![Zdjęcie profilowe: dr inż. Barbara Horowska](/assets/barbara-horowska,29852-1/photo.png)
dr inż. Barbara Horowska
Zatrudnienie
Publikacje
Filtry
wszystkich: 1
Katalog Publikacji
Rok 2020
-
Design, synthesis and high antitumor potential of new unsymmetrical bisacridine derivatives towards human solid tumors, specifically pancreatic cancers and their unique ability to stabilize DNA G-quadruplexes
PublikacjaNew promising unsymmetrical bisacridine derivatives (UAs), have been developed. Three groupsincluding 36 compounds were synthesized by the condensation of 4-nitro or 4-methylacridinone, imi-dazoacridinone and triazoloacridinone derivatives with 1-nitroacridine compounds linked with anaminoalkyl chain. Cytotoxicity screening revealed the high potency of these compounds against severaltumor cell lines. Particularly, imidazoacridinone-1-nitroacridine...
wyświetlono 310 razy