Search results for: metabolity
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Folate/homocysteine metabolism and lung cancer risk among smokers
PublicationBackground: Folate and homocysteine are involved in DNA synthesis and methylation processes, which are deregulated during carcinogenesis. Objectives: The aim of this study was to assess the relationship between folate/homocysteine concentrations, the functional polymorphisms of folate/homocysteine genes and lung cancer risk among cigarette smokers. Study design: The study included 132 lung cancer patients and 396 controls from...
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Characterization of metabolites in different kiwifruit varieties by NMR and fluorescence spectroscopy
PublicationIt is known from our previous studies that kiwifruits, which are used in common human diet, have preventive properties of coronary artery disease. This study describes a combination of 1H NMR spectroscopy, multivariate data analyses and fluorescence measurements in differentiating of some kiwifruit varieties, their quenching and antioxidant properties. A total of 41 metabolites were identified by comparing with literature data...
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Microbiota-derived metabolites in colorectal cancer patients in preoperative period
PublicationShort-chain fat-ty acids (SCFAs) are microbial derived metabo-lites, which have multiple beneficial properties. The amount of SCFAs depends on several fac-tors, such as age, diet (mainly intake of dietary fiber), and overall health condition. The normal proportion between SCFAs is 3:1:1 for acetate, proprionate and butyrate, respectively. In col-orectal cancer (CRC) patients, microbiota alter-ations have been shown. Consequently,...
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Altered levels of nucleoside metabolite profiles in urogenital tract cancer measured by capillary electrophoresis
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Paraffin-Embedded Tissue as a Novel Matrix in Metabolomics Study: Optimization of Metabolite Extraction Method
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Antibacterial activity of the secondary metabolites from in vitro cultures of Drosera aliciae
PublicationRośliny owadożerne (D. aliciae) metabolity wtórne farmakologicznie czynne substancje. Na wzrost akumulacji tychże substancji w tkankach roślin owadożernych ma wpływ dodatek elicytora. Końcowego oznaczenia zawartości metabolitów w ekstraktach roślinnych dokonano techniką chromatografii cieczowej.
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Induction of secondary metabolite production in transformated callus of Ammi majus L. grown after electromagnetic treatment of culture medium
PublicationW pracy przedstawiono wyniki badań, których celem było zbadanie wpływu elicytacji przy użyciu ADR-4, na produkcję metabolitów wtórnych. Elicytacja ADR-4 zwiększyła 2-krotnie zawartość bergaptenu. Porównano również efektywność 3 technik ekstrakcyjnych stosowanych do izolacji feuranokumaryn, kumaryn i ich glikozydów z kalusa A.majus. Ekstrakcja przy użyciu techniki ASE okazała się najbardziej efektywna.
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Porównanie efektywności wybranych technik ekstrakcji/ługowania metabolitów wtórnych z suchego materiału roślin owadożernych z hodowli in vitro = Acomparison of effciency of secondary metabolites extraction/leaching techniques from carnivorous plants dry material from in vitro culture
PublicationW roślinach owadożernych za efekt terapeutyczny odpowiadają głównie pochodne 1,4-naftochinonu (juglon), oraz flawonoidy. Interesujące właściwości tych związków oraz możliwość synergicznego działania wielu innych metabolitów na efekt terapeutyczny, podjęto pracę przygotowania technologii efektywnego wyodrębniania metabolitów. W tej publikacji porównano efektywności technik ekstrakcji/ługowania. Jako materiał badany posłużyły wysuszone...
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Electrochemistry meets enzymes: Investigation of the biotransformation pathway of C-1311 based on electrochemical simulation in comparison to in vitro methods.
PublicationThe knowledge of the metabolic pathways and the biotransformation of new drugs is one of the major challenges in pharmaceutical research. It is crucial for elucidation of degradation routes of the new biologically active compounds, especially in the area of possible toxicity. Conventional in vitro drug metabolism studies are based on incubating drug candidate with e.g. hepatocytes or, most importantly, liver cell microsomes and...
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Significance of selected inflammatory factors in metabolic disorders in association with psoriasis
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The metabolic syndrome in hypertension: European society of hypertension position statement
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Metabolic profiling of pteridines for determination of potential biomarkers in cancer diseases
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Electronic Cigarette Use and Metabolic Syndrome Development: A Critical Review
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Carbon assimilation profiles of mucoralean fungi show their metabolic versatility
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Flavonoid biosynthetic pathways in plants: Versatile targets for metabolic engineering
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The usefulness of fluorescence in detecting ischemia during bariatric and metabolic surgery
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A numerical scale to assess the outcomes of metabolic/bariatric surgery (NOMS)
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IFI16 Impacts Metabolic Reprogramming during Human Cytomegalovirus Infection
PublicationCellular lipid metabolism plays a pivotal role in human cytomegalovirus (HCMV) infection, as increased lipogenesis in HCMV-infected cells favors the envelopment of newly synthesized viral particles. As all cells are equipped with restriction factors (RFs) able to exert a protective effect against invading pathogens, we asked whether a similar defense mechanism would also be in place to preserve the metabolic compartment from HCMV...
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Bisphenol A analogues and metabolic syndrome in women with polycystic ovary syndrome
PublicationBisphenols (BPs) have become a chemical group of special interest due to their ability to interfere with the endocrine system and their ubiquitous presence in the environment. As some of them possess mild estrogenic and anti-androgenic effects, they might be associated with the diagnosis of polycystic ovary syndrome (PCOS). Acting on multiple tissues, BPs exposure may lead to metabolic derangements characteristic for metabolic...
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Searching for the primary metabolic alterations of polycystic ovary syndrome by application of the untargeted metabolomics approach
PublicationDespite a large number of studies, the pathogenesis of polycystic ovary syndrome (PCOS) still remains unexplained. In light of ambiguous observations reported in metabolomics, there is a need to carry out studies focusing on confirming the discriminating power of the proposed metabolomics biomarkers. Our research aimed to perform a validation study of metabolites detected in our previous study from serum samples, on the new set...
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Determination of bromhexine and its metabolites in equine serum samples by liquid chromatography – Tandem mass spectrometry: Applicability to the elimination study after single oral dose
PublicationBromhexine (BH), expectorant used in the treatment of respiratory disorders associated with viscid or excessive mucus, is not permitted for use in the competing horse by many authorities in horseracing and Olympic disciplines. Metabolic studies are of the great importance in anti-doping field because they allow for updating the selection of the most appropriate markers for prohibited substances, such as metabolites present at higher...
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International Journal of Secondary Metabolite
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DIABETES OBESITY & METABOLISM
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Journal of Endocrinology and Metabolism
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Nutritional Therapy & Metabolism
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Journal of Nutrition and Metabolism
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Archives of Endocrinology Metabolism
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Cardiovascular Endocrinology & Metabolism
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Diabetes & Metabolism Journal
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Drug Metabolism and Pharmacokinetics
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DIABETES NUTRITION & METABOLISM
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Journal of Diabetes & Metabolism
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Drug Metabolism Letters
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Human Nutrition and Metabolism
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MOLECULAR GENETICS AND METABOLISM
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METABOLISM-CLINICAL AND EXPERIMENTAL
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Obesity and Metabolism-Milan
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Endocrinology, Diabetes and Metabolism
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Journal of Bone Metabolism
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Critical approach to PLE technique application in the analysis of secondary metabolites in plants
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Vitamin D Metabolism Gene Polymorphisms and Their Associated Disorders: A Literature Review
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Activities of genes controlling sphingolipid metabolism in human fibroblasts treated with flavonoids
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Renal Regulation of Calcium-Phosphate Metabolism in Single- and Twin Pregnant Goats
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Central carbon metabolism influences fidelity of DNA replication in Escherichia coli
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Disposition of Drugs of Abuse and Their Metabolites in Wastewater as a Method of the Estimation of Drug Consumption
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Modulation of expression of genes involved in glycosaminoglycan metabolism and lysosome biogenesis by flavonoids
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Ascorbate and glutathione metabolism in embryo axes and cotyledons of germinating lupine seeds
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Evaluation of bioconcentration and metabolism of diclofenac in mussels Mytilus trossulus - laboratory study
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Lactose and β-Glucosides Metabolism and Its Regulation in Lactococcus lactis: A Review
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Bioprospecting endophytic fungi for bioactive metabolites and use of irradiation to improve their bioactivities
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