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Enhancing colloidal stability of nanodiamond via surface modification with dendritic molecules for optical sensing in physiological environments

Abstrakt

Pre-treatment of diamond surface in low-temperature plasma for oxygenation and in acids for carboxylation was hypothesized to promote the branching density of the hyperbranched glycidol polymer. This was expected to increase the homogeneity of the branching level and suppress interactions with proteins. As a result, composite nanodiamonds with reduced hydrodynamic diameters that are maintained in physiological environments were anticipated. Surfaces of 140-nm-sized nanodiamonds were functionalized with oxygen and carboxyl groups for grafting of hyperbranched dendritic polyglycerol via anionic ring-opening polymerization of glycidol. The modification was verified with Fourier-transform infrared spectroscopy and X-ray photoelectron spectroscopy. Dynamic light scattering investigated colloidal stability in pH-diverse (2–12) solutions, concentrated phosphate-buffered saline, and cell culture media. Thermogravimetric analysis of nanodiamonds-protein incubations examined non-specific binding. Fluorescence emission was tested across pH conditions. Molecular dynamics simulations modeled interparticle interactions in ionic solutions. The hyperbranched polyglycerol grafting increased colloidal stability of nanodiamonds across diverse pH, high ionic media like 10 × concentrated phosphate-buffered saline, and physiological media like serum and cell culture medium. The hyperbranched polyglycerol suppressed non-specific protein adsorption while maintaining intensive fluorescence of nanodiamonds regardless of pH. Molecular modelling indicated reduced interparticle interactions in ionic solutions correlating with the improved colloidal stability.

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Accepted albo Published Version
DOI:
Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.1016/j.jcis.2024.06.225
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Creative Commons: CC-BY otwiera się w nowej karcie

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Kategoria:
Publikacja w czasopiśmie
Typ:
artykuły w czasopismach
Opublikowano w:
JOURNAL OF COLLOID AND INTERFACE SCIENCE nr 675, strony 236 - 250,
ISSN: 0021-9797
Język:
amharski
Rok wydania:
2024
Opis bibliograficzny:
Głowacki M., Niedziałkowski P., Ryl J., Prześniak-Welenc M., Sawczak M., Prusik K., Ficek M., Janik M., Pyrchla K., Olewniczak M., Bojarski K., Czub J., Bogdanowicz R.: Enhancing colloidal stability of nanodiamond via surface modification with dendritic molecules for optical sensing in physiological environments// JOURNAL OF COLLOID AND INTERFACE SCIENCE -Vol. 675, (2024), s.236-250
DOI:
Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.1016/j.jcis.2024.06.225
Źródła finansowania:
Weryfikacja:
Politechnika Gdańska

wyświetlono 63 razy

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