Adipokine and cytokine levels in non-functioning adrenal incidentalomas (NFAI) - Publikacja - MOST Wiedzy

Wyszukiwarka

Adipokine and cytokine levels in non-functioning adrenal incidentalomas (NFAI)

Abstrakt

Due to the fact that overweight or obesity is accompanied by hormonally active adrenal tumors: Cushing Syndrome-(CS) and Subclinical Cushing Syndrome (SCS), it is of high interest the correlation between different adipokines and cytokines secreted by adipose tissue, with metabolic disorders and hormonal activity in this group. Even in non-functioning adrenal incidentalomas (NFAI) elevated risk for cardiovascular disease and metabolic syndrome was demonstrated. The aim of the study was to investigate plasma adiponectin, leptin, resistin, tumor necrosis factor α (TNFα), interleukin 6 (IL6) and monocyte chemoattractant protein 1 (MCP1) levels in patients with NFAIs and healthy subjects. The study included 18 NFAI patients and 18 healthy subjects. The groups were homogeneous in terms of age, sex and body mass index (BMI). Patients with NFAI showed significantly higher circulating levels of pro-inflammatory cytokines compared to healthy controls (MCP 1: p < 0.001; TNFα p = 0.021; IL6 p = 0.012). On the other hand, adiponectin concentration was significantly lower in the NFAI group (p = 0.034). The serum leptin and resistin concentrations did not differ significantly between the two groups. Acquired results were not dependent on glucocorticoid and catecholamine secretion in NFAI patients. Also, there were no clear correlations between BMI and cytokine levels. It is possible that increased risk for cardiovascular and metabolic diseases reported in NFAI patients is at least partially dependent on adipose tissue activity.

Cytowania

  • 5

    CrossRef

  • 0

    Web of Science

  • 4

    Scopus

Cytuj jako

Pełna treść

pełna treść publikacji nie jest dostępna w portalu

Informacje szczegółowe

Kategoria:
Publikacja w czasopiśmie
Typ:
artykuł w czasopiśmie wyróżnionym w JCR
Opublikowano w:
ENDOCRINE JOURNAL nr 65, wydanie 8, strony 849 - 858,
ISSN: 0918-8959
Język:
angielski
Rok wydania:
2018
Opis bibliograficzny:
Babinska A., Kaszubowski M. F., Sworczak K.: Adipokine and cytokine levels in non-functioning adrenal incidentalomas (NFAI)// ENDOCRINE JOURNAL. -Vol. 65, iss. 8 (2018), s.849-858
DOI:
Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.1507/endocrj.ej18-0066
Weryfikacja:
Politechnika Gdańska

wyświetlono 8 razy

Publikacje, które mogą cię zainteresować

Meta Tagi