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Search results for: ANTIVIRAL AGENTS
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Rafał Leszczyna dr hab. inż.
PeopleDr hab. Rafal Leszczyna is an associate professor at Gdansk University of Technology, Faculty of Management and Economics. He holds the M.Sc. degrees of Computer Science and Business Management. In December, 2006 he earned a Ph.D. in Computer Science, specialisation - Computer Security at the Faculty of Electronics, Telecommunications and Informatics of Gdansk University of Technology. Between 2004 and 2008 he worked in the European...
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Isolation of Bacteriocin-producing Staphylococcus spp. Strains from Human Skin Wounds, Soft Tissue Infections and Bovine Mastitis
PublicationA collection of 206 Staphylococcus spp. isolates was investigated for their ability to produce compounds exhibiting antistaphylococcal activity. This group included Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus xylosus strains recovered from bovine mastitis (n = 158) and human skin wounds and soft tissues infections (n = 48). Production of substances with antimicrobial activity was observed in six strains. Five...
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Journal of Policy Research in Tourism Leisure and Events
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Effects of three-month feeding high-fat diets with different fatty acid composition on kidney histology and expression of genes related to cellular stress and water-electrolyte homeostasis in mice
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Use of Escherichia coli Nissle 1917 producing recombinant colicins for treatment of IBD patients
PublicationPatients with Crohn’s Disease and ulcerative colitis infected with Adherent-Invasive Escherichia coli strains constitute the largest group among Inflammatory Bowel Disease subjects, when taking into account all known etiological agents of the disease. A possible link between these pathogenic bacteria and inflammation process has gained the confidence in recently published papers. Observed enteric neuroglial cells apoptosis and...
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Katarzyna Tubielewicz dr
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Handelingen der Maatschappij voor Geschiedenis en Oudheidkunde te Gent
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Vivarium. An International Journal for the Philosophy and Intellectual Life of the Middle Ages and Renaissance
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Identification and cloning of C. albicans SC5314 genes encoding L-methionine biosynthetic pathway enzymes.
Open Research DataEnzymes of fungal L-methionine biosynthetic pathway: homoserine O-acetyltransferase (Met2p), O-acetylhomoserine sulfhydrylase (Met15p) and cystathionine-γ-synthase (Str2p) could be exploited as molecular targets for antifungal chemotherapy. The goal of the study was to identify and clone genes encoding mentioned above enzymes. MET2, MET15 and STR2 genes...
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Mechanism of reaction of RNA-dependent RNA polymerase from SARS-CoV-2
PublicationWe combine molecular dynamics, statistical mechanics, and hybrid quantum mechanics/molecular mechanics simulations to describe mechanistically the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA-dependent RNA polymerase (RdRp). Our study analyzes the binding mode of both natural triphosphate substrates as well as remdesivir triphosphate (the active form of drug), which is bound preferentially over ATP by RdRp while...
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Harmony Search for Self-configuration of Fault–Tolerant and Intelligent Grids
PublicationIn this paper, harmony search algorithms have been proposed to self-configuration of fault-tolerant grids for big data processing. Self-configuration of computer grids lies in the fact that new computer nodes are automatically configured by software agents and then integrated into the grid. A base node works due to several configuration parameters that define some aspects of data communications and energy power consumption. We...
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Particle swarm optimization algorithms for autonomous robots with deterministic leaders using space filling movements
PublicationIn this work the swarm behavior principles of Craig W. Reynolds are combined with deterministic traits. This is done by using leaders with motions based on space filling curves like Peano and Hilbert. Our goal is to evaluate how the swarm of agents works with this approach, supposing the entire swarm will better explore the entire space. Therefore, we examine different combinations of Peano and Hilbert with the already known swarm...
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Antimicrobial Activity of Honey
PublicationHoney has had a valued place in traditional medicine for centuries. It was used to overcome liver, cardiovascular and gastrointestinal problems and for treatment of some types of infectious disease. Particularly, good results were achieved in the case of application of this product for therapy of infected, difficult to heal wounds. The high health-promoting properties of honey have been recently confirmed in many research investigations....
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GC Chromatograms for isomerization of alpha-pinene
Open Research DataData contain results of the catalytic tests for the isomerization of alpha-pinene for the Ti3C2Tx MXenes produced via acidic etching aluminum from MAX Phase (Ti3C2-Al-Ti3C2-Al-Ti3C2) using different etching agents, HF/HCl and HF/H2SO4 with different weight ratios (1:3, 1:4, and 1:5). The samples were labeled as MXene HF/HCl X:Y and MXene HF/H2SO4 X:Y,...
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Expression patterns of candidate genes for the Lr46/Yr29 “slow rust” locus in common wheat (Triticum aestivum L.) and associated miRNAs inform of the gene conferring the Puccinia triticina resistance trait
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Drawing maps with advice
PublicationW pracy podejmujemy temat konstrukcji algorytmu dla agenta, który zostaje umieszczony w dowolnym wierzchołku grafu (wierzchołki są nierozróżnialne, krawędzie mają etykiety portów), po czym realizuje algorytm zmierzający do znalezienia drzewa spinającego grafu lub izomorficznej kopii grafu. Dla obu problemów podajemy asymptotycznie dokładne lub prawie dokładne oszacowania na ilość bitów dodatkowej informacji, którą agent musi otrzymać...
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The II phase metabolism of endogenous and exogenous compounds, including antitumor chemotherapeutics
PublicationThe II phase metabolism, it is a set of metabolism and excretion pathways of endogenous as well as exogenous compounds including xenobiotics. UDP-glucuronyltransferases (UGTs; EC 2.4.1.17) are the most crucial representatives of II phase enzymes, which are responsible for the transformation of bilirubine and bile acids, steroids and thyroid hormones and lipids. Exogenous compounds, including drugs, carcinogens, environmental pollutants...
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Molecular typing of clinical isolates of Escherichia coli by a new PCR MP method
PublicationTypowanie epidemiologiczne bakterii jest rutynową procedurą stosowaną w badaniach zakażeń szpitalnych i wymaga stosowania odpowiednich metod o wysokim potencjale różnicującym. Przedstawiliśmy możliwości nowej techniki PCR MP w różnicowaniu szczepów E. coli. Rezultaty zostały porównane z wynikami uzyskanymi metodą PFGE.
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International Conference on Principles of Practice in Multi-Agent Systems
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Przechwytywanie obiektów poruszających się z ograniczoną prędkością
PublicationKrawędziowa liczba przeszukiwawcza grafu informuje nas ilu mobilnych agentów, przykładowo jednostek policji, jest niezbędnych do przechwycenia poruszającego się z dowolnie dużą prędkością uciekiniera w danym grafie. Podczas praktycznych zastosowań modelu w systemach bezpieczeństwa rzadko jednak spotyka się jednostki poruszające się z nieograniczoną prędkością. W pracy tej pokazujemy, że agenci mogą wykorzystać fakt ograniczonej...
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"SDG # pawilon tematyczny"-wystawa projektów studenckich
PublicationZgromadzenie Ogólne Organizacji Narodów Zjednoczonych w 2015 roku przyjęło Rezolucję 70/1 “Przekształcamy nasz świat: Agenda na rzecz zrównoważonego rozwoju 2030”. Jest to plan działań na rzecz ludzi, planety i dobrobytu oraz wzmocnienia powszechnego pokoju w warunkach większej wolności. Jest wdrażany przez wszystkie kraje w ramach współpracy partnerskiej. Agenda 2030 wyrażona jest poprzez 17 Celów Zrównoważonego Rozwoju (SDG...
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Designing with Green and Blue – Climate Adaption Proposals for Lowland Areas of Gdańsk
PublicationThe paper gives insight into issues explored within the framework of the SOS Climate Waterfront workshop that took place in Gdańsk in June 2019. The aim of the study was to propose solutions that will decrease the number of flooding events and span the gap between flood prevention strategies and the provision of other benefits such as ecological, urban, cultural and social. Historical cartography enquiries and research by the design...
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TGA data of MXenes catalysts
Open Research DataData contain results from TGA measurement of the Ti3C2Tx MXenes produced via acidic etching aluminum from MAX Phase (Ti3C2-Al-Ti3C2-Al-Ti3C2) using different etching agents, HF/HCl and HF/H2SO4 with different weight ratios (1:3, 1:4, and 1:5). The samples were labeled as MXene HF/HCl X:Y and MXene HF/H2SO4 X:Y, where X:Y means the acids weight ratios. ...
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Adsorption and desorption of N2 measurement of MXenes catalysts
Open Research DataData contain results from adsorption and desorption of N2 measurement of the Ti3C2Tx MXenes produced via acidic etching aluminum from MAX Phase (Ti3C2-Al-Ti3C2-Al-Ti3C2) using different etching agents, HF/HCl and HF/H2SO4 with different weight ratios (1:3, 1:4, and 1:5). The samples were labeled as MXene HF/HCl X:Y and MXene HF/H2SO4 X:Y, where X:Y...
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Lower rim substituted tert-butylcalix[4]arenes (II). Complexing ability of5,11,17,23-tetra-tert-butyl-25,26,27,28-tetrakis-O-(piperidinylcarbonyl)me- thylenecalix[4]arene. The crystal structures of the ligand and its sodium complex
PublicationSyntezowano kompleksy wymienionego w tytule liganda z chlorkiem sodu i azotanami itru(III), lantanu(III), samaru(III) i gadolinu(III) w reakcji liganda i odpowiedniej soli, które charakteryzowano za pomocą widm IR, UV-vis,1H NMR, FAB-MS, a także za pomocą analizy elementarnej. W reakcji wymiany z kompleksu z sodem otrzymywano kompleksy z lantanowcami. Określono strukturę krystaliczną wolnego liganda i jego kompleksu z sodem za...
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Green sample preparation techniques for chromatographic determination of small organic compounds
PublicationAccurate monitoring of the state of the environment requires the introduction of additional isolation and/or preconcentration step prior to the chromatographic determination. In this work the information about novel methodological and instrumental solutions in relation to different variants of microextraction techniques are presented. Attention is focused on analytical procedure and suitable analytical tools for extraction of the...
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Big Data and the Internet of Things in Edge Computing for Smart City
PublicationRequests expressing collective human expectations and outcomes from city service tasks can be partially satisfied by processing Big Data provided to a city cloud via the Internet of Things. To improve the efficiency of the city clouds an edge computing has been introduced regarding Big Data mining. This intelligent and efficient distributed system can be developed for citizens that are supposed to be informed and educated by the...
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Modifications at the C(5) position of pyrimidine nucleosides
PublicationThis review summarizes the state of knowledge on the chemical methods of C(5)-modifications of uridine and cytidine derivatives and may serve as a useful tool for synthetic chemists to choose an appropriate reaction protocol. The synthesis of 5-substituted uracil derivatives is gaining an increasing interest because of their possible applications in medicine and pharmacy. Modifications at the C(5) position of pyrimidine nucleosides...
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Therapeutic Potential of Carnosine and Its Derivatives in the Treatment of Human Diseases
PublicationDespite significant progress in the pathogenesis, diagnosis, treatment, and prevention of cancer and neurodegenerative diseases, their occurrence and mortality are still high around theworld. The resistance of cancer cells to the drugs remains a significant problem in oncology today,while in the case of neuro-degenerative diseases, therapies reversing the process are still yet to be found. Furthermore, it is important to seek new...
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One More Step Towards a Circular Economy for Thermal Insulation Materials—Development of Composites Highly Filled with Waste Polyurethane (PU) Foam for Potential Use in the Building Industry
PublicationThe rapid development of the building sector has created increased demand for novel materials and technologies, while on the other hand resulting in the generation of a severe amount of waste materials. Among these are polyurethane (PU) foams, which are commonly applied as thermal insulation materials. Their management is a serious industrial problem, due to, for example, their complex chemical composition. Although some chemical...
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The Impact of Long-Time Chemical Bonds in Mineral-Cement-Emulsion Mixtures on Stiffness Modulus
PublicationDeep cold in-place recycling is the most popular method of reuse of existing old and deteriorated asphalt layers of road pavements. In Poland, in most cases, the Mineral-Cement-Emulsion mixture technology is used, but there are also applications combining foamed bitumen and cement. Mineral-Cement-Emulsion mixtures contain two different binding agents – cement as well as asphalt from the asphalt emulsion. Asphalt creates asphalt...
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Retrofitted vibro-pressed pavement bricks and their impregnation in modern architecture.
PublicationRecent construction projects require new properties of concrete building materials. The paper describes the technological methods of retrofitting of vibro-pressed concrete pavement brick and shows the results of improving physical properties of concrete by application of different impregnation agents.
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XRD patterns of MXenes catalysts
Open Research DataData contain results from XRD measurements of the Ti3C2Tx MXenes produced via acidic etching aluminum from MAX Phase (Ti3C2-Al-Ti3C2-Al-Ti3C2) using different etching agents, HF/HCl and HF/H2SO4 with different weight ratios (1:3, 1:4, and 1:5). The samples were labeled as MXene HF/HCl X:Y and MXene HF/H2SO4 X:Y, where X:Y means the acids weight ratios....
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Raman spectra of MXenes catalysts
Open Research DataData contain results from Raman spectroscopy of the Ti3C2Tx MXenes produced via acidic etching aluminum from MAX Phase (Ti3C2-Al-Ti3C2-Al-Ti3C2) using different etching agents, HF/HCl and HF/H2SO4 with different weight ratios (1:3, 1:4, and 1:5). The samples were labeled as MXene HF/HCl X:Y and MXene HF/H2SO4 X:Y, where X:Y means the acids weight ratios. ...
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SEM images of MXene catalysts
Open Research DataData contain results SEM measurements of the Ti3C2Tx MXenes produced via acidic etching aluminum from MAX Phase (Ti3C2-Al-Ti3C2-Al-Ti3C2) using different etching agents, HF/HCl and HF/H2SO4 with different weight ratios (1:3, 1:4, and 1:5). The samples were labeled as MXene HF/HCl X:Y and MXene HF/H2SO4 X:Y, where X:Y means the acids weight ratios. MAX...
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Synthetic strategies in construction of organic low molecular-weight carrier-drug conjugates
PublicationInefficient transportation of polar metabolic inhibitors through cell membranes of eukaryotic and prokaryotic cells precludes their direct use as drug candidates in chemotherapy. One of the possible solutions to this problem is application of the ‘Trojan horse’ strategy, i.e. conjugation of an active substance with a molecular carrier of organic or inorganic nature, facilitating membrane penetration. In this work, the synthetic...
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Solid Phase Micro-Extraction, a Versatile and Handy Tool in Environmental Trace Organic Analysis, Gets a New Class of Coatings, Polymeric Ionic Liquids
PublicationSolid phase microextraction (SPME) fundamentals, characteristics and application are described. The special stress is put on characteristics of sorbents used as SPME fiber coatings. Description of commercially available fibers and the present-day trends in development of new sorbents for SPME are given. Discussion is focused on possibility of application of ionic liquids (IL) and polymeric ionic liquids (PIL) as SPME fiber coatings....
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Catalysts for advanced oxidation processes: Deep eutectic solvents-assisted synthesis – A review
PublicationNew catalyst synthesis techniques, including green materials, are extensively studied for heterogeneous photocatalytic advanced oxidation processes (AOPs) on spotlight of sustainable development. Deep eutectic solvents (DESs) started to be used in this field as environmentally friendly alternative to ionic liquids (ILs). During the catalyst synthesis, DESs can act as stabilizers, capping agents, structure directing agents, templates,...
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Complex modulus of Cement Bitumen Treated Material Mixture (28 days of curing at 20C)
Open Research DataDataset presents data of complex modulus determined for cold recycled mixture – cement bitumen treated material mixture with 3 combinations of binding agents: 2% cement, 6% emulsion (C2E6), 6% cement, 6% emulsion (C6E6), 6% cement, 2% emulsion (C6E2). Mixture was designed according to Polish requirements for the base course of pavement. Mixture contains...
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PCR and real-time PCR assays to detect fungi of Alternaria alternata species
PublicationFungi of the Alternaria genus are mostly associated with allergic diseases. However, with a growing number of immunocompromised patients, these fungi, with A. alternata being the most prevalent one, are increasingly recognized as etiological agents of infections (phaeohyphomycoses) in humans. Nowadays, identification of Alternaria spp. requires their pure culture and is solely based on morphological criteria. Clinically, Alternaria...
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Optical method supported by machine learning for dynamics of C‐reactive protein concentrations changes detection in biological matrix samples
PublicationIn this article we present the novel spectroscopy method supported with machine learning for real-time detection of infectious agents in wastewater. In the case of infectious diseases, wastewater monitoring can be used to detect the presence of inflammation biomarkers, such as the proposed C-reactive protein, for monitoring inflammatory conditions and mass screening during epidemics for early detection in communities of concern,...
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Discussion on “Coupled effective stress analysis of insertion problems in geotechnics with the Particle Finite Element Method” by L. Monforte, M. Arroyo, J.M. Carbonell, and A. Gens
PublicationAddressed here is the Particle Finite Element Method (PFEM) modelling of undrained CPTu penetration with regard to a reference analytical solution based on the Spherical Cavity Expansion Method (SCEM). Also discussed is the choice of the soil model and its parameters. The effect of cone interface friction on CPTu simulation is analyzed in a series of penetration tests using Arbitrary Lagrangian-Eulerian (ALE) and Updated Lagrangian...
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Complex modulus of Cement Bitumen Treated Material Mixture C3E4 laboratory mixed/laboratory compacted (7-365 days of curing at 20C)
Open Research DataDataset presents data of complex modulus determined for cold recycled mixture – cement bitumen treated material mixture with following binding agents: 3% cement, 4% emulsion (C3E4). Mixture was designed according to Polish requirements for the base course of pavement. Mixture was mixed in laboratory conditions on the basis of materials obtained from...
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Complex modulus of Cement Bitumen Treated Material Mixture C3E4 field mixed/laboratory compacted (7-365 days of curing at 20C)
Open Research DataDataset presents data of complex modulus determined for cold recycled mixture – cement bitumen treated material mixture with following binding agents: 3% cement, 4% emulsion (C3E4). Mixture was designed according to Polish requirements for the base course of pavement. Mixture was mixed in the field conditions and later compacted in laboratory. Mixture...
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Deformation Sweep Test of Cement Bitumen Treated Material Mixture C3E5.5 (field obtained material; over 28 days of curing at 20C)
Open Research DataDataset presents data of results of deformation sweep test determined for cold recycled mixture – cement bitumen treated material mixture with following binding agents: 3% cement and 5.5% emulsion (C3E5.5). Mixture was designed according to Polish requirements for the base course of pavement. Mixture contains 60% of RAP material. Specimen size: f=100...
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Deformation Sweep Test of Cement Bitumen Treated Material Mixture C3E5.5 (field cores; field curing)
Open Research DataDataset presents data of results of deformation sweep test determined for cold recycled mixture – cement bitumen treated material mixture with following binding agents: 3% cement and 5.5% emulsion (C3E5.5). Mixture was designed according to Polish requirements for the base course of pavement. Mixture contains 60% of RAP material. Specimen size: f=100...
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Cytotoxicity of QDgreen-holo-Tf-C-2028 and QDred-holo-Tf-C-2028 aginst H460 cancer cells_method of synthesis 2
Open Research DataThis study presents absorbance of formazan product (converted from MTT) which corresponds the cytotoxicity of QDgreen-holo-Tf-C-2028 and QDred-holo-Tf-C-2028 aginst H460 cancer cells (method of synthesis 2). Holo-Tf (transferrin) was used as a linker between quantum dots (QDs) and compound (C-2028).
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Cytotoxicity of QDgreen-holo-Tf-C-2028 and QDred-holo-Tf-C-2028 aginst H460 cancer cells_method of synthesis 3
Open Research DataThis study presents absorbance of formazan product (converted from MTT) which corresponds the cytotoxicity of QDgreen-holo-Tf-C-2028 and QDred-holo-Tf-C-2028 aginst H460 cancer cells (method of synthesis 3). Holo-Tf (transferrin) was used as a linker between quantum dots (QDs) and compound (C-2028).
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Lucyna Nyka prof. dr hab. inż. arch.
PeopleLucyna Nyka (Ph.D., D.Sc., Prof.) is a Professor at the Faculty of Architecture, Gdańsk University of Technology, in 2008-2016 a Vice-Dean for Research, and since 2016 – Dean of the Faculty of Architecture. Her research interests focus on issues concerning water-related architecture and urban landscapes. She is the author and co-author of many projects focused on urban renewal. She was an author of the EU-founded (Audiovisual...
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Metabolic transformation of antitumor acridinone C-1305 but not C-1311 via selective cellular expression of UGT1A10 increases cytotoxic response: implications for clinical use.
PublicationThe acridinone derivates C-1305 and C-1311 are promising antitumor agents with high activity against several experimental cellular and tumor models and which are under evaluation in pre-clinical and early phase clinical trials. Recent evidence from our laboratories has indicated that both compounds were conjugated by several UGT isoforms with the most active being extrahepatic UGT1A10. The present studies were designed to test...