dr hab. inż. Agnieszka Potęga
Zatrudnienie
- Profesor uczelni w Katedra Technologii Leków i Biochemii
Media społecznościowe
Kontakt
- agnieszka.potega@pg.edu.pl
Profesor uczelni
- Miejsce pracy
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Budynek B Wydz. Chemii
pokój 109 otwiera się w nowej karcie - agnieszka.potega@pg.edu.pl
Wybrane publikacje
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Glutathione-mediated conjugation of anticancer drugs: an overview of reaction mechanisms and biological significance for drug detoxification and bioactivation.
The effectiveness of many anticancer drugs depends on the creation of specific metabolites that may alter their therapeutic or toxic properties. One significant route of biotransformation is a conjugation of electrophilic compounds with reduced glutathione, which can be non-enzymatic and/or catalyzed by glutathione-dependent enzymes. Glutathione usually combines with anticancer drugs and/or their metabolites to form more polar...
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Phase I and phase II metabolism simulation of antitumor-active 2-hydroxyacridinone with electrochemistry coupled on-line with mass spectrometry.
Here, we report the metabolic profile and the results of associated metabolic studies of 2-hydroxyacridinone (2-OH-AC), the reference compound for antitumor-active imidazo- and triazoloacridinones. Electrochemistry coupled with mass spectrometry was applied to simulate the general oxidative metabolism of 2-OH-AC for the first time. The reactivity of 2-OH-AC products to biomolecules was also examined. The usefulness of the electrochemistry...
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Electrochemical simulation of metabolism for antitumor-active imidazoacridinone C-1311 and in silico prediction of drug metabolic reactions
The metabolism of antitumor-active 5-diethylaminoethylamino-8-hydroxyimidazoacridinone (C-1311) has been investigated widely over the last decade but some aspects of molecular mechanisms of its metabolic transformation are still not explained. In the current work, we have reported a direct and rapid analytical tool for better prediction of C-1311 metabolism which is based on electrochemistry (EC) coupled on-line with electrospray...
Uzyskane stopnie/tytuły naukowe
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2024-09-24
Nadanie stopnia naukowego
dr hab. inż. nauki chemiczne (Dziedzina nauk ścisłych i przyrodniczych) -
2011-06-01
Nadanie stopnia naukowego
dr inż. Biotechnologia - nauki chemiczne (Dziedzina nauk chemicznych)
wyświetlono 6529 razy