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Katalog Publikacji

Rok 2023
Rok 2022
Rok 2021
  • Post-Effort Changes in Autophagy- and Inflammation-Related Gene Expression in White Blood Cells of Healthy Young Men
    Publikacja
    • D. Kostrzewa-Nowak
    • A. Trzeciak-Ryczek
    • P. Wityk
    • D. Cerembrowsa-Lech
    • R. Nowak

    - Cells - Rok 2021

    Acute, strenuous physical exertion requiring high levels of energy production induces the production of reactive oxygen species and metabolic disturbances that can damage the mitochondria. Thus, selective autophagic elimination of defective mitochondria may improve resistance to oxidative stress and potentially to inflammation. The main goal of this study was to evaluate the impacts of intense effort on changes in the expression...

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  • Post-match recovery profile of leukocyte cell subsets among professional soccer players
    Publikacja
    • D. Kostrzewa-Nowak,
    • P. Wityk
    • A. Ciechanowicz
    • R. Nowak

    - Scientific Reports - Rok 2021

    This study assessed the impact of cumulative match time on the distribution of CD45+ cell subtests in the capillary blood of professional soccer players. Twenty-two males (aged 18–30 years) took part in the 36-week study. Participants playing up to 540 in cumulative match time and less than 30 min in each single match during the observation period formed the control group. White blood cell (WBC) phenotyping and creatine kinase...

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  • The Many Faces of Enterococcus spp.—Commensal, Probiotic and Opportunistic Pathogen
    Publikacja

    - Microorganisms - Rok 2021

    Enterococcus spp. are Gram-positive, facultative, anaerobic cocci, which are found in the intestinal flora and, less frequently, in the vagina or mouth. Enterococcus faecalis and Enterococcus faecium are the most common species found in humans. As commensals, enterococci colonize the digestive system and participate in the modulation of the immune system in humans and animals. For many years reference enterococcal strains have...

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  • X-ray and UV Radiation Damage of dsDNA/Protein Complexes
    Publikacja

    - MOLECULES - Rok 2021

    Radiation and photodynamic therapies are used for cancer treatment by targeting DNA. However, efficiency is limited due to physico-chemical processes and the insensitivity of native nucleobases to damage. Thus, incorporation of radio- and photosensitizers into these therapies should increase both efficacy and the yield of DNA damage. To date, studies of sensitization processes have been performed on simple model systems, e.g.,...

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Rok 2020
Rok 2019
Rok 2018
Rok 2017
Rok 2016
  • 5-Bromo-2′-deoxycytidine—a potential DNA photosensitizer
    Publikacja

    - ORGANIC & BIOMOLECULAR CHEMISTRY - Rok 2016

    A double-stranded oligonucleotide, 80 base pairs in length, was multiply labeled with 5-bromo-2′-deoxycytidine (BrdC) using polymerase chain reaction (PCR). The modified oligonucleotide was irradiated with 300 nm photons and its damage was assayed by employing DHPLC, LC-MS and denaturing polyacrylamide gel electrophoresis (PAGE). Two types of damage were demonstrated, namely, single strand breaks (SSBs) and intrastrand cross-links...

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Rok 2015
Rok 2014
  • A first-principles study of electron attachment to the fully hydrated bromonucleobases
    Publikacja

    - CHEMICAL PHYSICS LETTERS - Rok 2014

    Degradation mechanism of four brominated nucleobases (BrX), potential DNA radiosensitizers, is studied in explicit water solution, using ab initio molecular dynamics. Several fs long dynamics is needed to localize an electron on the nucleobase. Produced by electron attachment BrX anion radical degrades through the bromide anion abstraction, barrier-free (purines) or with low barrier (pyrimidines), to a reactive nucleobase radical....

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  • Molecular Recognition in Complexes of TRF Proteins with Telomeric DNA
    Publikacja

    Telomeres are specialized nucleoprotein assemblies that protect the ends of linear chromosomes. In humans and many other species, telomeres consist of tandem TTAGGG repeats bound by a protein complex known as shelterin that remodels telomeric DNA into a protective loop structure and regulates telomere homeostasis. Shelterin recognizes telomeric repeats through its two major components known as Telomere Repeat-Binding Factors, TRF1...

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