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Search results for: John Botsack
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Impacts of salvage logging on biodiversity: A meta-analysis
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Targeting BTK with Ibrutinib in Relapsed or Refractory Mantle-Cell Lymphoma
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Expertise: No Longer a Sine Qua Non for Guideline Authors?
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Sequence-dependent structural properties of B-DNA: what have we learned in 40 years?
PublicationThe structure of B-DNA, the physiological form of the DNA molecule, has been a central topic in biology, chemistry and physics. Far from uniform and rigid, the double helix was revealed as a flexible and structurally polymorphic molecule. Conformational changes that lead to local and global changes in the helix geometry are mediated by a complex choreography of base and backbone rearrangements affecting the ability of the B-DNA...
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Splice variants of mitofusin 2 shape the endoplasmic reticulum and tether it to mitochondria
PublicationIn eukaryotic cells, different organelles interact at membrane contact sites stabilized by tethers. Mitochondrial mitofusin 2 (MFN2) acts as a membrane tether that interacts with an unknown partner on the endoplasmic reticulum (ER). In this work, we identified the MFN2 splice variant ERMIT2 as the ER tethering partner of MFN2. Splicing of MFN2 produced ERMIT2 and ERMIN2, two ER-specific variants. ERMIN2 regulated ER morphology,...
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Silver nanoparticles induce premutagenic DNA oxidation that can be prevented by phytochemicals from Gentiana asclepiadea
PublicationAmong nanomaterials, silver nanoparticles (AgNPs) have the broadest and most commercial applications due to their antibacterial properties, highlighting the need for exploring their potential toxicity and underlying mechanisms of action. Our main aim was to investigate whether AgNPs exert toxicity by inducing oxidative damage to DNA in human kidney HEK 293 cells. In addition, we tested whether this damage could be counteracted...
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Reply
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Expertise
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Direct brain stimulation modulates encoding states and memory performance in humans
PublicationPeople often forget information because they fail to effectively encode it. Here, we test the hypothesis that targeted electrical stimulation can modulate neural encoding states and subsequent memory outcomes. Using recordings from neurosurgical epilepsy patients with intracranially implanted electrodes, we trained multivariate classifiers to discriminate spectral activity during learning that predicted remembering from forgetting,...
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Progress in upscalingMiscanthusbiomass production for the European bio-economy with seed-based hybrids
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Consequences of cathepsin C inactivation for membrane exposure of proteinase 3, the target antigen in autoimmune vasculitis
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Evaluation of the BNT162b2 Covid-19 Vaccine in Children 5 to 11 Years of Age
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A standardised static in vitro digestion method suitable for food – an international consensus
PublicationSimulated gastro-intestinal digestion is widely employed in many fields of food and nutritional sciences, as conducting human trials are often costly, resource intensive, and ethically disputable. As a consequence, in vitro alternatives that determine endpoints such as the bioaccessibility of nutrients and non-nutrients or the digestibility of macronutrients (e.g. lipids, proteins and carbohydrates) are used for screening and building...
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Distinct clinical phenotypes in paediatric cancer patients with sepsis are associated with different outcomes—an international multicentre retrospective study
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Country‐level and individual‐level predictors of men's support for gender equality in 42 countries
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Belief in a zero-sum game and subjective well-being across 35 countries
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Modeling SARS‐CoV‐2 proteins in the CASP‐commons experiment
PublicationCritical Assessment of Structure Prediction (CASP) is an organization aimed at advancing the state of the art in computing protein structure from sequence. In the spring of 2020, CASP launched a community project to compute the structures of the most structurally challenging proteins coded for in the SARS-CoV-2 genome. Forty-seven research groups submitted over 3000 three-dimensional models and 700 sets of accuracy estimates on...
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INFOGEST static in vitro simulation of gastrointestinal food digestion
PublicationDeveloping a mechanistic understanding of the impact of food structure and composition on human health has increasingly involved simulating digestion in the upper gastrointestinal tract. These simulations have used a wide range of different conditions that often have very little physiological relevance, and this impedes the meaningful comparison of results. The standardized protocol presented here is based on an international consensus...
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Zdolni z Pomorza 2020/21 - O kompleksach słów kilka…
e-Learning CoursesKompleksy towarzyszą każdemu z nas – nawet osobom najbardziej pogodnym. Mamy je we krwi. Dzięki związkom kompleksowym życie (jakie znamy) jest w ogóle możliwe… Związki kompleksowe to połączenia metali i ich jonów z ligandami (którymi mogą być organiczne lub nieorganiczne cząsteczki lub jony) poprzez wiązania koordynacyjne. Wiązania takie powstają gdy wolna para elektronowa liganda jest uwspólniana z centrum metalicznym – atom metalu...
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Blood pressure and low-density lipoprotein-cholesterol lowering for prevention of strokes and cognitive decline
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Blood pressure and LDL-cholesterol targets for prevention of recurrent strokes and cognitive decline in the hypertensive patient
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Continuation of the ESH-CHL-SHOT trial after publication of the SPRINT
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Going to extremes – a metagenomic journey into the dark matter of life
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Minimum Information about T Regulatory Cells: A Step toward Reproducibility and Standardization
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Theory of Architectural Design I. Introduction 2022
e-Learning CoursesLectures are held online on Wednesdays from 19:15 to 20:00 Theory of Architectural Design I 1 https://teams.microsoft.com/l/meetup-join/19%3ameeting_YWVkZWJiZWUtYzY2Yy00NzNiLThlMzctNWY3Y2U2YjgxODc4%40thread.v2/0?context=%7b%22Tid%22%3a%2286760356-0022-486f-b793-a2d470bba5a5%22%2c%22Oid%22%3a%22ca4e7f4e-c85d-4f86-914f-456ee1702ebe%22%7d Our course aims to teach you how to design architecture. The process of...
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Introduction to a Culturally Sensitive Measure of Well-Being: Combining Life Satisfaction and Interdependent Happiness Across 49 Different Cultures
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Happiness Maximization Is a WEIRD Way of Living
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13th International Conference on Conservative Management of Spinal Deformities and First Joint Meeting of the International Research Society on Spinal Deformities and the Society on Scoliosis Orthopaedic and Rehabilitation Treatment – SOSORT-IRSSD 2016 meeting
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Gendered Self-Views Across 62 Countries: A Test of Competing Models
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Psychometric Properties and Correlates of Precarious Manhood Beliefs in 62 Nations
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Long-term safety and efficacy of benralizumab in patients with severe, uncontrolled asthma: 1-year results from the BORA phase 3 extension trial
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Gender Gap in Parental Leave Intentions: Evidence from 37 Countries
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18th European Symposium on Radiopharmacy and Radiopharmaceuticals
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Architektura a dekonstrukcja. Przypadek Petera Eisenmana i Bernarda Tschumiego
PublicationArchitecture and Deconstruction Case of Peter Eisenman and Bernard Tschumi Introduction Towards deconstruction in architecture Intensive relations between philosophical deconstruction and architecture, which were present in the late 1980s and early 1990s, belong to the past and therefore may be described from a greater than...
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Prospective Observational Study on acute Appendicitis Worldwide (POSAW)
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Incidence of severe critical events in paediatric anaesthesia (APRICOT): a prospective multicentre observational study in 261 hospitals in Europe
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2018 ESC/ESH Guidelines for the management of arterial hypertension
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Elective surgery system strengthening: development, measurement, and validation of the surgical preparedness index across 1632 hospitals in 119 countries
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Diversity and ethics in trauma and acute care surgery teams: results from an international survey
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Team dynamics in emergency surgery teams: results from a first international survey
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A European Multi Lake Survey dataset of environmental variables, phytoplankton pigments and cyanotoxins
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Global variation in anastomosis and end colostomy formation following left‐sided colorectal resection
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Pooled analysis of WHO Surgical Safety Checklist use and mortality after emergency laparotomy
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Handling of the Covid-19 Pandemic and Its Effects on Bariatric Surgical Practice: Analysis of GENEVA Study Database
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Surgical site infection after gastrointestinal surgery in high-income, middle-income, and low-income countries: a prospective, international, multicentre cohort study
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Surgeons’ practice and preferences for the anal fissure treatment: results from an international survey
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Correction: Surgeons’ perspectives on artificial intelligence to support clinical decision-making in trauma and emergency contexts: results from an international survey
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Time for a paradigm shift in shared decision-making in trauma and emergency surgery? Results from an international survey
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Surgeons’ perspectives on artificial intelligence to support clinical decision-making in trauma and emergency contexts: results from an international survey
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Effects of hospital facilities on patient outcomes after cancer surgery: an international, prospective, observational study
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