dr hab. inż. Marek Wojciechowski
Zatrudnienie
- Profesor uczelni w Katedra Technologii Leków i Biochemii
Obszary badawcze
Media społecznościowe
Kontakt
- mw@pg.edu.pl
Profesor uczelni
- Miejsce pracy
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Budynek B Wydz. Chemii
pokój 4 otwiera się w nowej karcie - Telefon
- (58) 347 19 93, (58) 347 11 16
- mw@pg.edu.pl
Wybrane publikacje
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A Highly Selective Biosensor Based on Peptide Directly Derived from the HarmOBP7 Aldehyde Binding Site
This paper presents the results of research on determining the optimal length of a peptide chain to eectively bind octanal molecules. Peptides that map the aldehyde binding site in HarmOBP7 were immobilized on piezoelectric transducers. Based on computational studies, four Odorant Binding Protein-derived Peptides (OBPPs) with dierent sequences were selected. Molecular modelling results of ligand docking with selected peptides were...
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Determination of long-chain aldehydes using a novel quartz crystal microbalance sensor based on a biomimetic peptide
There is an increasingly popular trend aimed at improvement of fundamental metrological parameters of sensors via implementation of materials mimicking biological olfactory systems. This study presents investigation on usefulness of the peptide mimicking HarmOBP7 region as a receptor element of the piezoelectric sensor for selective analysis of long-chain aldehydes. Identification of odorant binding proteins creates new possibilities...
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Structural factors affecting affinity of cytotoxic oxathiole-fused chalcones toward tubulin
Synthesis, in vitro cytotoxic activity, and interaction with tubulin of (E)-1-(6-alkoxybenzo[d][1,3]oxathiol- 5-yl)-3-phenylprop-2-en-1-one derivatives (2) are described. Some of the compounds demonstrated cytotoxic activity at submicromolar concentrations, and the activity could be related to interaction with tubulin at the colchicine binding site. Interaction of selected derivatives with tubulinwas evaluated using molecular modeling,...
Uzyskane stopnie/tytuły naukowe
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2018-04-11
Nadanie stopnia naukowego
dr hab. inż. Biotechnologia - nauki chemiczne (Dziedzina nauk chemicznych) -
1998-12-16
wyświetlono 2231 razy