Preparation, characterization and anti-colitis activity of curcumin-asafoetida complex encapsulated in turmeric nanofiber

Sreeraj Gopi; Augustine Amalraj; Shintu Jude; Karthik Varma; T.r. Sreeraj; Józef Haponiuk; Sabu Thomas

doi:10.1016/j.msec.2017.07.037

Preparation, characterization and anti-colitis activity of curcumin-asafoetida complex encapsulated in turmeric nanofiber

Abstrakt

Ulcerative colitis (UC) is a main form of inflammatory bowel disease (IBD). Asafoetida (ASF) and turmeric have traditionally been used for the treatment of various inflammatory diseases, including UC, because ASF is rich in sulfur compounds and turmeric contains curcumin (CUR). Turmeric nanofiber (TNF), the modified cell wall component of turmeric is considered to play important role in the human diet, health and can be used as a carrier agent to encapsulate bioactive components. A novel gut health product (GHP) was formulated by encapsulation of ASF and CUR complex onto TNF. The GHP was characterized by UPLC, GC-MS, FTIR, XRD, SEM with EDS and DSC studies. GHP was evaluated for anti-colitis activity in a rat model of 5% dextran sulfate sodium (DSS) induced UC. Treatment with GHP significantly attenuated the disease activity index, colitis score, histopathological changes and myeloperoxidase activity. GHP has significant protective effects against DSS induced colitis.

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Autorzy (7)

Sreeraj Gopi
Augustine Amalraj
Shintu Jude
Karthik Varma
T.r. Sreeraj
Józef Haponiuk prof. dr hab. inż.
Sabu Thomas

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Kategoria:: Publikacja w czasopiśmie
Typ:: artykuł w czasopiśmie wyróżnionym w JCR
Opublikowano w:: Materials Science & Engineering C-Materials for Biological Applications nr 81, strony 20 - 31,
ISSN: 0928-4931
Język:: angielski
Rok wydania:: 2017
Opis bibliograficzny:: Gopi S., Amalraj A., Jude S., Varma K., Sreeraj T., Haponiuk J., Thomas S.: Preparation, characterization and anti-colitis activity of curcumin-asafoetida complex encapsulated in turmeric nanofiber// Materials Science & Engineering C-Materials for Biological Applications. -Vol. 81, (2017), s.20-31
DOI:: Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.1016/j.msec.2017.07.037
Weryfikacja:: Politechnika Gdańska