Wyszukiwarka
Abstrakt
Direct electrical stimulation of the brain has emerged as a powerful treatment for multiple neurological diseases, and as a potential technique to enhance human cognition. Despite its application in a range of brain disorders, it remains unclear how stimulation of discrete brain areas affects memory performance and the underlying electrophysiological activities. Here, we investigated the effect of direct electrical stimulation in four brain regions known to support declarative memory: hippocampus (HP), parahippocampal region (PH) neocortex, prefrontal cortex (PF), and lateral temporal cortex (TC). Intracranial EEG recordings with stimulation were collected from 22 patients during performance of verbal memory tasks. We found that high γ (62–118 Hz) activity induced by word presentation was modulated by electrical stimulation. This modulatory effect was greatest for trials with “poor” memory encoding. The high γ modulation correlated with the behavioral effect of stimulation in a given brain region: it was negative, i.e., the induced high γ activity was decreased, in the regions where stimulation decreased memory performance, and positive in the lateral TC where memory enhancement was observed. Our results suggest that the effect of electrical stimulation on high γ activity induced by word presentation may be a useful biomarker for mapping memory networks and guiding therapeutic brain stimulation.
Cytowania
-
3 9
CrossRef
-
0
Web of Science
-
3 1
Scopus
Cytuj jako
Pełna treść
- Wersja publikacji
- Accepted albo Published Version
- DOI:
- Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.1523/ENEURO.0369-17.2018
- Licencja
-
otwiera się w nowej karcie
Słowa kluczowe
Informacje szczegółowe
- Kategoria:
- Publikacja w czasopiśmie
- Typ:
- artykuły w czasopismach
- Opublikowano w:
-
eNeuro
nr 5,
wydanie 1,
strony 1 - 14,
ISSN: 2373-2822 - Język:
- angielski
- Rok wydania:
- 2018
- DOI:
- Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.1523/eneuro.0369-17.2018
- Weryfikacja:
- Politechnika Gdańska
wyświetlono 81 razy
Publikacje, które mogą cię zainteresować
Closed-loop stimulation of temporal cortex rescues functional networks and improves memory
- Y. Ezzyat,
- P. A. Wanda,
- D. F. Levy
- + 19 autorów
Human memory enhancement through electrical stimulation in the temporal cortex
- M. T. Kucewicz,
- B. M. Berry,
- L. R. Miller
- + 17 autorów
Human verbal memory encoding is hierarchically distributed in a continuous processing stream
- M. T. Kucewicz,
- K. Saboo,
- B. M. Berry
- + 15 autorów
Direct brain stimulation modulates encoding states and memory performance in humans
- Y. Ezzyat,
- J. E. Kragel,
- J. F. Burke
- + 23 autorów