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Search results for: TENDENCJE WIELOROCZNE
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Properties of water in the region between a tubulin dimer and a single motor head of kinesin
PublicationA kinesin is a molecular motor that can perform movement on a microtubule track in a stepping-like manner. This motion is connected with processes of association and dissociation of kinesin and tubulin. Water is an important participant in these kinds of molecular interactions. This is why we have decided to investigate the dynamical and structural properties of water in the region between the kinesin catalytic domain and the tubulin...
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Theoretical Assessment of Excited State Gradients and Resonance Raman Intensities for the Azobenzene Molecule
PublicationThe ground state geometries and vibrational frequencies as well as the excitation energies and excited state gradients of the S 1(nπ*) and S 2(ππ * ) states of trans - and cis -azobenzene are investigated by several DFT methods, namely B3LYP, PBE, M06-2X, CAM-B3LYP, and ω B97X. Excited state properties and in particular gradients are also assessed using the wave function based methods EOM-CCSD and RASPT2/RASSCF. Comparison with...
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Linking optical and electronic properties to photoresponse of heterojunctions based on titania nanotubes and chromium, molybdenum, and tungsten oxides
PublicationThe development of photosensitization strategies for titanium dioxide is necessary for the enhancement of its optical and electronic properties towards its application potential in solar photoelectrochemistry. In this work, significant differences in the photosensitizing capability of the 6th group transition metal oxides applied on the surface of titania nanotubes are reported. For the first time, correlations between the experimentally...
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Exploring the influence of personal factors on physiological responses to mental imagery in sport
PublicationImagery is a well-known technique in mental training which improves performance efficiency and influences physiological arousal. One of the biomarkers indicating the amount of physiological arousal is skin conductance level (SCL). The aim of our study is to understand how individual differences in personality (e.g. neuroticism), general imagery and situational sport anxiety are linked to arousal measuring with SCL in situational...
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How acidic amino acid residues facilitate DNA target site selection
PublicationDespite the negative charge of the DNA backbone, acidic residues (Asp/Glu) commonly participate in the base readout, with a strong preference for cytosine. In fact, in the solved DNA/protein structures, cytosine is recognized almost exclusively by Asp/Glu through a direct hydrogen bond, while at the same time, adenine, regardless of its amino group, shows no propensity for Asp/Glu. Here, we analyzed the contribution of Asp/Glu...
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Chemically reduced graphene oxide based aerogels - Insight on the surface and textural functionalities dependent on handling the synthesis factors
PublicationEfficient adjusting of reduced graphene oxide aerogels properties requires information about experimental factor-aerogel property relationship. In this work, the reduced graphene oxide aerogels surface and textural functionalities in relation to precursor concentration, gelation time and hydrogel freezing temperature were studied in detail, with the use of dynamic adsorption method of gaseous organic probes and experimental design....
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Why do G-quadruplexes dimerize through the 5’-ends? Driving forces for G4 DNA dimerization examined in atomic detail
PublicationG-quadruplexes (G4) are secondary structures formed by guanine-rich nucleic acid sequences and shown to exist in living cells where they participate in regulation of gene expression and chromosome maintenance. G-quadruplexes with solvent-exposed guanine tetrads show the tendency to associate together through cofacial stacking, which may be important for packaging of G4-forming sequences and allows for the design of higher-order...
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HILS for the Design of Three-Wheeled Mobile Platform Motion Surveillance System with a Use of Energy Performance Index
PublicationCurrent tendency in mechatronic design requires the use of comprehensive development of an environment, which gives the possibility to prototype, design, simulate and integrate with dedicated hardware. The paper discusses the Hardware-In-the-Loop Simulations (HILS) mechatronic technique, used during the design of the surveillance system based on energy performance index. The presented test configuration (physical controller – emulated...
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Preliminary Testing of the Influence of Modified Polycaprolactones on Anabaena Variabilis Growth in Seawater
PublicationSeveral new biodegradable polymer materials have recently come onto the global market. Mostly the results on degradation kinetic studies are presented. This paper suggests using one of the tests to estimate the impact of polymer packaging material on sea life. The microorganism chosen was Anabaena variabilis (identified in many waters, including those of the Baltic Sea, especially in the Gulf of Gdansk and Puck Bay; this cyanobacterium...
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Thermodynamics and kinetics of amphotericin B self-association in aqueous solution characterized in molecular detail
PublicationAmphotericin B (AmB) is a potent but toxic drug commonly used to treat systemic mycoses. Its efficiency as a therapeutic agent depends on its ability to discriminate between mammalian and fungal cell membranes. The association of AmB monomers in an aqueous environment plays an important role in drug selectivity, as oligomers formed prior to membrane insertion – presumably dimers – are believed to act differently on fungal (ergosterol-rich)...
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Processing, physico-mechanical and thermal properties of reclaimed GTR and NBR/reclaimed GTR blends as function of various additives
PublicationIn this work, ground tire rubber (GTR) was mechano-chemically reclaimed in the presence of bitumen and various additives. During studies three types of processing and curing additives: (i) peptizer P300; (ii) vulcanization accelerator tetramethylthiuram disulfide (TMTD) and (iii) organic peroxide di(2-tert-butyl-peroxyisopropyl)benzene (BIB1) were applied to enhance reclaiming of GTR. Reclaiming process was evaluated by oscillating...
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Experimental and numerical analysis of the pyrolysis dynamics of a single wood particle: presentation of the radiographic technique
PublicationPyrolysis is an oxygen-free process for the thermal decomposition of raw materials. The heat conduction and flow of pyrolysis products (i.e., the gas fraction and liquid vapour generated during pyrolysis) influence the process and products. In this work, the influence of the orientation of wooden particle fibres with respect to the direction of the heat source on the dynamics of the process was investigated, where there were two...
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Niobate in silicate and phosphate glasses: Effect of glass basicity on crucible dissolution
PublicationUsing niobium crucibles for melting phosphate and silicate glasses of various modifier oxide contents, and therefore varying optical basicity (Λ), was found to result in varying dissolution rates of niobate during melting. Because of their high electronic polarizability, even small concentrations of niobates are detectable in the Raman spectra of glasses. Even less than 1 mol% Nb2O5 can be identified, as independently confirmed...
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Bariery rozwoju przedsiębiorczości – analiza retrospektywna i porównawcza z innymi krajami Europy
PublicationCelem niniejszego artykułu jest ocena retrospektywna zmian w tym okresie, w zakresie opinii przedsiębiorców dotyczących najistotniejszych przeszkód w podejmowaniu i prowadzeniu działalności, oraz dokonanie analizy porównawczej z podobnymi badaniami, w innych krajach Europy, w celu wskazania, czy i w jakim zakresie różnią się te bariery w innych gospodarkach oraz czy są one również postrzegane w podobnym stopniu przez polskie środowisko...
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Minimalizm jako metoda twórcza w architekturze współczesnej na wybranych przykładach z lat 1990-2005
PublicationPunktem wyjścia do pracy nad niniejszą książką była zaobserwowana zarówno w języku krytyki architektonicznej jak i w języku potocznym tendencja do utożsamiania, a za tym ograniczania, znaczenia architektonicznego minimalizmu do jego aspektu wizualnego. Niemal każde formalne lub stylistyczne uproszczenie wpisane zostaje w jakiś szeroki nurt minimalizmu, a prosty wygląd architektury stał się jego podstawowym kryterium klasyfikacyjnym....
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Dyfuzyjne spalanie turbulentne metanu w strudze: analiza numeryczna płomienia Sandia D
PublicationDyfuzyjne spalanie turbulentne jest najpowszechniej występującym w zastosowa-niach przemysłowych rodzajem tego procesu. Jednak jego dokładny opis wciąż sprawia trudności i obserwuje się rozwój konkurujących modeli implementowanych w podejściu RANS (Reynolds Averaged Navier Stokes), a współcześnie coraz częściej także w metodzie dużych wirów (LES) o czym świadczą liczne publikacje [13, 16, 18, 21]. W niniejszej pracy przedstawiono...
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Wiadukt łukowy w Białymstoku
PublicationReferat prezentuje oddany do użytkowania w czerwcu 2011 wiadukt drogowy ,,Łuk Białostocki”. Konstrukcja ta z uwagi na lokalizację dźwigara łukowego względem osi pomostu – po przekątnej, jest w Polsce w swojej skali obiektem prototypowym. Ustrój nośny obiektu stanowi stalowy bezprzegubowy dźwigar łukowy, usytuowany w rzucie z góry po krótszej przekątnej konstrukcji, z podwieszonym za pomocą cięgien pomostem zespolonym. Rozpiętość...
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Co stymuluje rozwój współczesnej teleinformatyki i jakie są istotne kierunki tego rozwoju?
PublicationCorocznie dokonuje się oceny stanu sztuki i tendencji w rozwoju światowej telekomunikacji i (tele)informatyki przywołując „mierzalne” i „niemierzalne” zmiany. W artykule przedstawiono charakter tych zmian oraz wskazano wyzwania badawcze i wdrożeniowe istotne dla rozwoju tych dyscyplin. Zaprezentowano i scharakteryzowano ewolucję infrastruktury sieciowej prowadzącą do sieci programowalnych SDN (Software Defined Network) oraz wykorzystania...
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Nanosilver-loaded PMMA bone cement doped with different bioactive glasses – evaluation of cytocompatibility, antibacterial activity, and mechanical properties
PublicationNanosilver-loaded PMMA bone cement (BC-AgNp) is a novel cement developed as a replacement for conventional cements. Despite favorable properties and antibacterial activity, BC-AgNp still lacks biodegradability and bioactivity. Hence, we investigated the doping with bioactive glasses (BGs) to create a new bioactive BC characterized by time-varying porosity and gradual release of nanosilver. The BC Cemex was used as the base material...
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In-depth characterization of icosahedral ordering in liquid copper
PublicationThe presence of icosahedral ordering in liquid copper at temperatures close to the melting point is now well-established both experimentally and through computer simulation. However, a more elaborate analysis of local icosahedral and icosahedron-like structures, together with a system for classifying such structures based on some measure of "icosahedrity", has so far been conspicuously absent in the literature. Similarly, the dynamics...
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PTD4 Peptide Increases Neural Viability in an In Vitro Model of Acute Ischemic Stroke
PublicationIschemic stroke is a disturbance in cerebral blood flow caused by brain tissue ischemia and hypoxia. We optimized a multifactorial in vitro model of acute ischemic stroke using rat primary neural cultures. This model was exploited to investigate the pro-viable activity of cell-penetrating peptides: arginine-rich Tat(49–57)-NH2 (R49KKRRQRRR57-amide) and its less basic analogue, PTD4 (Y47ARAAARQARA57-amide). Our model included glucose...
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Functionalized Peptide Fibrils as a Scaffold for Active Substances in Wound Healing
PublicationTechnological developments in the field of biologically active peptide applications in medicine have increased the need for new methods for peptide delivery. The disadvantage of peptides as drugs is their low biological stability. Recently, great attention has been paid to self-assembling peptides that can form fibrils. Such a formulation makes bioactive peptides more resistant to enzymatic degradation and druggable. Peptide fibrils...
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Isolation of the relative decrease in magnetic permeability contribution to reluctance of an open magnetic circuit based on stray field measurements
PublicationThe goal of the study was to evaluate a relative decrease in magnetic permeability in open magnetic circuits based on stray magnetic field measurements. The boundary element method was used to simulate magnetic circuits with variable geometry and variable magnetic permeability. The simulated magnetic circuits were rectangular or bone-shaped flat samples. Reluctance was increased in the middle of the samples resulting in leakage...
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Inhibiting activity of HIV-1: protease, reverse transcriptase and integrase all together by novel compounds using computational approaches (flexible and rigid docking)
PublicationAcquired immunodeficiency syndrome (AIDS), caused by human immunodeficiency virus type 1 (HIV-1) infection, is one of the most challenging diseases in recent decades. Nevertheless the shortcomings of chemical drugs such as toxicity, lack of curative effects, the search for more potent anti-HIV agents have been focused in our study. In current study, novel scaffold was designed having a benzyl and imidazole in it which are very...
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Expression of cyclin D1 after treatment with doxorubicin in the HL-60 cell line
PublicationIncreased levels of cyclin D1 and amplification of CCND1 gene occur in many types of cancers. We have followed the expression of cyclin D1 after treatment with doxorubicin with reference to cell death and other possible therapeutic implications. The effect of the treatment on the cell cycle, survival, intracellular level (flow cytometry), and intracellular localization of cyclin D1 (fluorescence microscopy) and expression of...
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Management Strategy for Seaports Aspiring to Green Logistical Goals of IMO: Technology and Policy Solutions
PublicationRecently, because of serious global challenges including the consumption of energy and climate change, there has been an increase in interest in the environmental effect of port operations and expansion. More interestingly, a strategic tendency in seaport advancement has been to manage the seaport system using a model which balances environmental volatility and economic development demands. An energy efficient management system...
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Is mesh fixation necessary in laparoendoscopic techniques for M3 inguinal defects? An experimental study.
Publicationrepairs, in case of large direct hernias (M3) mesh fixation is recommended to reduce recurrence risk. Despite lack of highquality evidence, the recommendation was upgraded to strong by expert panel. The authors conducted a research experiment to verify the hypothesis that it is possible to preserve the mesh in the operating field in large direct hernias (M3) without the need to use fixing materials. Method The authors conducted...
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Przemiany przestrzenne przedmieść i wsi, a oczekiwania społeczne w okresie po 1989 roku w Polsce
PublicationRozwój miast na przestrzeni wieków to zmieniający się krajobraz, który ewoluuje wraz ze zmianami funkcjonalnymi miast i pojawianiem się coraz to nowych w nim elementów będących konsekwencją postępu technicznego oraz społecznego. Oczekiwania użytkowników przestrzeni zmieniają się i ewoluują równolegle z przekształceniami na płaszczyźnie społecznej, ekonomicznej, kulturowej czy przestrzennej. Spowodowane są zarówno potrzebami, jak...
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Small Hydropower Plants in Pomerania: The Example of Evolution of Modern Industrial Brick Architecture
PublicationModernism is usually recognized and associated with the aesthetics of the International Style, represented by white-plastered, horizontally articulated architecture with skimpy decoration, where function was the main imperative of the architects’ ambitions. The brick face of Modernism in Northern Europe reflected, in fact, the complexity of the modern change, breaking ties with the historic styles of the 19th century and being...
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Numeryczna analiza możliwości zwiększenia efektywności grzewczej pompy ciepła, poprzez modyfikację skraplacza
PublicationW niniejszej pracy określono charakterystykę prostego modelu wymiennika ciepła bazującego na skraplaczu powietrznej pompy ciepła. Jest to helikoidalny rekuperator typu rura w rurze. Zaproponowano i poddano analizie numerycznej dwie metody intensyfikacji wymiany ciepła i zestawiono wyniki z modelem porównawczym. Zastosowane rozwiązania zwiększające strumień wymienianego ciepła spowodowały wzrost odbieranego przez wodę strumienia...
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Changes in the addiction prevalence in Polish population between 1990-2019: Review of available data
PublicationThe 1989 collapse of the socialist political system in Poland initiated an avalanche of modifications regarding healthcare policy resulting with new institutions and programs dedicated to monitoring and preventing addiction. In the current article, we look at the available data allowing to track changes in (1) the prevalence of exposure to addictive substances and behaviors, and (2) changes of addictions prevalence in Poland...
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Exploring the preferences of Polish EFL teachers towards the accents of English
PublicationThis language attitudes study investigates the preferences of EFL (English as a foreign language) teachers from Poland towards the accents of English they speak and teach. Despite the substantial amount of research on EFL learners, little has been done to investigate the impact of preferences of Polish teachers for different variations of English language on their...
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FAILURE OF MAGNETIC FLUID SEALS OPERATING IN WATER: PRELIMINARY CONCLUSIONS
PublicationThe article analyses properties of magnetic fluid seals installed in rotary sealing no des which operate in the utility water environment. Seals of this type have been examined as a possible solution to the problem with ship manoeuvring propulsion sealing. The present analysis bases on laboratory durability tests of magnetic fluid seals expo sed to long - term utility water loads, at different water pressures and shaft revolutions....
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A Novel Cryptic Clostridial Peptide That Kills Bacteria by a Cell Membrane Permeabilization Mechanism
PublicationThis work reports detailed characteristics of the antimicrobial peptide Intestinalin (P30), which is derived from the LysC enzyme of Clostridium intestinale strain URNW. The peptide shows a broader antibacterial spectrum than the parental enzyme, showing potent antimicrobial activity against clinical strains of Gram-positive staphylococci and Gram-negative pathogens and causing between 3.04 ± 0.12 log kill for Pseudomonas aeruginosa...
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Combined anticancer therapy with imidazoacridinone analogue C‐1305 and paclitaxel in human lung and colon cancer xenografts—Modulation of tumour angiogenesis
PublicationThe acridanone derivative 5-dimethylaminopropylamino- 8- hydroxytriazoloacridinone (C-1305) has been described as a potent inhibitor of cancer cell growth. Its mechanism of action in in vitro conditions was attributed, among others, to its ability to bind and stabilize the microtubule network and subsequently exhibit its tumour- suppressive effects in synergy with paclitaxel (PTX). Therefore, the objective of the present study...
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Emerging strategies for enhancing detection of explosives by artificial olfaction
PublicationExplosives detection systems need to be able to reliably detect a wide range of explosive materials and their vapours. The continued development and improvement of artificial olfaction techniques, including electronic nose (EN), remains important to overcome existing challenges and meet requirements posed by new improvements in the field of explosives. There is an increasingly popular trend aimed at improvement of fundamental metrological...
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Dual-Activity Fluoroquinolone-Transportan 10 Conjugates offer alternative Leukemia therapy during Hematopoietic Cell Transplantation
PublicationHematopoietic cell transplantation (HCT) is often considered a last resort leukemia treatment, fraught with limited success due to microbial infections, a leading cause of mortality in leukemia patients. To address this critical issue, we explored a novel approach by synthesizing antileukemic agents containing antibacterial substances. This innovative strategy involves conjugating fluoroquinolone antibiotics, such as ciprofloxacin...
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Elektro- i magnetomodulacja dysocjacji ekscytonów w organicznych układach jednoskładnikowych i dwuskładnikowych typu donor elektronu - akceptor elektronu
PublicationW ramach rozprawy doktorskiej przeprowadzono badania procesu dysocjacji stanów wzbudzenia elektronowego w układach molekularnych jedno- i dwuskładnikowych typu donor elektronu - akceptor elektronu. Do tego celu wykorzystano technikę spektroskopii elektro- i magnetomodulacyjnej wykonując pomiary zarówno fotoprądu, jak i elektromodulowanej fotoluminescencji. Spektroskopia magnetomodulacyjna okazała się skutecznym narzędziem do opisu...
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Testing Students’ Entrepreneurial Self-Efficacy as an Early Predictor of Entrepreneurial Activities. Evidence From the SEAS Project
PublicationOver the last forty years, since Bandura (1977) introduced the concept of self-efficacy, there have been a constantly growing number of research publications using this concept. Its early development resulted in the creation of a new construct of entrepreneurial self-efficacy (ESE) proposed for the first time by (Chen et al. 1998). Since then, many different groups of research concerning ESE have emerged - one of them is the study...
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On the Possibility of the Amphotericin B-Sterol Complex Formation in Cholesterol- and Ergosterol-Containing Lipid Bilayers: A Molecular Dynamics Study
PublicationAmphotericin B (AmB) is a well-known membrane-active antibiotic that has been used to treat systemicfungal infections for more than 45 years. Therapeutic application of AmB is based on the fact that it is moreactive against ergosterol-containing membranes of fungal cells than against mammalian membranes withcholesterol. In this paper, we examine the hypothesis according to which the selectivity of the AmB's membraneaction originates...
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Strength analysis of a large-size supporting structure for an offshore wind turbine
PublicationThe offshore wind power industry is the branch of electric energy production from renewable sources which is most intensively developed in EU countries. At present, there is a tendency to install larger-power wind turbines at larger distances from the seashore, on relatively deep waters. Consequently, technological solutions for new supporting structures intended for deeper water regions are undergoing rapid development now. Various...
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Musical inspiration in contemporary architecture - to build a music and to hear an architecture
PublicationThe goal of this research is chosen from a wide range of subjects within two fields of knowledge on the crossroads between music and architecture There are many designs in modern contemporary architecture that would illustrate the relationship between music and architecture, mainly through musical inspiration. The article shows contemporary musical and architectural discussion that cross over from the theoretical to the practical...
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Between therapy effect and false-positive result in animal experimentation
PublicationDespite the animal models’ complexity, researchers tend to reduce the number of animals in experiments for expenses and ethical concerns. This tendency makes the risk of false-positive results, as statistical significance, the primary criterion to validate findings, often fails if testing small samples. This study aims to highlight such risks using an example from experimental regenerative therapy and propose a machine-learning...
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Największe osiedle mieszkaniowe międzywojennego Gdańska - stan obecny i perspektywy zachowania
PublicationZaprezentowane przykłady budynków modernistycznych pochodzą z największego gdańskiego osiedla mieszkaniowego z okresu dwudziestolecia międzywojennego – Osiedla Kościuszki. W analizowanym zespole zabudowy przeważa architektura mieszkaniowa wielorodzinna w zabudowie ciągłej. Chociaż charakteryzuje ją prostota i zharmonizowanie form, to poszczególne grupy budynków tworzące samodzielne podjednostki osiedla różnią się sposobem opracowania...
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Największe osiedle mieszkaniowe międzywojennego Gdańska - stan obecny i perspektywy zachowania
PublicationZaprezentowane przykłady budynków modernistycznych pochodzą z największego gdańskiego osiedla mieszkaniowego z okresu dwudziestolecia międzywojennego – Osiedla Kościuszki. W analizowanym zespole zabudowy przeważa architektura mieszkaniowa wielorodzinna w zabudowie ciągłej. Chociaż charakteryzuje ją prostota i zharmonizowanie form, to poszczególne grupy budynków tworzące samodzielne podjednostki osiedla różnią się sposobem opracowania...
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SKYSCRAPER'S PUBLIC AREAS: THE IMPACT ON SPACE AND SOCIAL LIFE
PublicationIn recent years, more careful consideration is taken into social issues of designing skyscrapers by humanizing adherent internal and external public areas. Case studies of The Shard (London: 2012), 122 Leadenhall Street (London: 2014), 20 Fenchurch Street (London: 2014), Heron Tower (London: 2011), Tower 25 (Nicosia: 2013), Zoofenster (Berlin: 2012), DNB House (Oslo: 2012), Centrum Biurowe Neptun (Gdansk, 2014), Skytower (Wroclaw:...
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Why do Open Government Data initiatives fail in developing countries? A root cause analysis of the most prevalent barriers and problems
PublicationOpen government data (OGD) include the provision of government data, which have so far been reserved for the provision of public utilities and services, wherein different stakeholders may create value out of the same source. Recently, OGD initiatives around the world have dampened or were found to be inadequate for one or other reasons. The present study seeks to underline the root causes behind these inadequate or stalled initiatives...
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An insight into the mixed quantum mechanical-molecular dynamics simulation of a ZnII-Curcumin complex with a chosen DNA sequence that supports experimental DNA binding investigations
PublicationAn important aspect of research pertaining to Curcumin (HCur) is the need to arrest its degradation in aqueous solution and in biological milieu. This may be achieved through complex formation with metal ions. For this reason, a complex of HCur was prepared with ZnII, that is not likely to be active in redox pathways, minimizing further complications. The complex is monomeric, tetrahedral, with one HCur, an acetate and a molecule...
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Underwater wet welding of S1300 ultra-high strength steel
PublicationMarine Structures Volume 81, January 2022, 103120 Underwater wet welding of S1300 ultra-high strength steel Author links open overlay panelJacekTomkówGrzegorzRogalski https://doi.org/10.1016/j.marstruc.2021.103120 Get rights and content Under a Creative Commons licenseopen access Highlights • Technological method of S1300 steel underwater weldability improving was proposed. • Number of cracks and hardness of welded joints was...
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Interspecific and intraspecific variation in organochlorine pesticides and polychlorinated biphenyls using non-destructive samples from Pygoscelis penguins
PublicationAs humans are present in Antarctica only for scientific and tourism-related purposes, it is often described as a pristine region. However, studies have identified measurable levels of Persistent Organic Pollutants (POPs), such as organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs), in the Antarctic region. These are highly toxic anthropogenic compounds with tendency to travel long distances and reach remote environments, where...