dr inż. Miłosz Wieczór
Zatrudnienie
- Adiunkt w Katedra Chemii Fizycznej
Media społecznościowe
Wybrane publikacje
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Splice variants of mitofusin 2 shape the endoplasmic reticulum and tether it to mitochondria
In eukaryotic cells, different organelles interact at membrane contact sites stabilized by tethers. Mitochondrial mitofusin 2 (MFN2) acts as a membrane tether that interacts with an unknown partner on the endoplasmic reticulum (ER). In this work, we identified the MFN2 splice variant ERMIT2 as the ER tethering partner of MFN2. Splicing of MFN2 produced ERMIT2 and ERMIN2, two ER-specific variants. ERMIN2 regulated ER morphology,...
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Effective Drug Concentration and Selectivity Depends on Fraction of Primitive Cells
Poor efficiency of chemotherapeutics in the eradication of Cancer Stem Cells (CSCs) has been driving the search for more active and specific compounds. In this work, we show how cell density-dependent stage culture profiles can be used in drug development workflows to achieve more robust drug activity (IC50 and EC50) results. Using flow cytometry and light microscopy, we characterized the cytological stage profiles of the HL-60-,...
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A first-principles study of electron attachment to the fully hydrated bromonucleobases
Degradation mechanism of four brominated nucleobases (BrX), potential DNA radiosensitizers, is studied in explicit water solution, using ab initio molecular dynamics. Several fs long dynamics is needed to localize an electron on the nucleobase. Produced by electron attachment BrX anion radical degrades through the bromide anion abstraction, barrier-free (purines) or with low barrier (pyrimidines), to a reactive nucleobase radical....
Uzyskane stopnie/tytuły naukowe
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2019-10-01
Nadanie stopnia naukowego
dr inż. nauki chemiczne (Dziedzina nauk ścisłych i przyrodniczych)
wyświetlono 2321 razy