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- biologia medyczna (Dziedzina nauk medycznych i nauk o zdrowiu)
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- nauki chemiczne (Dziedzina nauk ścisłych i przyrodniczych)
Punkty Ministerialne: Pomoc
| Rok | Punkty | Lista |
|---|---|---|
| Rok 2024 | 100 | Ministerialna lista czasopism punktowanych 2024 |
| Rok | Punkty | Lista |
|---|---|---|
| 2024 | 100 | Ministerialna lista czasopism punktowanych 2024 |
| 2023 | 140 | Lista ministerialna czasopism punktowanych 2023 |
| 2022 | 100 | Lista ministerialna czasopism punktowanych (2019-2022) |
| 2021 | 100 | Lista ministerialna czasopism punktowanych (2019-2022) |
| 2020 | 100 | Lista ministerialna czasopism punktowanych (2019-2022) |
| 2019 | 100 | Lista ministerialna czasopism punktowanych (2019-2022) |
| 2018 | 25 | A |
| 2017 | 25 | A |
| 2016 | 25 | A |
| 2015 | 25 | A |
| 2014 | 25 | A |
| 2013 | 25 | A |
| 2012 | 25 | A |
| 2011 | 25 | A |
| 2009 | 20 | Wykaz punktowanych czasopism |
Model czasopisma:
Punkty CiteScore:
| Rok | Punkty |
|---|---|
| Rok 2023 | 8.4 |
| Rok | Punkty |
|---|---|
| 2023 | 8.4 |
| 2022 | 7.4 |
| 2021 | 5.6 |
| 2020 | 5.1 |
| 2019 | 4.9 |
| 2018 | 5.3 |
| 2017 | 4.4 |
| 2016 | 4.3 |
| 2015 | 3.8 |
| 2014 | 3.5 |
| 2013 | 3.7 |
| 2012 | 4.1 |
| 2011 | 4.1 |
Impact Factor:
Sherpa Romeo:
Prace opublikowane w tym czasopiśmie
Filtry
wszystkich: 31
Katalog Czasopism
Rok 2024
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c-Myc inhibition and p21 modulation contribute to unsymmetrical bisacridines-induced apoptosis and senescence in pancreatic cancer cells
PublikacjaBackground Pancreatic cancer (PC) is one of the most aggressive cancers and is the seventh leading cause of cancer-related death worldwide. PC is characterized by rapid progression and resistance to conventional treatments. Mutations in KRAS, CDKN2A, TP53, SMAD4/DPC4, and MYC are major genetic alterations associated with poor treatment outcomes in patients with PC. Therefore, optimizing PC therapy is a tremendous challenge. Unsymmetrical...
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In vitro biological evaluation of a novel folic acid-targeted receptor quantum dot−β−cyclodextrin carrier for C-2028 unsymmetrical bisacridine in the treatment of human lung and prostate cancers
PublikacjaTraditional small-molecule chemotherapeutics usually do not distinguish tumors from healthy tissues. However, nanotechnology creates nanocarriers that selectively deliver drugs to their site of action. This work is the next step in the development of the quantum dot−β−cyclodextrin−folic acid (QD−β−CD−FA) platform for targeted and selected delivery of C−2028 unsymmetrical bisacridine in cancer therapy.Herein, we report an initial...
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Sleep alterations in treatment-resistant depression patients undergoing ketamine treatment
PublikacjaBackground This study examines self-reported sleep alterations in treatment-resistant depression (TRD) inpatients following intravenous ketamine administration. Methods This is a post-hoc analysis of a naturalistic observational study, which enrolled 28 inpatients with treatment-resistant major depressive disorder and analyzed self-reported sleep changes (items 1–4; ‘insomnia’, ‘nighttime restlessness’, ‘early morning waking’,...
Rok 2023
Rok 2020
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Population pharmacokinetics of standard-dose meropenem in critically ill patients on continuous renal replacement therapy: a prospective observational trial
Publikacja -
Proof-of-concept study on improved efficacy of rHuEPO administered as a long-term infusion in rats
Publikacja
Rok 2018
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Comparison of the effects of rosuvastatin monotherapy and atorvastatin-ezetimibe combined therapy on the structure of erythrocyte membranes in patients with coronary artery disease
Publikacja -
Drug-drug interaction potential of antitumor acridine agent C-1748: The substrate of UDP-glucuronosyltransferases 2B7, 2B17 and the inhibitor of 1A9 and 2B7
PublikacjaBackground The compound 9-(2′-hydroxyethylamino)-4-methyl-1-nitroacridine (C-1748), the promising antitumor agent developed in our laboratory was determined to undergo phase I metabolic pathways. The present studies aimed to know its biotransformation with phase II enzymes – UDP-glucuronosyltransferases (UGTs) and its potential to be engaged in drug-drug interactions arising from the modulation of UGT activity. Methods UGT-mediated...
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Modulation of UDP-glucuronidation by acridinone antitumor agents C-1305 and C-1311 in HepG2 and HT29 cell lines, despite slight impact in noncellular systems.
PublikacjaBackground Among the studied antitumor acridinone derivatives developed in our laboratory, 5-dimethylaminopropylamino-8-hydroxytriazoloacridinone (C-1305) and 5-diethylaminoethylamino-8-hydroxyimidazoacridinone (C-1311) exhibited cytotoxic and antitumor properties against several cancer types and were selected to be evaluated in preclinical and early-phase clinical trials. In the present work, we investigated the impact of C-1305...
Rok 2017
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Effect of intensive lipid-lowering therapies on cholinesterase activity in patients with coronary artery disease
Publikacja -
High-dose testosterone enanthate supplementation boosts oxidative stress, but exerts little effect on the antioxidant barrier in sedentary adolescent male rat liver
Publikacja -
Temozolomide and sorafenib as programmed cell death inducers of human glioma cells
Publikacja
Rok 2016
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Imidazoacridinone antitumor agent C-1311 as a selective mechanism- based inactivator of human cytochrome P450 1A2 and 3A4 isoenzymes.
Publikacja5-Diethylaminoethylamino-8-hydroxyimidazoacridinone (C-1311), a promising antitumor agent that is also active against autoimmune diseases, was determined to be a selective inhibitor of the cytochrome P450 (CYP) 1A2 and 3A4 isoenzymes. Therefore, C-1311 might modulate the effectiveness of other drugs used in multidrug therapy. The present work aimed to identify the mechanism of the observed C-1311-mediated inactivation of CYP1A2...
Rok 2015
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Detrimental effects of chemotherapeutics and other drugs on the endothelium: A call for endothelial toxicity profiling
Publikacja -
Mesoporous silica nanoflakes – Biocompatibility, cellular uptake and drug transport
Publikacja -
The effect of interleukin-35 on the integrity, ICAM-1 expression and apoptosis of human aortic smooth muscle cells
Publikacja
Rok 2014
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Catalase activity in blood fractions of patients with sporadic ALS
Publikacja -
Chronic treatment with zinc hydroaspartate induces anti-inflammatory and anti-ulcerogenic activity in rats
Publikacja -
Pharmacokinetics and pharmacodynamics of propofol in children undergoing different types of surgeries
Publikacja -
The influence of the time of day on midazolam pharmacokinetics and pharmacodynamics in rabbits
Publikacja
Rok 2013
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Assessing circadian rhythms during prolonged midazolam infusion in the pediatric intensive care unit (PICU) children
Publikacja -
Possible contribution of IGF-1 to depressive disorder
Publikacja
Rok 2012
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Diversity of frequency-modulated 50-kHz vocalization response to intermittent amphetamine treatment in Sprague-Dawley rats
Publikacja -
Maternal immune activation leads to age-related behavioral and immunological changes in male rat offspring - the effect of antipsychotic drugs
Publikacja -
New conjugates of muramyl dipeptide and nor-muramyl dipeptide linked to tuftsin and retro-tuftsin derivatives significantly influence their biological activity
PublikacjaOpisano syntezę nowych koniugatów MDP i nor-MDP z pochodnymi tuftsyny i retro-tuftsyny zawierającymi wiązanie izopeptydowe pomiędzy epsilon-aminową grupą lizyny, a karboksylową grupą Ala, Gly czy Val. Zbadano ich aktywność biologiczną, m.in. profil cytokinowy.
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Pharmacokinetics and pharmacodynamics of propofol in patients undergoing abdominal aortic surgery
Publikacja -
Potential pitfalls of propofol target controlled infusion delivery related to its pharmacokinetics and pharmacodynamics
Publikacja
Rok 2011
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Natural and synthetic acridines/acridones as antitumor agents: their biological activities and methods of synthesis.
PublikacjaPraca stanowi przegląd opisanych w literaturze chemicznej modyfikacji struktur naturalnych i syntetycznych pochodnych akrydyny i akrydonu. Artykuł obejmuje swym zakresem metody syntezy, a także wpływ budowy cząsteczek tych związków na ich aktywność przeciwnowotworową oraz mechanizm działania.
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Therapeutic potential of adenosine analogues and conjugates
PublikacjaZaprezentowano przegląd literatury chemicznej na temat analogów i koniugatów adenozyny oraz ich potencjalne zastosowanie terapeutyczne. Zwrócono także uwagę na ich oddziaływanie z receptorami adenozyny.
Rok 2009
wyświetlono 1840 razy