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Detection of some volatile degradation products released during photoexposition of ranitidine in a solid state
Abstrakt
Ranitidine (RAN) is on top of the list of prescribed drugs, due to its popularity as a selective H2-receptor antagonist, which efficiently decreases the amount of acid produced in the stomach. RAN is not stable both in a solid state and in a solution, which creates manufacturing problems, requires appropriate storage conditions, and results in a short drug shelf-life. The aim of this work was to study the emission of volatile degradation products generated during photoexposition of ranitidine hydrochloride in a solid state. Significant changes in volatile profile ofirradiated RAN were detected using HS-SPME–GC–MS. Sixteen major peaks were noticed on the chromatograms of irradiated ranitidine and the structures of some compounds were elucidated, while the presence of acetaldoxime, thiazole, dimethylformamide, dimethylacetamide and 5-methylfurfural was confirmed by
means of the analysis of the authentic standards.
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Informacje szczegółowe
- Kategoria:
- Publikacja w czasopiśmie
- Typ:
- Publikacja w czasopiśmie
- Opublikowano w:
-
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
nr 76,
strony 177 - 182,
ISSN: 0731-7085 - Rok wydania:
- 2013
- DOI:
- Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) https://doi.org/10.1016/j.jpba.2012.12.019
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