Piotr Sass - Publikacje - MOST Wiedzy

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Rok 2023
Rok 2022
Rok 2021
  • Activation of endogenous regenerative potential in mammals using epigenetic inhibitor zebularine
    Publikacja

    - Rok 2021

    In this work, a nucleoside inhibitor of DNA methyltransferases, zebularine, was investigated as a wound healing and regeneration promoting agent. It was found that a high dose of intraperitoneally delivered zebularine improved punch wound closure in the ear pinna in mice. Both cytidine, a zebularine analogue, and uridine, a zebularine metabolite, did not promote ear pinna hole closure. The effect of zebularine on ear pinna healing...

  • Functionalized Peptide Fibrils as a Scaffold for Active Substances in Wound Healing
    Publikacja
    • J. Sawicka
    • E. Iłowska
    • M. Deptuła
    • P. Sosnowski
    • P. Sass
    • K. Czerwiec
    • K. Chmielewska
    • A. Szymańska
    • Z. Pietralik-Molińska
    • M. Kozak... i 3 innych

    - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES - Rok 2021

    Technological developments in the field of biologically active peptide applications in medicine have increased the need for new methods for peptide delivery. The disadvantage of peptides as drugs is their low biological stability. Recently, great attention has been paid to self-assembling peptides that can form fibrils. Such a formulation makes bioactive peptides more resistant to enzymatic degradation and druggable. Peptide fibrils...

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Rok 2020
  • Development of a Peptide Derived from Platelet-Derived Growth Factor (PDGF-BB) into a Potential Drug Candidate for the Treatment of Wounds
    Publikacja
    • M. Deptuła
    • P. Karpowicz
    • A. Wardowska
    • P. Sass
    • P. Sosnowski
    • A. Mieczkowska
    • N. Filipowicz
    • M. Dzierżyńska
    • J. Sawicka
    • E. Nowicka... i 14 innych

    - Advances in Wound Care - Rok 2020

    Objective: This study evaluated the use of novel peptides derived from platelet-derived growth factor (PDGF-BB) as potential wound healing stimulants. One of the compounds (named PDGF2) was subjected for further research after cytotoxicity and proliferation assays on human skin cells. Further investigation included evaluation of: migration and chemotaxis of skin cells, immunological and allergic safety, the transcriptional analyses...

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  • Imunofan—RDKVYR Peptide—Stimulates Skin Cell Proliferation and Promotes Tissue Repair
    Publikacja
    • J. Sawicka
    • M. Dzierżyńska
    • A. Wardowska
    • M. Deptuła
    • P. Rogujski
    • P. Sosnowski
    • N. Filipowicz
    • A. Mieczkowska
    • P. Sass
    • A. Pawlik... i 19 innych

    - MOLECULES - Rok 2020

    Regeneration and wound healing are vital to tissue homeostasis and organism survival. One of the biggest challenges of today’s science and medicine is finding methods and factors to stimulate these processes in the human body. Effective solutions to promote regenerative responses will accelerate advances in tissue engineering, regenerative medicine, transplantology, and a number of other clinical specialties. In this study, we...

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Rok 2019
Rok 2018
Rok 2017
  • Transcriptomic responses to wounding: meta-analysis of gene expression microarray data
    Publikacja

    - BMC GENOMICS - Rok 2017

    Background A vast amount of microarray data on transcriptomic response to injury has been collected so far. We designed the analysis in order to identify the genes displaying significant changes in expression after wounding in different organisms and tissues. This meta-analysis is the first study to compare gene expression profiles in response to wounding in as different tissues as heart, liver, skin, bones, and spinal cord, and...

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