Assessment of the usefulness of bacterial cellulose produced by Gluconacetobacter xylinus E25 as a new biological implant - Publikacja - MOST Wiedzy

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Assessment of the usefulness of bacterial cellulose produced by Gluconacetobacter xylinus E25 as a new biological implant

Abstrakt

Bionanocellulose (BNC) is a clear polymer produced by the bacterium Gluconacetobacter xylinus. In our current study, “Research on the use of bacterial nanocellulose (BNC) in regenerative medicine as a function of the biological implants in cardiac and vascular surgery”, we carried out material analysis, biochemical analysis, in vitro tests and in vivo animal model testing. In stage 1 of the project, we carried out physical and biological tests of BNC. This allowed us to modify subsequent samples of bacterial bionanocellulose. Finally, we obtained a sample that was accepted for testing on an animal model. That sample we define BNC1. Patches of BNC1 were then implanted into pigs' vessel walls. During the surgical procedures, we evaluated the technical aspects of sewing in the bioimplant, paying special attention to bleeding control and tightness of the suture line and the BNC1 bioimplant itself. We carried out studies evaluating the reaction of an animal body to an implantation of BNC1 into the circulatory system, including the general and local inflammatory reaction to the bioimplant. These studies allowed us to document the potential usefulness of BNC as a biological implant of the circulatory system and allowed for additional modifications of the BNC to improve the properties of this new implantable biological material.

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Magdalena Kołaczkowska, Piotr Siondalski, Maciej Kowalik, Rafał Pęksa, Aldona Długa, Wacław Zając, Paulina Dederko, Ilona Kołodziejska, Edyta Malinowska-Pańczyk, Izabela Sinkiewicz, Hanna Staroszczyk, Agata Śliwińska, Alicja Stanisławska, Marek Szkodo, Paulina Pałczyńska,, Grzegorz Jabłoński, Andrzej Borman, Piotr Wilczek. (2019). Assessment of the usefulness of bacterial cellulose produced by Gluconacetobacter xylinus E25 as a new biological implant, 97, 302-312. https://doi.org/10.1016/j.msec.2018.12.016

Informacje szczegółowe

Kategoria:
Publikacja w czasopiśmie
Typ:
artykuł w czasopiśmie wyróżnionym w JCR
Opublikowano w:
Język:
angielski
Rok wydania:
2019
Opis bibliograficzny:
Kołaczkowska M., Siondalski P., Kowalik M., Pęksa R., Długa A., Zając W., Dederko P., Kołodziejska I., Malinowska-Pańczyk E., Sinkiewicz I., Staroszczyk H., Śliwińska A., Stanisławska A., Szkodo M., Pałczyńska, P., Jabłoński G., Borman A., Wilczek P.: Assessment of the usefulness of bacterial cellulose produced by Gluconacetobacter xylinus E25 as a new biological implant// Materials Science & Engineering C-Materials for Biological Applications. -Vol. 97, (2019), s.302-312
Źródła finansowania:
  • Działalność statutowa
  • Działalność statutowa

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