Iwona Gabriel - Profil naukowy - MOST Wiedzy


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Adiunkt ze stop. nauk. dr hab.

Katedra Technologii Leków i Biochemii
Wydział Chemiczny
Miejsce pracy
Budynek B Wydziału Chemicznego pokój 105
(58) 348 60 78

Wybrane publikacje

  • Inhibitors of amino acids biosynthesis as antifungal agents

    Fungal microorganisms, including the human pathogenic yeast and filamentous fungi, are able to synthesize all proteinogenic amino acids, including nine that are essential for humans. A number of enzymes catalyzing particular steps of human-essential amino acid biosynthesis are fungi specific. Numerous studies have shown that auxotrophic mutants of human pathogenic fungi impaired in biosynthesis of particular amino acids exhibit...

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  • Phenotypic consequences of LYS4 gene disruption in Candida albicans

    - YEAST - 2014

    A BLAST search of the Candida Genome Database with the Saccharomyces cerevisiae LYS4 sequence known to encode homoaconitase (HA) revealed ORFs 19.3846 and 19.11327. Both alleles of the LYS4 gene were sequentially disrupted in Candida albicans BWP17 cells using PCR-based methodology. The null lys4Δ mutant exhibited lysine auxotrophy in minimal medium but was able to grow in the presence of L-Lys and α-aminoadipate, an intermediate...

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  • Characterization of two aminotransferases from Candida albicans

    Aminoadipate aminotransferase (AmAA) is an enzyme of α-aminoadipate pathway (AAP) for l-lysine biosynthesis. AmAA may also participated in biosynthesis or degradation of aromatic amino acids and in d-tryptophan based pigment production. The AAP is unique for fungal microorganisms. Enzymes involved in this pathway have specific structures and properties. These features can be used as potential molecular markers. Enzymes catalyzing...

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Uzyskane stopnie/tytuły naukowe

  • 2018-12-04

    Nadanie stopnia naukowego

    dr hab. inż. Nauki chemiczne (Dziedzina nauk ścisłych i przyrodniczych)
  • 2005-06-21

    Nadanie stopnia naukowego

    dr inż. Chemia (Dziedzina nauk chemicznych)

wyświetlono 325 razy