Search results for: METABOLITES OF BROMHEXINE
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[NCh, IMa] Properties of novel materials
e-Learning Courses{mlang pl} Dyscyplina: nauki chemiczne, inżynieria materiałowa Zajęcia fakultatywne Prowadzący: prof. dr hab. inż. T. Klimczuk, WFTiMS Liczba godzin: 15 Forma zajęć: wykład {mlang} {mlang en} Discipline: chemical sciences, materials engineering facultative course Academic teacher: prof. dr hab. inż. T. Klimczuk, WFTiMS Total hours of training:15 teaching hours Course type: lecture {mlang}
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Organization of Investment Processes 2023/24
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History of Architecture II 2023/2024
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Essentials of Statistics (lab winter2023/24)
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TRANSFER OF ELECTRIC ENERGY [2021/22]
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Identification of Changes in Signals - 2023
e-Learning CoursesIdentification of Changes in Signals (practice) Identyfikacja Zmian w Sygnałach (ćw.)
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Physics of continuous media 2023/2024
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Application of AI Methods in Enterprise
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Applications of AI in Enterprise 2024
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TRANSFER OF ELECTRIC ENERGY [2024/25]
e-Learning CoursesCourse content: Basic information on the structure of the power system, the major devices (components) for generation, transmission and distribution of electricity. Active and reactive power generation and their sources. Power supply networks. Tasks, structure, parameters. AC and DC transmission of electricity. Equivalent diagrams of the components of the power system. Steady state load flow calculation: currents, voltage, power,...
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2022/2023 Methods of structural studies
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Methodology of scientific work 2023/2024
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Science of Scientific Writing 23/24
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Visualization of Economic Data - 2023/24
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[Soft Skills] Commercialization of scientific outcomes
e-Learning Courses{mlang pl} Soft Skills Zajęcia obowiązkowe dla doktorantów II roku Prowadzący: Agnieszka Krawczyk-Kłos, Damian Kuźniewski Liczba godzin: 5 {mlang} {mlang en} Soft Skills Obligatory course for 2nd-year PhD students Academic teacher: Agnieszka Krawczyk-Kłos, Damian Kuźniewski Total hours of training: 5 teaching hours {mlang}
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STRENGTH of MATERIALS TOWARDS APPLICATIONS (2024)
e-Learning CoursesThe SMTA DATE Course consists of the following problems to be discussed during the lectures: - Introduction to strength of materials towards applications - Fundamentals of modelling in strength of materials towards applications - Materials and basic structures - Fundamentals of modelling in strength of materials towards applications - Definition of environment and loads - General, energy-based and advanced methods for analysis...
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Condition monitoring of energy installations IDESII
e-Learning CoursesMeasurement errors and uncertainties. Industrial measurements in the energy industry. Measuring devices. The basics of control in industry. Measurement characteristics in complex energy systems. Distributed Control System (DCS) (KSR).
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The internationalization of the firm 2024
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History of Architecture I 2023/2024
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History of Architecture and Urbanism_23/24
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Theory of Elasticity and Plasticity 2023
e-Learning CoursesThis course discusses the general theory of elastic and plastic material behavior of solids.
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Management and economic of engineer projects
e-Learning CoursesLectures - 05 October-30 November, 2023 1. Project management: Engineers, projects, management, planning and scheduling, personnel and organizational, team building, project control, estimating and ordering. 2. Team building: personality types, team effectiveness. 3. Project management: WBS, Gantt, Earned Value Method, critical path, risk management. 4. Economic Engineering: Establishing economic equivalence, Interest: cost...
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Numerical Modeling of Hydrosystems 2023/2024
e-Learning CoursesKurs do przedmiotu NUMERICAL MODELING OF HYDROSYSTEMS Specjalność: Environmental Engineering (WILiŚ), II stopnia, stacjonarne dr hab. inż. Michał Szydłowski, prof. PG
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Applications of AI in Enterprise 2023
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Theory of Elasticity and Plasticity 2024
e-Learning CoursesThis course discusses the general theory of elastic and plastic material behavior of solids.
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Polychlorinated Biphenyls (PCBs) and Polycyclic Aromatic Hydrocarbons (PAHs): Sediments and Water Analysis
PublicationUnfavorable side effects of different forms of anthropogenic activities can be found anywhere in the world. One of the basic characteristics of pollutants entering marine and ocean waters is their spread and movement in the global ocean. A portion of the substances entering the marine environment is rapidly degraded by chemical processes occurring in the air, sediments, and water, thereby losing their toxic properties. The biggest...
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The concept of experience marketing - examples of practical application, (W), sem. 02, zimowy 22/23
e-Learning CoursesCelem przedmiotu jest zaznajomienie studentów z koncepcją marketingu doświadczeń, będącego coraz częściej obligatoryjną podstawą innowacyjnych strategii marketingowych przedsiębiorstw oraz ukazanie praktycznego zastosowania niniejszej idei (zarządzanie doświadczeniami, strategiczne moduły doświadczeń, mapowanie podróży klienta i pracownika firmy). The aim of the course is to familiarize students with the concept of experience...
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Metabolic transformations of antitumor imidazoacridinone, C-1311, with microsomal fractions of rat and human liver
PublicationWykazano, że enzymatyczna aktywacja jest konieczna dla aktywności biologicznej pochodnej C-1311 (Symadex R), która znajduje się w II fazie badań klinicznych. Zbadano przemiany enzymatyczne tego związku w obecności frakcji enzymatycznych mikrosomalnych komórek wątroby szczura i ludzkiej. Badania te wykazały, że związek C-1311 jest bardziej podatny na przemiany w obecności frakcji mikrosomalnej niż S9 i cytozolowej. Inkubacja związku...
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Analytical procedures used in examining human urine samples.
PublicationŹródłem informacji o stanie środowiska mogą być zarówno wyniki badań próbek części nieożywionej (woda, gleba, powietrze) jak i części biotycznej, w tym także tkanek i płynów ustrojowych człowieka, który jest nieustannie narażony na działanie szerokiego spektrum ksenobiotyków. Badanie płynów ustrojowych człowieka (głównie krwi i moczu) może być bardzo użyteczną i interesującą drogą do uzyskania informacji o stanie środowiska....
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The influence of different expression of CYP3A4 izoenzymes on metabolic pathway derivatives in human hepatoma cells
PublicationCelem przeprowadzonych badań było określenie różnic w metabolizmie pochodnych C-857 i C-1748 w komórkach ludzkiego nowotworu wątroby HepG2 oraz określenie wpływu na ich biotransformację w podwyższonej ekspresji izoenzymu CYP3A4 w tejże linii. Uzyskane wyniki wskazały, że związek C-857, jak również C-1748 metabolizuje w komórkach HepG2 oraz Hep3A4 do wielu reaktywnych, niestabilnych metabolitów. Różnice w biotransformacji były bardzo...
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Feasibility Study of Biohydrogen Production from Acid Cheese Whey via Lactate-Driven Dark Fermentation
PublicationThe high loading of lactic acid bacteria (LAB) present in cheese whey still limits its use as hydrogen feedstock. This study aims to investigate the feasibility of producing hydrogen from acid cheese whey via lactate-driven dark fermentation (LD-DF). Mesophilic batch fermentations were performed with delipidated acid cheese whey at a fixed pH of 5.8 and driven by an acidogenic bacterial culture containing LAB and lactate-oxidizing...
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International Journal Of Medical Research &Amp; Health Sciences (Ijmrhs)
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Fatal N-Ethylhexedrone Intoxication
PublicationN-Ethylhexedrone [2-(ethyloamino)-1-phenylhexan-1-one; α-ethylaminohexanophenone; NEH] is one of the most recent synthetic cathinones that appeared on the illegal market in late 2015. The majority of information concerning the model of consumption of NEH and its impact on the body originates only from self-reports from grey literature websites and drug forums. There are only limited data associated with the concentrations of NEH...
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Prediction of Overall In Vitro Microsomal Stability of Drug Candidates Based on Molecular Modeling and Support Vector Machines. Case Study of Novel Arylpiperazines Derivatives
PublicationOther than efficacy of interaction with the molecular target, metabolic stability is the primary factor responsible for the failure or success of a compound in the drug development pipeline. The ideal drug candidate should be stable enough to reach its therapeutic site of action. Despite many recent excellent achievements in the field of computational methods supporting drug metabolism studies, a well-recognized procedure to model...
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Mass spectrometry based identification of geometric isomers during metabolic stability study of a new cytotoxic sulfonamide derivatives supported by quantitative structure-retention relationships
PublicationA set of 15 new sulphonamide derivatives, presenting antitumor activity have been subjected to a metabolic stability study. The results showed that besides products of biotransformation, some additional peaks occurred in chromatograms. Tandem mass spectrometry revealed the same mass and fragmentation pathway, suggesting that geometric isomerization occurred. Thus, to support this hypothesis, quantitative structure-retention relationships...
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Covalent DNA modification by products of myrosinase catalysed glucosinolate degradation in cell-free system
PublicationThe bioactive phytochemicals found in Brassica vegetables belonging to glucosinolates (GLS) and especially the products of their degradation isothiocyanates (ITC) and indoles are regarded as the most promising cancer chemopreventive compounds. These secondary metabolites constitute defence system repelling or preventing the development of agrophages attacking brassica plants. The antibiological properties of these compounds suggest...
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Novel insights into conjugation of antitumor-active unsymmetrical bisacridine C-2028 with glutathione: characteristics of non-enzymatic and glutathione S-transferase-mediated reactions
PublicationUnsymmetrical bisacridines (UAs) are a novel potent class of antitumor-active therapeutics. A significant route of phase II drug metabolism is conjugation with glutathione (GSH), which can be non-enzymatic and/or catalyzed by GSH-dependent enzymes. The aim of this work was to investigate the GSH-mediated metabolic pathway of a representative UA, C 2028. GSH supplemented incubations of C-2028 with rat, but not with human, liver...
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Drug-drug interaction potential of antitumor acridine agent C-1748: The substrate of UDP-glucuronosyltransferases 2B7, 2B17 and the inhibitor of 1A9 and 2B7
PublicationBackground The compound 9-(2′-hydroxyethylamino)-4-methyl-1-nitroacridine (C-1748), the promising antitumor agent developed in our laboratory was determined to undergo phase I metabolic pathways. The present studies aimed to know its biotransformation with phase II enzymes – UDP-glucuronosyltransferases (UGTs) and its potential to be engaged in drug-drug interactions arising from the modulation of UGT activity. Methods UGT-mediated...
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Assessment of performance of unmanned maritime vehicles (USV, UUV, AUV) by CFD and MES investigation, PG_00053662
e-Learning CoursesThe course entitled "Assessment of Performance of Unmanned Maritime Vehicles" consists of the following problems to be discussed during the lectures (W): - major areas of application of UMV unmanned maritime vehicles, - sea environment, - types of UMV vehicles, - parameters, characteristics and features of UMV vehicles, - research, design, construction, implementation and operation of UMV vehicles, - systems of UMV vehicles...
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UDP-glukuronylotransferazy - białka siateczki śródplazmatycznej. Struktura i mechanizm działania
PublicationIzoenzymy UDP-glukuronylotransferazy (EC. 2.4.1.17), UGT, katalizują w organizmach ssaków reakcję koniugacji grupy glikozylowej pochodzącej z nukleotydu UDPGA z aglikonem. UDPGA jest przyłączany do odpowiedniej grupy funkcyjnej metabolitu I fazy, rzadziej związku wyjściowego, przez co polarność aglikonu i zdolność jego wydalania z komórki zwiększa się, a to w konsekwencji obniża efekt toksyczny.Struktura UGT zawiera 2 domeny. Domena...
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Substancje groźne, niebezpieczne i pożyteczne.Tom 1: Pierwiastki i związki nieorganiczne
PublicationLudzie od początku swojego istnienia byli narażeni na działanie szkodliwych substancji chemicznych. Pierwotnie były to groźne dla życia opary wulkaniczne, toksyczne minerały – takie, jak arszenik, rudy ołowiu czy rtęci, szkodliwe metabolity wtórne (toksyny) wytwarzane przez mikroorganizmy, rośliny i zwierzęta, a także produkty spalania substancji organicznych, w tym dymy z palących się lasów czy stepów, zawierające czad, dioksyny,...
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Theory of Urban Design 2022/23 - LECTURES
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Preparation of patent application (Przygotowanie wniosku patentowego)
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History of World Architecture I 2021/22
e-Learning CoursesThe course History of World Architecture (HWA I) is obligatory on the first semester of study at the Faculty of Architecture at Gdańsk University ofTechnology. It lasts 15 weeks, finishes with the exam, and consists of 15 two-hour lectures and 15 two-hour exercises. The merit of the course includes Western World architecture, beginning from Prehistory and Antiquity (Sumer, Egypt, Greece, Rome), up to the end of the Middle Ages....
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Basis of Chemical Technology - Lab - 2023/2024
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Selected prtoblems of heat ans mass transfer
e-Learning CoursesThew lecture presentes advanced topics in heat ans mass transfer
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2022 Ecological aspects of polymer package recycling
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Contemporary directions of development in mechanical engineering
e-Learning CoursesPresentation of new ways of development of different specialisations belonging to mechanical engineering
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History of World Architecture II 2021/2022
e-Learning CoursesThe course HISTORY OF WORLD II (HWA I) is obligatory in the second semester of study at the Faculty of Architecture at Gdańsk University ofTechnology. It lasts 15 weeks, finishes with the exam, and consists of 15 one-hour lectures and 7 two-hour exercises. The merit of the course includes Western World architecture, beginning from Renaissance (XVI c.), Baroque, Neoclassicism, and Historicism, up until the XIX century. The aim of the...
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Theory of Achitectural Design II 2021/2022
e-Learning CoursesProwadzący: dr hab. inż. arch. Jacek Krenz, prof. PG Architecture influenced by Art The aim of the set of lectures is to teach the method of creating an architectural form in a style that reflects a given topic drawn in the form of an ideogram. Creating architecture in this way makes it possible to endow the architectural form with meanings so that it becomes an important element of the existential space. An important feature...