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Comprehensive determination of flavouring additives and nicotine in e-cigarette refill solutions. Part II: Gas-chromatography–mass spectrometry analysis

Abstrakt

Flavouring compounds are an essential part of e-liquid products for cigarettes. In general, they are regarded as safe for ingestion, but they may have unrecognized risks when they are inhaled. In some cases, manufactures do not currently abide by the Tobacco Products Directive (2014/40/EU) and do not declare the detailed contents of e-liquids on their labels. To help evaluate the health impact of flavouring substances, there is a need for comprehensive approaches to determine their concentrations in e-liquids. For this purpose, a GC-EI-MS method was developed and validated for the simultaneous determination of 46 commonly used flavour additives in e-liquids. The proposed method performed well in terms of the key validation parameters: accuracy (84–113%), inter-/intra-day precision: 0.1–10% and 1–11%, respectively, and sensitivity (limit of detection: 3–87 ng/mL). The sample preparation step was based on a simple “dilute & shoot” approach. This study is a complementary method to the LC–MS/MS procedure described in Part I. Both approaches are suitable for the comprehensive determination of 88 flavouring compounds and nicotine and can be used as tools for the rapid evaluation of the quality and safety of e-cigarette products.

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Creative Commons: CC-BY-NC-ND otwiera się w nowej karcie

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Kategoria:
Publikacja w czasopiśmie
Typ:
artykuł w czasopiśmie wyróżnionym w JCR
Opublikowano w:
JOURNAL OF CHROMATOGRAPHY A nr 1517, strony 156 - 164,
ISSN: 0021-9673
Język:
angielski
Rok wydania:
2017
Opis bibliograficzny:
Aszyk J., Woźniak M., Kubica P., Kot-Wasik A., Namieśnik J., Wasik A.: Comprehensive determination of flavouring additives and nicotine in e-cigarette refill solutions. Part II: Gas-chromatography–mass spectrometry analysis// JOURNAL OF CHROMATOGRAPHY A. -Vol. 1517, (2017), s.156-164
DOI:
Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.1016/j.chroma.2017.08.057
Bibliografia: test
  1. B.I.S. Research, Electronic Cigarette and E Vapor (Vaporizer) Market Research Reports, 2016.
  2. J.L. Barrington-Trimis, J.M. Samet, R. McConnell, Flavorings in electronic cigarettes: an unrecognized respiratory health hazard, JAMA 12 (2014), 2493-2394. otwiera się w nowej karcie
  3. J.G. Allen, S.S. Flanigan, M. LeBlanc, J. Vallarino, P. MacNaughton, J.H. Stewart, D.C. Christiani, Flavoring chemicals in e-cigarettes: diacetyl, 2,3-pentanedione, and acetoin in a sample of 51 products, including fruit-, candy-, and cocktail-flavored e-cigarettes, Environ. Health Perspect. 124 (2015) 733-739. otwiera się w nowej karcie
  4. S. Costigan, C. Meredith, An approach to ingredient screening and toxicological risk assessment of flavours in e-liquids, Regul. Toxicol. Pharmacol. 15 (2015) 361-369. otwiera się w nowej karcie
  5. M. Famele, C. Ferranti, C. Abenavoli, L. Palleschi, R. Mancinelli, R. Draisci, The chemical components of electronic cigarette cartridges and refill fluids: review of analytical methods, Nicotine Tob. Res. 17 (2014) 217-219. otwiera się w nowej karcie
  6. J.W. Flora, C.T. Wilkinson, J.W. Wilkinson, P.J. Lipowicz, J.A. Skapars, A. Anderson, J.H. Miller, Method for the determination of carbonyl compounds in e-cigarette aerosols, J. Chromatogr. Sci. 55 (2017) 142-148. otwiera się w nowej karcie
  7. P. Kubica, A. Kot-Wasik, A. Wasik, J. Namieśnik, Dilute & Shoot approach for rapid determination of trace amounts of nicotine in zero-level e-liquids by reversed phase liquid chromatography and hydrophilic interactions liquid chromatography coupled with tandem mass spectrometry-electrospray ionization, J. Chromatogr. A 1289 (2013) 13-18. otwiera się w nowej karcie
  8. V. Bansal, K.H. Kim, Review on quantitation methods for hazardous pollutants released by e-cigarette (EC) smoking, TrAC 78 (2016) 120-133. otwiera się w nowej karcie
  9. Y.H. Kim, K.H. Kim, A novel method to quantify the emission and conversion of VOCs in the smoking of electronic cigarettes, Sci. Rep. 5 (2015) 1-9. otwiera się w nowej karcie
  10. J.S. Herrington, C. Myers, Electronic cigarette solutions and resultant aerosol profiles, J. Chromatogr. A 1418 (2015) 192-199. otwiera się w nowej karcie
  11. O. Geiss, I. Bianchi, J. Barrero-Moreno, Correlation of volatile carbonyl yields emitted by e-cigarettes with the temperature of the heating coil and the perceived sensorial quality of the generated vapours, Int. J. Hyg. Environ. Health 219 (2016) 268-277. otwiera się w nowej karcie
  12. T.R. Mcauley, P.K. Hopke, J. Zhao, S. Babaian, Comparison of the effects of e-cigarette vapor and cigarette smoke on indoor air quality, Inhal. Toxicol. 24 (2012) 850-857. otwiera się w nowej karcie
  13. M.P. Kavvalakis, P.D. Stivaktakis, M.N. Tzatzarakis, D. Kouretas, J. Liesivuori, A.K. Alegakis, D. Vynias, A.M. Tsatsakis, Multicomponent analysis of replacement liquids of electronic cigarettes using chromatographic techniques, J. Anal. Toxicol. 39 (2015) 262-269. otwiera się w nowej karcie
  14. J.
  15. J.A. Oh, H.S. Shin, Identification and quantification of several contaminated compounds in replacement liquids of electronic cigarettes by gas chromatography -mass spectrometry, J. Chromatogr. Sci. 53 (2015) 841-848. otwiera się w nowej karcie
  16. H.J. Kim, H.S. Shin, Determination of tobacco-specific nitrosamines in replacement liquids of electronic cigarettes by liquid chromatography -tandem mass spectrometry, J. Chromatogr. A 1291 (2013) 48-55. otwiera się w nowej karcie
  17. M.L. Trehy, W. Ye, M.E. Hadwiger, T.W. Moore, J.F. Allgire, J.T. Woodruff, S.S. Ahadi, J.C. Black, B.J. Westenberger, Analysis of electronic cigarette cartridges refill solutions, and smoke for nicotine and nicotine related impurities, J. Liq. Chromatogr. Relat. Technol. 34 (2011) 1442-1458. otwiera się w nowej karcie
  18. US Food and Drug Administration, Evaluation of e-cigarettes, 2009. otwiera się w nowej karcie
  19. P. Kubica, A. Wasik, A. Kot-Wasik, J. Namieśnik, An evaluation of sucrose as a possible contaminant in e-liquids for electronic cigarettes by hydrophilic interaction liquid chromatography -tandem mass spectrometry, Anal. Bioanal. Chem. 406 (2014) 3013-3018. otwiera się w nowej karcie
  20. K.E. Farsalinos, K.A. Kistler, G. Gillman, V. Vudris, Evaluation of electronic cigarette liquids and aerosol for the presence of selected inhalation toxins, Nicotine Tob. Res. 17 (2015) 168-174. otwiera się w nowej karcie
  21. P.A. Tierney, C.D. Karpinski, J.E. Brown, W. Luo, J.F. Pankow, Flavour chemicals in electronic cigarette fluids, Tob. Control 25 (2015) 10-15. otwiera się w nowej karcie
  22. M. Kucharska, W. Wesołowski, S. Czerczak, R. Soćko, Testing of the composition of e-cigarette liquids -manufacturer-declared vs. true contents in a selected series of products, Med. Pr. 67 (2016) 239-253. otwiera się w nowej karcie
  23. C. Hutzler, M. Paschke, S. Kruschinski, F. Henkler, J. Hahn, A. Luch, Chemical hazards present in liquids and vapors of electronic cigarettes, Arch. Toxicol. 88 (2014) 1295-1308. otwiera się w nowej karcie
  24. Guidance for Industry Bioanalytical Method Validation Guidance for Industry Bioanalytical Method Validation https://www.fda.gov/downloads/Drugs/ Guidance/ucm070107.pdf (Accessed 20.06.2017). otwiera się w nowej karcie
  25. C.C. Chan, H. Lam, Y.C. Lee, X.-M. Zhang, Analytical Method Validation and Instrument Performance Verification, John Wiley & Sons, Hoboken, 2004 (27 66;173-196). otwiera się w nowej karcie
  26. Guidance for Industry Q2 B Validation of Analytical Procedures: Methodology https://www.fda.gov/downloads/drugs/guidances/ucm073384.pdf (Accessed 20.06.2017). otwiera się w nowej karcie
  27. L. Rajski, A. Lozano, A. Uclés, C. Ferrer, A.R. Fernandez-Alba, Determination of pesticide residues in high oil vegetal commodities by using various multi-residue methods and clean-ups followed by liquid chromatography tandem mass spectrometry, J. Chromatogr. A 1304 (2013) 109-120. otwiera się w nowej karcie
  28. B.K. Matuszewski, M.L. Constanzer, C.M. Chavez-Eng, Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS, Anal. Chem. 75 (2003) 3019-3030. otwiera się w nowej karcie
  29. M. Wiergowski, J. Aszyk, M. Kaliszan, K. Wilczewska, J.S. Anand, A. Kot-Wasik, Z. Jankowski, Identification of novel psychoactive substances 25B-NBOMe and 4-CMC in biological material using HPLC-Q-TOF-MS and their quantification in blood using UPLC-MS/MS in case of severe intoxications, J. Chromatogr. B 1041 (2017) 1-10. otwiera się w nowej karcie
  30. M. Wiergowski, M.K. Woźniak, M. Kata, M. Biziuk, Determination of MDPBP in postmortem blood samples by gas chromatography coupled with mass spectrometry, Monatsh. Chem. 147 (2016) 1415-1421. otwiera się w nowej karcie
  31. M.M. Rahman, J. Jang, J.H. Park, A.M. Abd El-Aty, A.Y. Ko, J.H. Choi, A. Yang, K.H. Park, J.H. Shim, Determination of kresoxim-methyl and its thermolabile metabolites in pear utilizing pepper leaf matrix as a protectant using gas chromatography, J. Adv. Res. 5 (2014) 329-335. otwiera się w nowej karcie
  32. J. Namieśnik, P. Konieczka, Quality Assurance and Quality Control in the Analytical Chemical Laboratory, Wydawnictwo Naukowo-Techniczne, Warsaw, 2007, pp. 225-299.
  33. F. Buonocore, A.C.N.M. Gomes, S. Nabhani-Gebara, S.J. Barton, G. Calabrese, Labelling of electronic cigarettes: regulations and current practice, Tob. Control 26 (2016) 46-52. otwiera się w nowej karcie
Weryfikacja:
Politechnika Gdańska

wyświetlono 148 razy

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