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Search results for: PROTEOMIKA
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Proteomic strategies in research on the cardiovascular system
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Proteomic and bioinformatic analysis of a nuclear intrinsically disordered proteome
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Proteomic and Metabolomic Changes in Psoriasis Preclinical and Clinical Aspects
PublicationSkin diseases such as psoriasis (Ps) and psoriatic arthritis (PsA) are immune-mediated inflammatory diseases. Overlap of autoinflammatory and autoimmune conditions hinders diagnoses and identifying personalized patient treatments due to different psoriasis subtypes and the lack of verified biomarkers. Recently, proteomics and metabolomics have been intensively investigated in a broad range of skin diseases with the main purpose...
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Proteomic Analysis of Proton Beam Irradiated Human Melanoma Cells
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Trial Proteomic Qualitative and Quantitative Analysis of the Protein Matrix of Submandibular Sialoliths
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Analyze of Maldi-TOF Proteomic Spectra with Usage of Mixture of Gaussian Distributions
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Quantitative proteomic analysis of anticancer drug RH1 resistance in liver carcinoma
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Proteomic and lipidomic biomarkers in the diagnosis and progression of inflammatory bowel disease – a review
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Transcriptomic and proteomic analysis of mouse radiation-induced acute myeloid leukaemia (AML)
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Potential plasma biomarkers of bladder cancer identified by proteomic analysis: A pilot study
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Mathematical Modelling and Effect Size Analysis in Support of Searching for the Proteomic Signature of Radiotherapy Toxicity
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Comparison of different digestion methods for proteomic analysis of isolated cells and FFPE tissue samples
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Proteomic profiling of exosomes derived from pancreatic beta-cells cultured under hyperglycemia
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Optimized procedure of extraction, purification and proteomic analysis of nuclear proteins from mouse brain
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Comparison of protein precipitation methods for various rat brain structures prior to proteomic analysis
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Proteomic-Biostatistic Integrated Approach for Finding the Underlying Molecular Determinants of Hypertension in Human Plasma
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Hyperosmolarity adversely impacts recombinant protein synthesis by Yarrowia lipolytica—molecular background revealed by quantitative proteomics
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Mass Spectrometry-Based Proteomic Characterization of Cutaneous Melanoma Ectosomes Reveals the Presence of Cancer-Related Molecules
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Proteomic profile of melanoma cell‐derived small extracellular vesicles in patients’ plasma: a potential correlate of melanoma progression
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Deciphering priming-induced improvement of rapeseed (Brassica napus L.) germination through an integrated transcriptomic and proteomic approach
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Stathmin reduction and cytoskeleton rearrangement in rat nucleus accumbens in response to clozapine and risperidone treatment – Comparative proteomic study
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Joint Genomic and Proteomic Analysis Identifies Meta-Trait Characteristics of Virulent and Non-virulent Staphylococcus aureus Strains
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Comparative Proteomic Analysis of Serum from Pigs Experimentally Infected with Trichinella spiralis, Trichinella britovi, and Trichinella pseudospiralis
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Clozapine influences cytoskeleton structure and calcium homeostasis in rat cerebral cortex and has a different proteomic profile than risperidone
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Comparison of mass spectrometry data and bioinformatics predictions to assess the bona fide localization of proteins identified in cell wall proteomics studies
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Three Microbial Musketeers of the Seas: Shewanella baltica, Aliivibrio fischeri and Vibrio harveyi, and Their Adaptation to Different Salinity Probed by a Proteomic Approach
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Proteomic Profiling of Ectosomes Derived from Paired Urothelial Bladder Cancer and Normal Cells Reveals the Presence of Biologically-Relevant Molecules
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Comparative Proteomic Profiling of Ectosomes Derived from Thyroid Carcinoma and Normal Thyroid Cells Uncovers Multiple Proteins with Functional Implications in Cancer
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Proteomic analysis of stipe explants reveals differentially expressed proteins involved in early direct somatic embryogenesis of the tree fern Cyathea delgadii Sternb
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Dietary chicory root and chicory inulin trigger changes in energetic metabolism, stress prevention and cytoskeletal proteins in the liver of growing pigs – a proteomic study
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“Biological Adhesion” is a Significantly Regulated Molecular Process during Long-Term Primary In Vitro Culture of Oviductal Epithelial Cells (Oecs): A Transcriptomic and Proteomic Study
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Kompletna dwuwymiarowa chromatografia gazowa - nowoczesne narzędzie analityczne - cz. III. Zastosowania i kierunki rozwoju
PublicationTechnika GC×GC znajduje szerokie zastosowanie w takich obszarach badawczych jak: przemysł petrochemiczny, ochrona środowiska, przemysł kosmetyczny i perfumeryjny, analiza żywności, analiza kliniczna, badania kosmiczne (np. analiza fragmentów meteorytów), metabolomika (np. badanie ludzkiego oddechu) i proteomika (np. identyfikacja białek w próbkach biologicznych) oraz kryminalistyka. W artykule przedstawiono przykłady zastosowań...
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Tissue fixed with formalin and processed without paraffin embedding is suitable for imaging of both peptides and lipids by MALDI-IMS
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Detection of molecular signatures of oral squamous cell carcinoma and normal epithelium - application of a novel methodology for unsupervised segmentation of imaging mass spectrometry data
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Real-Time Volatilomics: A Novel Approach for Analyzing Biological Samples
PublicationThe use of the ‘omics techniques in environmental research has become common-place. The most widely implemented of these include metabolomics, proteomics, genomics, and transcriptomics. In recent years, a similar approach has also been taken with the analysis of volatiles from biological samples, giving rise to the so-called ‘volatilomics’ in plant analysis. Developments in direct infusion mass spectrometry (DI-MS) techniques have...
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Kolumnowa chromatografia cieczowa w rozdzielaniu i analizie peptydów i białek
PublicationSzybka ekspansja zastosowań peptydów i białek w biochemii i w medycynie, stymuluje ogromny wzrost zainteresowania metodami rozdzielania peptydów. Elektroforeza żelowa i kapilarna to najczęściej dotychczas wykorzystywane metody rozdzielania peptydów i białek, w celach identyfikacyjnych i analitycznych. Metody te nie są jednak przydatne do otrzymywania użytkowych ilości tych substancji. Obecnie HPLC jest najistotniejszą metodą oczyszczania...
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A targeted mass spectrometry immunoassay to quantify osteopontin in fresh-frozen breast tumors and adjacent normal breast tissues
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Activity-based protein profiling guided identification of urine proteinase 3 activity in subclinical rejection after renal transplantation
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Badanie procederu fałszowania mięsa – poważny problem analityczny
PublicationFałszowanie żywności, w tym produktów mięsnych, stanowi problem ogólnoświatowy. Analitycy ze zdwojonym wysiłkiem pracują nad metodami badawczymi, które umożliwią zarówno weryfikację jakości jak i określenie autentyczności danego produktu żywnościowego. Dotychczas, w celu określenia autentyczności mięsa wykorzystywano najczęściej techniki oparte na elektroforezie żelowej oraz testy immunoenzymatyczne. Równie popularne, stały się...
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Isolation of Citrus lemon extracellular vesicles: Development and process control using capillary electrophoresis
PublicationA new and scalable method for the isolation of extracellular vesicles (EV) from Citrus lemon juice samples was developed. The methodology included preliminary preconcentration of the sample using ultrafiltration (UF) followed by size-exclusion chromatography (SEC) purification and final preconcentration of the eluates. Transmission electron microscopy and proteomic analysis showed that isolates contained exosome-like vesicles, exocyst-positive...
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Toxoplasma gondii Recombinant Antigens in the Serodiagnosis of Toxoplasmosis in Domestic and Farm Animals
PublicationToxoplasmosis is caused by an intracellular protozoan, Toxoplasma gondii, and is a parasitic disease that occurs in all warm-blooded animals, including humans. Toxoplasmosis is one of the most common parasitic diseases of animals and results in reproductive losses. Toxoplasmosis in humans is usually caused by eating raw or undercooked meat or consuming dairy products containing the parasite. Diagnosis of toxoplasmosis is currently...
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Lipidomika – strategie analityczne i zastosowania
PublicationBioanalityka, to interdyscyplinarna dziedzina wiedzy, która stanowi szybko rozwijający się obecnie dział chemii analitycznej. Bioanaliza zaczyna odgrywać kluczową rolę w szybko rozwijających się dziedzinach współczesnej bionauki w ramach genomiki, proteomiki, metabolomiki, lipidomiki i innych. Umiejętność doboru odpowiednich metod i narzędzi, w zależności od rodzaju podejmowanego problemu, jest niezwykle ważne i często decyduje...
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More Than just Antioxidants: Redox-Active Components and Mechanisms Shaping Redox Signalling Network
PublicationsettingsOrder Article Reprints This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessReview More Than just Antioxidants: Redox-Active Components and Mechanisms Shaping Redox Signalling Network by Monika Kuczyńska,Patrycja Jakubek andAgnieszka Bartoszek *ORCID Faculty of Chemistry, Gdańsk University of Technology, 80-233 Gdańsk, Poland * Author to whom correspondence should...
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Insight into the oligomeric structure of PORA from A. thaliana
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Molecular profiles of thyroid cancer subtypes: Classification based on features of tissue revealed by mass spectrometry imaging
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Modification of quaternary structure of Candida albicans GlcN-6-P synthase and its desensitization to inhibition by UDP-GlcNAc by site-directed mutagenesis
PublicationSite-directed mutagenesis of the CaGFA1 gene encoding glucosamine-6-phosphate synthase from Candida albicans was performed. Desensitization of the enzyme to inhibition by UDPGlcNAc was achieved upon T487I and H492F substitutions at the UDP-GlcNAc binding site, exchange of D524, S525 and S527 for Ala at the dimer:dimer interface and construction of the tail-lock array (L434R and L460A) at the C-tail region. The first two sets if...
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Application of high pressure laser flash photolysis in studies on selected hemoprotein reactions
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Intra- and intersubunit changes accompanying thermal activation of the HtrA2(Omi) protease homotrimer
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The role of the LB structural loop and its interactions with the PDZ domain of the human HtrA3 protease
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Rat cathepsin K: Enzymatic specificity and regulation of its collagenolytic activity
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