialand fungal cell walls. Moreover, the enzyme is involved in phenomenon of hexosamine induced insulin resistance in type II diabetes, which makes it a potential target...
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Organic syntheses greenness assessment with multicriteria decision analysis
PublicationGreen chemistry requires a metrics system that is comprehensive by the criteria included and simple in the application at the same time. We propose the application of multicriteria decision analysis for com- parative greenness assessment of organic synthesis procedures. The assessment is based on 9 criteria (the reagent, reaction efficiency, atom economy, temperature, pressure, synthesis time, solvent, catalyst and reactant) for...
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Mechanochemical Energy Transduction during the Main Rotary Step in the Synthesis Cycle of F1-ATPase
PublicationF1-ATPase is a highly efficient molecular motor that can synthesize ATP driven by a mechanical torque. Its ability to function reversibly in either direction requires tight mechanochemical coupling between the catalytic domain and the rotating central shaft, as well as temporal control of substrate binding and product release. Despite great efforts and significant progress, the molecular details of this synchronized and fine-tuned...
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HYPONATREMIA & WATER INTOXICATION WITH CARBAMAZEPINE: A RARE CASE REPORT.
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HYPONATREMIA & WATER INTOXICATION WITH CARBAMAZEPINE: A RARE CASE REPORT.
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An English afternoon tea at Fortnum & Mason's: scenariusz lekcji
PublicationNiniejszy scenariusz lekcji prezentuje jedną z flagowych tradycji Wielkiej Brytanii – afternoon tea, znaną w języku polskim jako popołudniowa herbatka lub, bardziej poprawnie, podwieczorek. Uczeń wirtualnie wyrusza do londyńskiej herbaciarni Fortnum & Mason, gdzie poznaje słownictwo dotyczące rezerwacji stolika oraz uczy się, jak zamówić podwieczorek. Ponadto...
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Inconsistent i contradictory judgements in pairwise comparison method in AHP.
PublicationCelem artykułu jest pokazanie zależności pomiędzy niezgodnymi i sprzecznymi macierzami danych, otrzymywanymi w wyniku porównań parami niewielkiej, skończonej libzy wariantów decyzyjnych. W szczególności pokazuje się macierze, które mimo prawidłowego wyniku testu zgodności posiadają oceny sprzeczne. Przedstawia się algorytm sprawdzający zgodność ocen.
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Problem of inconsistent and contradictory judgements in pairwise comparisonmethod in sense of AHP
PublicationThe aim of this paper is to show the relationship between inconsistent and contradictory matrices of data obtained as a result of the pairwise comparison of factors in the sense of the Analytic Hierarchy Process. The consistency check is performed to ensure that judgements are neither random nor illogical. This paper shows that even if a matrix will pass a consistency test successfully, it can be contradictory. Moreover an algorithm...
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The Selection of Anchoring System for Floating Houses by Means of AHP Method
PublicationThis paper indicates and analyses the use of anchoring systems, such as mooring piles, booms, mooring cables, and deadweight anchors with additional elastic connectors, which are the most frequently applied by the producers of floating houses. The selection of the most advantageous anchoring system is complicated and requires the application of quantitative and qualitative data and methods. This publication presents the results...
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Construction, purification, and functional characterization of His-tagged Candida albicans glucosamine-6-phosphate synthase expressed in Escherichia coli
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A new assay based on terminal restriction fragment length polymorphism of homocitrate synthase gene fragments for Candida species identification
PublicationCandida sp. have been responsible for an increasing number of infections, especially in patients with immunodeficiency. Species specific differentiation of the Candida sp. is difficult in routine diagnosis. This identification can have a highly significant association in therapy and prophylaxis. This work has shown a new application of terminal restriction fragment length polymorphism (t-RFLP) method in molecular identification...
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Conductivity and superconductivity of (Bi,Pb)4Sr3Ca3Cu4Ox glass-ceramics.
PublicationW układzie(Bi,Pb)-Sr-Ca-Cu-O poprzez krystalizację w fazie stałej można wytworzyć materiały o bardzo różnych właściwościach elektrycznych i nadprzewodzących. W zależności od warunków krystalizacji, można wytworzyć nadprzewodnik o temperaturze krytycznej między 8 a 105 st.K lub materiał nie przechodzący do stanu nadprzewodzącego. W pracy pokazano i przedyskutowano wpływ składu fazowego, struktury i mikrostruktury na przewodnictwo...
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Cationic porphyrazines with morpholinoethyl substituents – Syntheses, optical properties, and photocytotoxicities
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Porphyrazines as Molecular Scaffolds: Flexible Syntheses of Novel Multimetallic Complexes
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Syntheses and DNA binding of new cationic porphyrin–tetrapeptide conjugates
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Syntheses and structures of the first terminal phosphanylphosphido complexes of molybdenum(IV)
PublicationThe reactions of R2P-P(SiMe3)Li (R = tBu, iPr2N) with [Cp2MoCl2] yield terminal phosphanylphosphido complexes formally via the insertion of the phosphinidene P-atom into the C - H bond of a cyclopentadienyl ring and the migration of the hydrogen atom or SiMe3 moiety to the molybdenum centre. Solid state structures of [Cp(C5H4P-PtBu2)MoH], [Cp(C5H4P-PtBu2)Mo(SiMe3)] and [Cp{C5H4P-P(NiPr2)2}Mo(SiMe3)] were established by single crystal...
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Syntheses and Structures of Transition Metal Complexes with Phosphanylphosphinidene Chalcogenide Ligands
PublicationThe reactivity of the phosphanylphosphinidene complex [(DippN)2W(Cl)(η2-P-PtBu2)]− (1) toward chalcogens (Ch = Se, S) was studied. Reactions of stoichiometric amounts of 1 with chalcogens in DME yielded monomeric tungsten complexes with phosphanylphosphinidene chalcogenide ligands of the formula tBu2P−P−Ch (Ch = Se (in 2) and S (in 5)), which can be regarded as products of the addition of a chalcogen atom to a P=W bond in starting...
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Wave energy attenuation in fields of colliding ice floes – Part 1: Discrete-element modelling of dissipation due to ice–water drag
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Single nucleotide polymorphisms in A4GALT spur extra products of the human Gb3/CD77 synthase and underlie the P1PK blood group system
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Long range molecular dynamics study of interactions of the eukaryotic glucosamine-6-phosphate synthase with fructose-6-phosphate and UDP-GlcNAc
PublicationGlucosamine-6-phosphate synthase (EC 2.6.1.16) is responsible for catalysis of the first and practically irreversible step in hexosamine metabolism. The final product of this pathway, uridine 5 diphospho Nacetyl- d-glucosamine (UDP-GlcNAc), is an essential substrate for assembly of bacterial and fungal cell walls. Moreover, the enzyme is involved in phenomenon of hexosamine induced insulin resistance in type II diabetes, which...
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The Impact of the Quality of Tap Water and the Properties of Installation Materials on the Formation of Biofilms
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Beneficial effect of ovocystatin on the cognitive decline in APP/PS1 transgenic mice
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Self-healing ATM networks based on preplanned restoration of virtual paths
PublicationW pracy omówiono klasyfikację metod odtwarzania usług w samonaprawialnych sieciach ATM opartych na ścieżkach wirtualnych i o topologii kratkowej. Przedstawiono model z zaplanowanymi z góry ścieżkami zabezpieczającymi i wyniki badań przykładowej sieci w Polsce.
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Zastosowanie metody AHP do oceny zagrożeń na stanowiskach pracy.
PublicationW artykule przedstawiono podstawy wielokryterialnej metody wspomagania decyzji AHP (ang. Analytic Hierarchy Process) oraz jej zastosowanie do oceny zagrożeń na stanowiskach pracy.
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PORÓWNANIE PROJEKTÓW BUDOWY FARM WIATROWYCH Z WYKORZYSTANIEM METODY AHP
PublicationW referacie opisano porównanie projektów budowy farm wiatrowych będących w różnych stadiach realizacji przygotowania inwestycji. Metodą, którą wykorzystano do porównania projektów jest metodą analizy wielokryterialnej AHP (Analytic Hierarchy Process). Referat przedstawia opis metody oraz kryteriów, pod względem których porównano projekty. Wykazano, że dla projektu P2 czas zdobycia wszystkich niezbędnych...
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PROBLEM RUCHU SMS A2P - JEGO ANALIZA I SPOSOBY ROZWIĄZANIA
PublicationRuch SMSowy typu A2P (Application to Person) jest dla operatorów źródłem problemów, które objawiają się dla jednych w postaci strat, a dla innych nieuprawnionymi zyskami. W artykule omówiono ten problem od strony technicznej, tzn. gdzie leży jego przyczyna i jak można przeciwdziałać temu zjawisku i mieć jednocześnie z tego tytułu korzyści.
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Synthesis, anticandidal activity of N3-(4-methoxyfumaroyl)-(S)-2,3-diaminopropanoic amide derivatives – Novel inhibitors of glucosamine-6-phosphate synthase
PublicationNovel FMDP amiders 4-6 have been synthesized and tested against Candida strains. The anticandidal activity has been confined only to Candida albicans. Anticandidal activity of the tested amides has correlated with their inhibitory activity of glucosamine-6-phosphate synthase in cell free extract from Candida albicans.
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Modification of quaternary structure of Candida albicans GlcN-6-P synthase and its desensitization to inhibition by UDP-GlcNAc by site-directed mutagenesis
PublicationSite-directed mutagenesis of the CaGFA1 gene encoding glucosamine-6-phosphate synthase from Candida albicans was performed. Desensitization of the enzyme to inhibition by UDPGlcNAc was achieved upon T487I and H492F substitutions at the UDP-GlcNAc binding site, exchange of D524, S525 and S527 for Ala at the dimer:dimer interface and construction of the tail-lock array (L434R and L460A) at the C-tail region. The first two sets if...
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Development of biocompatible iron oxide-silicon oxide core-shell nanoparticles as subcellular delivery platform for glucosamine-6-phosphate synthase inhibitors
PublicationIn order to develop the preparation of iron oxide-silica coreshell nanoparticles (CSNPs), thesis deeply explores the cetyltrimethylammonium (CTA+) directed silica coating methods of the oleic-acid capped iron oxide nanoparticles (OA-IONPs) initialized under near-neutral pH conditions. It is demonstrated that the initial alkaline hydrolysis of ethyl acetate in the presence of CTA+ and OA-IONPs induces an unusual ligand exchange...
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Mechanism of Biofilm Formation on Installation Materials and Its Impact on the Quality of Tap Water
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SELF-ENUCLEATION OF BOTH EYES IN SCHIZOPHRENIA & INTELLECTUAL DISABILITY: A CURSE OR A BLESSING?
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SELF-ENUCLEATION OF BOTH EYES IN SCHIZOPHRENIA & INTELLECTUAL DISABILITY: A CURSE OR A BLESSING?
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