Abstrakt

Despite the development of science and technology progress so far there have not been found effective drugs for cancer. Many coordination compounds were investigated due to their antitumor potential. The most known cis-diamminedichloroplatinum(II) is used as anti-cancer therapeutic agent. The copper complexes are the coordination compounds possessing anti-tumour properties. Their capability to kill cancer cells is mainly linked to the induction of oxidative stress. [1] Among various copper complexes tested as potential anti-cancer drugs, strong antitumor activity was found in the bis(acetato)bis(imidazole)copper(II) complex. In the 50% inhibition dose (ID50) of the cell growth tests using the mouse cancer cell line B16 melanoma, the cytotoxic effect of this compound (20 ng/mL) was equivalent to that of the therapeutic drug cis-DDP (8 ng/mL) and better than that of mitomycin C (100 ng/mL). [2] Previously investigated copper complexes with imidazole ligand showed moderate, concentration dependent cytotoxic effects. [3] We have synthesized and investigated the anti-cancer effect of copper (II) complex with (4(5)-methylimidazole) and pivalato ligands. The compound is more lipophilic than bis(acetato)bis(imidazole)copper(II) so we have expected greater cytotoxic activity than in case of previously investigated compound. The investigation has been limited due to small solubility of the examined compound in ethanol. The influence of the compound to cell line growth is noticeable. References: 1. S. Tardito, L. Marchiò (2009) Curr. Med. Chem. 16: 1325-1348. 2. H. Tamura, H. Imai (1987) J. Am. Chem. Soc. 109: 6870-6871. 3. S. Godlewska, J. Jezierska, K. Baranowska, E. Augustin, A. Dołęga (2013) Polyhedron 65:288-297

Autorzy (5)