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Search results for: DRAD PROTEIN
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Modification of quaternary structure of Candida albicans GlcN-6-P synthase and its desensitization to inhibition by UDP-GlcNAc by site-directed mutagenesis
PublicationSite-directed mutagenesis of the CaGFA1 gene encoding glucosamine-6-phosphate synthase from Candida albicans was performed. Desensitization of the enzyme to inhibition by UDPGlcNAc was achieved upon T487I and H492F substitutions at the UDP-GlcNAc binding site, exchange of D524, S525 and S527 for Ala at the dimer:dimer interface and construction of the tail-lock array (L434R and L460A) at the C-tail region. The first two sets if...
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Insight into the oligomeric structure of PORA from A. thaliana
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Process control of leakages in refinery reforming plant by means of Normal Phase High Performance Liquid Chromatography (HPLC)
PublicationPraca dotyczy zbadania możliwości, opracowania nowej procedury badawczej oraz dokonania oznaczeń ¬m-krezolu w strumieniu produktu z procesu reformingu katalitycznego techniką wysokosprawnej chromatografii cieczowej w układzie faz normalnych, z detektorem spektrofotometrycznym typu DAD (NP-HPLC-UV-VIS/DAD). Opracowana procedura stanowi alternatywę dla innych procedur wykorzystujących klasyczne techniki analityczne, albo wykorzystanie...
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MRM–MS of marker peptides and their abundance as a tool for authentication of meat species and meat cuts in single-cut meat products
PublicationThe abundance of protein markers in different types of meat cuts was explored in the context of authentication of raw meat (pork, beef and chicken) and processed meat products. Peptides originating from myoglobin (Mb) and myosin (My) were analyzed using multiple reaction monitoring mass spectrometry (MRM–MS). Analytical protocol was optimized for good repeatability (CV < 10%) and high sensitivity. The MS signal intensity of Mb...
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Influence of mussels (Mytilus galloprovincials) from polluted and non-polluted areas on some atherosclerosis indices in rats fed cholesterol
PublicationBadano wpływ diety z dodatkiem małży z obszarów zanieczyszczonych i obszarów czystych ekologicznie na niektóre objawy arteriosklerozy u szczurów.Na podstawie wyników badań in vitro, małże pochodzące z obszarów zanieczyszczonych charakteryzują sie większą zawartością protein, metali ciężkich oraz przeciwutleniaczy.Badania przeprowadzono na 28 szczurach podzielonych na 4 grupy. Szczury z grupy kontrolnej otrzymywały podstawową diete...
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Białka prokariotycznego systemu MMR: rola oraz interakcje
PublicationUszkodzenia komórkowego DNA w postaci błędnie sparowanych lub niesparowanych zasad azotowych są wynikiem niewłaściwie zachodzących procesów metabolizmu DNA, takich jak replikacja, rekombinacja oraz naprawa DNA. Utrwalenie tego rodzaju zmian prowadzi do powstania mutacji. System MMR (ang. DNA mismatch repair) usuwa te uszkodzenia przyczyniając się do zwiększenia wierności replikacji DNA oraz utrzymania stabilności genomu komórki....
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Sodium alginate decreases the permeability of intestinal mucus
PublicationIn the small intestine the nature of the environment leads to a highly heterogeneous mucus layer primarily composed of the MUC2 mucin. We set out to investigate whether the soluble dietary fibre sodium alginate could alter the permeability of the mucus layer. The alginate was shown to freely diffuse into the mucus and to have minimal effect on the bulk rheology when added at concentrations below 0.1%. Despite this lack of interaction...
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Electronic noses: Powerful tools in meat quality assessment
PublicationMain factors that are considered by consumers when choosing meat products are colour and aroma, of which the latter is a more reliable indicator of quality. However, a simple sensory evaluation of hedonistic qualities is often not sufficient to determine whether protein is past its shelf life, and consumption of spoiled meat can lead to serious health hazards. Some volatile compounds can be used as spoilage indicators, and so a...
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Isolation of Citrus lemon extracellular vesicles: Development and process control using capillary electrophoresis
PublicationA new and scalable method for the isolation of extracellular vesicles (EV) from Citrus lemon juice samples was developed. The methodology included preliminary preconcentration of the sample using ultrafiltration (UF) followed by size-exclusion chromatography (SEC) purification and final preconcentration of the eluates. Transmission electron microscopy and proteomic analysis showed that isolates contained exosome-like vesicles, exocyst-positive...
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Analytical Strategies and Applications in Lipidomics
PublicationLipidomics is a field of study aiming at a comprehensive analysis of a set of lipids in biological systems. This includes both quantitative and qualitative characterization of lipid profiles, comparative studies of lipidomes, and analysis of lipid-protein interactions. Lipids are structurally diversified that make their analysis a challenging task. The constant advances in analytical technologies, especially in the field of high-performance...
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Amino Acid and Peptide‐Based Antiviral Agents
PublicationA significant number of antiviral agents used in clinical practice are amino acids, short peptides, or peptidomimetics. Among them, several HIV protease inhibitors (e. g. lopinavir, atazanavir), HCV protease inhibitors (e. g. grazoprevir, glecaprevir), and HCV NS5A protein inhibitors have contributed to a significant decrease in mortality from AIDS and hepatitis. However, there is an ongoing need for the discovery of new antiviral...
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Water uptake and energetics of the formation of barium zirconate based multicomponent oxides
PublicationA group of multi-component oxides based on BaZrO3 have been prepared using a solid-state reaction method and examined in terms of their water uptake and thermodynamics of formation. Depending on the type and amount of acceptor substitution, the synthesized compounds exhibit various proton defect concentrations, reaching up to 0.2 mol/mol for a compound containing 10 different elements in the B-sublattice, where 50% of them are...
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Models of Structures in Didactics
PublicationThe final aim of teaching students subjects, such as structural mechanics, reinforced concrete, and steel structures is to teach them how structures work in a given building as well as to provide them with skills enabling them to calculate and design structures. The behavioral model of the structure, contrary to the architectural model, which focuses mainly on the external form of the building, shows workings from both the static...
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Analysis of the Environmental Impact of the Hull Construction of a Small Vessel Based on LCA
PublicationIn recent years, issues related to the impact of human activity on the natural environment have become pressing, and the challenge of global warming necessitates immediate action. To support environmental protection efforts, it has become imperative to adopt a broader perspective when evaluating various products and systems. A valuable tool for such assessments is a life cycle assessment (LCA), which enables a comprehensive analysis...
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Virtual Whiteboard: A gesture-controlled pen-free tool emulating school whiteboard
PublicationIn the paper the so-called Virtual Whiteboard is presented which may be an alternative solution for modern electronic whiteboards based on electronic pens and sensors. The presented tool enables the user to write, draw and handle whiteboard contents using his/her hands only. An additional equipment such as infrared diodes, infrared cameras or cyber gloves is not needed. The user's interaction with the Virtual Whiteboard computer...
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Connected early-career experiences of equality in academia during the pandemic and beyond: Our liminal journey
PublicationIn this paper, we draw on our subjective experiences as two female early-career academics during the global COVID-19 pandemic. While we acknowledge that the pandemic had negative implications for many female scholars due to compulsory telework or increased family responsibilities, we also want to shed light on the empowering experiences shaped by collegial support that became an important part of our pandemic story. We build on...
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Ocena stanu technicznego konstrukcji zgarniaczy będących na wyposażeniu osadników wstępnych Grupowej Oczyszczalni Ścieków „DĘBOGÓRZE
PublicationOsadniki wstępne typu DORRA – 4 szt., o pojemności 1830 m3, wyposażone są w elementy mechaniczne do kierunkowego przemieszczania się osadu w kierunku leja centralnego. Celem pracy jest ocena stany technicznego części mechanicznej, a w szczególności: - konstrukcji zespołu zgarniania części pływających oraz osadu. - zespołu napędu i sterowania, - zespołu napędu i jazdy. Pierwsze dwa zespoły będą oceniane również z punktu widzenia...
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MnCo2O4 deposited by spray pyrolysis as a protective layer for stainless steel interconects
PublicationStainless steel interconnects working in Solid Oxide Fuel Cells stacks are exposed to high temperature resulting in their corrosion. Protective layers for the hydrogen and oxygen sides are necessary to protect the interconnect material, prolongate the stack lifetime and maintain the output power. In this paper MnCo2O4 protective layer for the oxygen side of the interconnect is deposited by spray pyrolysis and is examined.
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A new approach to the prosthetic finger design
PublicationW pracy zaprezentowano nowy sposób projektowania protez ręki przy użyciu aplikacji CAD. Uzyskano projekt palca wskazującego, w którym zaproponowano napęd poszczególnych członów w oparciu o stopy z pamięcią kształtu.
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Comparison of the content of phenolic compounds and antioxidant activity of white, red and black currants (Ribes sp.) extracts
PublicationThe aim of this study was to compare the content of antioxidant compounds and the antioxidant activity of extracts from white, red and black currants (Ribes sp.). The chemical properties verified included determinations of anthocyanins and other phenols by HPLC-DAD-MS, total antioxidant activity by standard spectrophotometric tests (ABTS, DPPH and FCR), and profiles of antioxidants by TLC with visualization reagents (ABTS, DPPH,...
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Determination of chlorophenols and phenoxyacid herbicides in the Gulf of Gdańsk, Southern Baltic Sea.
PublicationChlorofenole i kwasy fenoksyoctowe to dwie grupy zanieczyszczeń środowiska, obecne w wodach powierzchniowych. Kwasy fenoksyoctowe, ze względu na dobrą rozpuszczalność w wodzie, stosunkowo łatwo przedostają się do zbiorników wodnych i innych elementów środowiska. W ramach pracy postanowiono zbadać zawartość chlorofenolu i kwasów fenoksyoctowych oraz ich sezonowe zmiany w wodach ujścia Wisły i Zatoki Gdańskiej. Opracowano metodę...
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Keratinocyte-derived small extracellular vesicles supply antigens for CD1a-resticted T cells and promote their type 2 bias in the context of filaggrin insufficiency
PublicationIntroduction: Exosome-enriched small extracellular vesicles (sEVs) are nanosized organelles known to participate in long distance communication between cells, including in the skin. Atopic dermatitis (AD) is a chronic inflammatory skin disease for which filaggrin (FLG) gene mutations are the strongest genetic risk factor. Filaggrin insufficiency affects multiple cellular function, but it is unclear if sEV-mediated cellular communication...
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Expert media approach to hearing aids fitting
PublicationW artykule zaprezentowano problematykę dopasowania protez słuchu. Przedstawiono system ekspercki, który pozwala na znalezienie charakterystyk aparatu słuchowego adekwatnego do uszkodzenia słuchu. System został oparty o metodę zbiorów przybliżonych i logikę rozmytą.
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Automatic assessment of the hearing aid dynamics based on fuzzy logic
PublicationPrzedstawiono podstawy koncepcyjne systemu dopasowania protez słuchu opartego na logice rozmytej. Przeprowadzono dyskusje na temat metody skalowania głośności. Następnie podano szczegóły procesu aproksymacji funkcji przynależności odzwierciedlające słuchowe wrażenia głośności. Załączono wnioski.
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A mechanistically approached review upon assorted cell lines stimulated by athermal electromagnetic irradiation
PublicationThe probable influence of electromagnetic irradiation on cancer treatment has been deduced from the interaction of artificial electromagnetic emissions with biological organisms. Nonetheless, the suspected health effects induced by electromagnetic-based technology imply that such a treatment may contaminate the adjacent healthy cells. Thus, gaining mechanistic insights into the problem is required to avoid athermal health hazards....
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Władysław Tatarkiewicz, Szkoła marburska i jej idealizm
PublicationKsiążka Władysława Tatarkiewicza zatytułowana Szkoła marburska i jej idealizm składa się z pięciu artykułów poświęconych marburskiej filozofii neokantowskiej oraz tekstów czterech recenzji dotyczących rozpraw filozofów z Marburga. Teksty te zostały napisane i opublikowane w polskich czasopismach filozoficznych tuż po powrocie Tatarkiewicza do kraju z prowadzonych pod kierunkiem Hermanna Cohena i Paula Natorpa studiów w Marburgu...
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Tereny polarne - interesującym obszarem do badań Cz. II - Analityka próbek abiotycznych w Arktyce
PublicationW pracy ujęto problematykę zanieczyszczeń obszarów polarnych. Zwrócono szczególną uwagę na trwałe związki organiczne obecne w rejonie Arktyki w elementach przyrody nieożywionej. TZO pochodzenia antropogenicznego mogą pojawiać się na terenach polarnych za sprawą transportu na duże odległości z obszarów Euroazji i Ameryki Północnej. Badania poziomów zanieczyszczeń obecnych w próbkach abiotycznych na obszarze Arktyki stanowią fundament...
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Kod fontannowy z przyrastającą liczbą symboli źródłowych
PublicationKody fontannowe zabezpieczające transmisję przed wymazaniami wyróżnia brak określonej z góry długości i losowy sposób generacji kolejnych pakietów kodowych. W pracy pokazano jak właściwości tych kodów zależą od rozkładu macierzy generującej dla dwóch wariantów dostarczania pakietów do kodera. Szczególnie interesujący jest przypadek, gdy pakiety źródłowe trafiają do kodera stopniowo podczas transmisji. Uzyskane wyniki wskazują na...
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Drop-coating deposition surface-enhanced Raman spectroscopy on silver substrates for biofluid analysis
PublicationUtilization of surface-enhanced Raman spectroscopy as a measurement technique is of particular interest in biodetection due to its superb chemical specificity and high sensitivity. The use of SERS substrates further improve this method by massive enhancement of the molecule Raman spectrum, permitting very low levels of detection. Therefore it is important to seek for new ways to develop reliable substrates, which are quickly and...
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Przydatność białka rybiego w postaci kolagenu lub żelatyny oraz polisacharydu - kapa-karagenu do wytwarzania aktywnych opakowań biodegradowalnych = Usefulness of fish collagen, gelatin and carrageenan for preparation of active biodegradable packages
PublicationSummary - The possibility of use of protein films made of fish collagen or gelatin as well as polysaccharide carrageenan films as carriers of enzymes (lysozyme or lysostaphyne), for preparation of microbiologically active packages, was investigated. It was found that crosslinking of such systems with N-[3(dimethylamino)propyl]-N'-ethylcarboimide (EDC) does not influence the activity of lysozyme immobilized in the films (Table 1)....
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Engineering Candida albicans glucosamine-6-phosphate synthase for efficient enzyme purification
PublicationRationally designed muteins of Candida albicans glucosamine-6-phosphate synthase, an enzyme known as a promising target for antifungal chemotherapy, were constructed, overexpressed in Escherichia coli and purified to near homogeneity. To facilitate and to optimize the purification of the enzyme, three recombinant versionscontaining internal oligoHis fragments were constructed: (i) by substituting residues 343 - 348...
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Photonic sensor to detect rapid changes in CRP levels
PublicationOne of the most important biomarkers used to determine inflammation is C-reactive protein (CRP). Its level, when it is within the range that does not define inflammation, informs about the risk of cardiovascular events. If the norm is exceeded and inflammation is detected in the body, CRP level can increase 1000 times within a few hours. The type of infection can also be determined based on the level of elevated CRP. All this makes...
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DMSO and TMAO—Differences in Interactions in Aqueous Solutions of the K-Peptide
PublicationInteractions between a solvent and their co-solute molecules in solutions of peptides are crucial for their stability and structure. The K-peptide is a synthetic fragment of a larger hen egg white lysozyme protein that is believed to be able to aggregate into amyloid structures. In this study, a complex experimental and theoretical approach is applied to study systems comprising the peptide, water, and two co-solutes: trimethylamide...
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Dynamic host configuration protocol for IPv6 improvements for mobile nodes
PublicationIn wireless networks mobile clients change their physical location, which results in changing point of attachment to the network. Such handovers introduce unwanted periods, when node does not have communication capabilities. Depending on many conditions, such events may require reconfiguration of layer 2 (e.g. IEEE 802.16) or both 2 and 3 layers (IPv6). This paper investigates delays introduced in the latter type of handover. IPv6...
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Modeling sequencing batch reactor operational conditions depending on oxygen concentration
PublicationSequencing batch reactors (SBR) can be used as a fill-and draw activated sludge system for wastewater treatment with considerable operating flexibility and the possibility to conduct experiments under standard conditions and extreme case scenarios. Mathematical modeling and computer simulations provide an opportunity to implement existing wastewater processes in modeling software and evaluate different modifications at low costs...
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Gość Inność, Wystawa sztuki współczesnej, Galeria MD_S, Wrocław 2019
PublicationGrudzień. Zimno, szaro, mokro, wszyscy biegają, żeby wyrobić się na święta; żeby kupić prezenty, odwiedzić rodzinę do której średnio chce Ci się jechać, żeby usiąść przy stole, odpowiadać na sztywne pytania w sztywnych koszulach, zapychając usta karpiem. Zapraszamy w gościnę do galerii MD_S 20 grudnia, gdzie o 18:00 będzie biła ciepłem i przytulnością, bo gościnność nie ocenia tak jak my nie oceniamy, każdy z nas jest gościem...
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Analysis of the Accuracy of Pulse Estimation Using Smart Watches
PublicationThe purpose of this paper is to perform an analysis of the accuracy of the pulse estimation by comparing readings from a smartwatch with readings from medical devices. The study required writing applications that allow continuous pulse measurement. As a result, two applications were created for the smartwatch. The first one is dedicated to Android Wear devices, while the other one is compatible with Tizen watches. The next step...
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Dynamic GNSS Mission Planning Using DTM for Precise Navigation of Autonomous Vehicles
PublicationNowadays, the most widely used method for estimating location of autonomous vehicles in real time is the use of Global Navigation Satellite Systems (GNSS). However, positioning in urban environments using GNSS is hampered by poor satellite geometry due to signal obstruction created by both man-made and natural features of the urban environment. The presence of obstacles is the reason for the decreased number of observed satellites...
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A method of selecting light sources from night satellite scenes
PublicationSatellite images carries a lot of data. Very sophisticated methods of analyses may reveal very complicated nature of the observed objects. In case of night images, lights play the role of information sources. In this paper we would like to present results of the research aimed to describe light sources from satellite night images by providing description of their luminosity. The authors point source imaging data from the satellite...
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Rewitalizacja Berlina i Lipska jako źródło inspiracji dla polskich praktyk rewitalizacyjnych
PublicationArtykuł odnosi się do możliwości wykorzystania niemieckich doświadczeń rewitalizacyjnych z okresu 1995-2015 w aktualnych uwarunkowaniach polskich. Wykorzystano fragment syntezy badań własnych prowadzonych na terenie Berlina i Lipska (partnerzy DASL, DAAD). Wnioski z analizy polskiej praktyki (współpraca z Miastem Łódź) posłużyły wyborowi przykładów dobrej praktyki z Berlina i Lipska zastosowanych w odmiennych uwarunkowaniach społeczno-gospodarczych....
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Four Degree-of-Freedom Hydrodynamic Maneuvering Model of a Small Azipod-Actuated Ship With Application to Onboard Decision Support Systems
PublicationThe main contribution of this paper is a numerical ship motion model of NTNU’s research vessel Gunnerus, capturing the surge, sway, roll, and yaw dynamics when sailing in uniform and steady currents. The model utilizes a crossflow drag formulation for the transverse viscous loads, and it includes a nonlinear formulation for the propulsion and steering loads provided by two azipod thrusters. A wide range of experimental data obtained...
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Greencoin: prototype of a mobile application facilitating and evidencing pro-environmental behavior of citizens
PublicationAmong many global challenges, climate change is one of the biggest challenges of our times. While it is one of the most devastating problems humanity has ever faced, one question naturally arises: can individuals make a difference? We believe that everyone can contribute and make a difference to the community and lives of others. However, there is still a lack of effective strategies to promote and facilitate pro-environmental...
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Bacterial cellulose in the field of wound healing and regenerative medicine of skin: recent trends and future prospectives
PublicationIn this overview, we focused on the bacterial cellulose (BC) applications, described in recently published scientific papers, in the field of skin regenerative medicine and wound care industry. Bacterial cellulose was proven to be biocompatible with living tissues. Moreover, its mechanical properties and porous structure are considered to be suitable for biomedical applications. It is due to the fact that porous structure of bacterial...
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Krajobraz nomadyczny w Muittalus samid birra (1910) Johana Turiego
PublicationThe article introduces Muittalus samid birra (1910, An account of the Sami) by Johan Turi, the fi rstbook with a secular content written in the sami language by a sami person. The author, a wolf hunterand reindeer-breeder, describes a broad spectrum of his people’s daily life. Pictures of everydayactivities are supplemented with stories about the sami people’s knowledge of the world (traditions,myths,...
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Proteomic and Metabolomic Changes in Psoriasis Preclinical and Clinical Aspects
PublicationSkin diseases such as psoriasis (Ps) and psoriatic arthritis (PsA) are immune-mediated inflammatory diseases. Overlap of autoinflammatory and autoimmune conditions hinders diagnoses and identifying personalized patient treatments due to different psoriasis subtypes and the lack of verified biomarkers. Recently, proteomics and metabolomics have been intensively investigated in a broad range of skin diseases with the main purpose...
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New Peptide Based Fluconazole Conjugates with Expanded Molecular Targets
PublicationInfections of Candida spp. etiology are frequently treated with azole drugs. Among azoles, the most widely used in the clinical scenario remains fluconazole (FLC). Promising results in treatment of dangerous, systemic Candida infections demonstrate the advantages of combined therapies carried out with combinations of at least two different antifungal agents. Here, we report five conjugates composed of covalently linked FLC and...
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Proces wytwarzania e-kursu. Studium przypadku.
PublicationArtykuł definiuje proces wytwarzania e-kursu i e-lekcji oraz kolejne jego etapy, zaczynając od okre - ślania celu i odbiorcy, a kończąc na udostępnieniu treści. Na podstawie opisanego procesu przedstawiane jest stu - dium przypadku dla e-kursu prowadzonego na studiach zaocznych na Wydziale ETI Politechniki Gdańskiej na przedmiocie Strategie informatyzacji. Artykuł pokazuje też ewaluację studium przypadku, zarówno na poziomie oceny...
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Measurement of benzene concentration in urban air using passive sampling
PublicationAbstract The concentration of benzene in urban air in theTri-City area of Poland (Gdańsk-Sopot-Gdynia, andTczew) was assessed using diffusive passive samplers (Rad-iello). Samples were collected during a four-year monitoringcampaign (2007-2010) at selected monitoring stations man-aged by the Agency of Regional Air Quality Monitoring inthe Gdańsk Metropolitan Area (ARMAAG) Foundation.The performance of the passive samplers was investigatedin...
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Rozdzielanie, identyfikacja i oznaczanie składników osadu z produkcji olejów jadalnych w warunkach NP-HPLC
PublicationPraca dotyczy badań nad wykorzystaniem rozdzielania w warunkach adsorpcyjnej w normalnych układach faz wysokosprawnej kolumnowej chromatografii cieczowej (NP - HPLC) w celu wyjaśnienia składu uciążliwego osadu tworzącego się w płytowym wymienniku ciepła jako jednego z modułów systemu przeznaczonego do odzysku nieskroplonego heksanu po ekstrakcji oleju z nasion. W badaniach wykorzystano spektrofotometrię w zakresie...
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Molecularly targeted nanoparticles: an emerging tool for evaluation of expression of the receptor for advanced glycation end products in a murine model of peripheral artery disease
PublicationAbstract Background: Molecular imaging with molecularly targeted probes is a powerful tool for studying the spatio-temporal interactions between complex biological processes. The pivotal role of the receptor for advanced glycation end products (RAGE) in numerous pathological processes, aroused the demand for RAGE targeted imaging in various diseases. In the study, we evaluated the use of a diagnostic imaging agent for RAGE quantification...