
dr inż. Mateusz Daśko
Zatrudnienie
- Adiunkt w Katedra Chemii Nieorganicznej
Media społecznościowe
Kontakt
- mateusz.dasko@pg.edu.pl
Adiunkt
- Miejsce pracy
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Budynek A Wydz. Chemii
pokój 47 otwiera się w nowej karcie - Telefon
- (58) 347 29 83
- mateusz.dasko@pg.edu.pl
Wybrane publikacje
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Selected organophosphorus compounds with biological activity. Applications in medicine
The purpose of this article is to provide an overview of the latest applications of organophosphorus compounds (OPs) that exhibit biological activity. A large family of OPs have become popular in recent years. The practical application of OPs in modern medicine has been attributed to their unique properties. In this article, the methods used to select these compounds will be emphasized. This paper will first outline the findings...
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Synthesis of bicoumarin thiophosphate derivatives as steroid sulfatase inhibitors
Based on the frameworks of 7-hydroxy-2,3-dihydro-1H-cyclopenta[c]chromen-4-one, 3-hydroxy- 7,8,9,10-tetrahydro-6H-benzo[c]chromen-6-one and 3-hydroxy-8,9,10,11-tetrahydro-7H-cyclohepta[c] chromen-6-one, a series of bicoumarin thiophosphate analogs have been synthesized and biologically evaluated. Additionally, their binding modes have been modeled using docking techniques. The inhibitory properties of the synthesized compounds...
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Synthesis and biological evaluation of fluorinated N-benzoyl and N-phenylacetoyl derivatives of 3-(4-aminophenyl)-coumarin-7-O-sulfamate as steroid sulfatase inhibitors
In the present work, we report convenient methods for the synthesis of 3-(4-aminophenyl)-coumarin-7-O-sulfamate derivatives N-acylated with fluorinated analogues of benzoic or phenylacetic acid as steroid sulfatase (STS) inhibitors. The design of these potential STS inhibitors was supported by molecular modeling techniques. Additionally, computational docking methods were used to determine the binding modes of the synthesized inhibitors...
Uzyskane stopnie/tytuły naukowe
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2018-10-09
Nadanie stopnia naukowego
dr inż. Nauki chemiczne (Dziedzina nauk ścisłych i przyrodniczych)
wyświetlono 2742 razy