Bisphenols (A, S, and F) affect the basic hormonal activity determined for pharmaceuticals – Study of Saccharomyces cerevisiae - Publikacja - MOST Wiedzy

Twoje konto

zaloguj

Wyszukiwarka

Bisphenols (A, S, and F) affect the basic hormonal activity determined for pharmaceuticals – Study of Saccharomyces cerevisiae

Abstrakt

Pharmaceuticals and analogs of bisphenol A (BPA) are increasingly threatening environmental pollutants. In this study, mixtures of selected pharmaceuticals (diclofenac sodium salt, chloramphenicol, oxytetracycline hydrochloride, fluoxetine hydrochloride, estrone, ketoprofen, progesterone, gemfibrozil and androstenedione) were prepared with BPA and its two analogs (namely, bisphenols F and S) at such ratios to reflect environmentally detectable levels. Then, the mixture solutions were studied with a XenoScreen YES/YAS assay to determine the variations in the initial hormonal response of each pharmaceutical compound due to the presence of a bisphenol analog. The results obtained were modeled with the concentration addition (CA) and independent action (IA) approaches, the trueness of which was studied with model deviation ratios (MDR). The estrogenic agonistic activity of the drugs studied was most strongly affected by the presence of BPA in solution (twenty-one cases of synergy observed for CA models versus twelve cases of antagonism in the case of IA predictions). BPS shows a strong agonistic estrogenic impact on most of the drugs studied at medium and high concentration levels; androgenic agonistic activity was also impaired with elevated concentrations of BPS.

Cytowania

  • 1 4

    CrossRef

  • 0

    Web of Science

  • 1 4

    Scopus

Autorzy (3)

Cytuj jako

Pełna treść

pobierz publikację
pobrano 64 razy
Wersja publikacji
Accepted albo Published Version
Licencja
Creative Commons: CC-BY-NC-ND otwiera się w nowej karcie

Słowa kluczowe

Informacje szczegółowe

Kategoria:
Publikacja w czasopiśmie
Typ:
artykuł w czasopiśmie wyróżnionym w JCR
Opublikowano w:
ENVIRONMENTAL POLLUTION nr 246, strony 914 - 920,
ISSN: 0269-7491
Język:
angielski
Rok wydania:
2019
Opis bibliograficzny:
Kudłak B., Wieczerzak M., Namieśnik J.: Bisphenols (A, S, and F) affect the basic hormonal activity determined for pharmaceuticals – Study of Saccharomyces cerevisiae// ENVIRONMENTAL POLLUTION. -Vol. 246, (2019), s.914-920
DOI:
Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.1016/j.envpol.2018.12.052
Źródła finansowania:
  • NCN Miniatura 2017/01/X/ST4/00474
Weryfikacja:
Politechnika Gdańska

wyświetlono 203 razy

Publikacje, które mogą cię zainteresować

Binary Mixtures of Selected Bisphenols in the Environment: Their Toxicity in Relationship to Individual Constituents

2018

Impact of selected drugs and their binary mixtures on the germination of Sorghum bicolor (sorgo) seeds

2018

Impact of inorganic ions and pH variations on toxicity and endocrine potential of selected environmentally relevant pharmaceuticals

2018

Assessing ecotoxicity and the endocrine potential of selected phthalates, BADGE and BFDGE derivatives in relation to environmentally detectable levels

2018
Meta Tagi