Examination of epigenetic inhibitor zebularine in treatment of skin wounds in healthy and diabetic mice - Publikacja - MOST Wiedzy

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Examination of epigenetic inhibitor zebularine in treatment of skin wounds in healthy and diabetic mice

Abstrakt

DNA methyltransferase inhibitor zebularine was proven to induce regeneration in the ear pinna in mice. We utilized a dorsal skin wound model to further evaluate this epigenetic inhibitor in wound healing. Full-thickness excisional wounds were made on the dorsum of 2 and 10-month-old healthy BALB/c and 3 and 8-month-old diabetic (db/db) mice, followed by topical or intraperitoneal zebularine delivery. Depending on the strain, age, dose, and delivery, the zebularine treatments either had no effect or accelerated or delayed wound closure. In principle, zebularine applied topically moderately promoted wound closure in the healthy but markedly delayed in the diabetic mice, which was in line with decreased viability of cultured keratinocytes from diabetic patients exposed to zebularine. The histological analysis revealed an improvement in the architecture of restored skin in zebularine-treated mice, manifested as a distinct layered pattern resembling panniculus carnosus. The finding corresponds with the zebularine-mediated activation of the Wnt5a gene, an essential regulator of Wnt signaling, the pathway involved in hair follicle development, the process which in turn is connected with regenerative skin healing. Although zebularine did not remarkably accelerate wound healing, zebularine and other epigenetic inhibitors deserve further testing as potential drugs to improve the quality of restored skin.

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Informacje szczegółowe

Kategoria:
Publikacja w czasopiśmie
Typ:
artykuły w czasopismach
Opublikowano w:
Journal of Tissue Engineering and Regenerative Medicine nr 16, strony 1238 - 1248,
ISSN: 1932-6254
Język:
angielski
Rok wydania:
2022
Opis bibliograficzny:
Sass P., Sosnowski P., Kamińska J., Deptuła M., Skoniecka A., Zieliński J., Rodziewicz‐motowidło S., Pikuła M., Sachadyn P.: Examination of epigenetic inhibitor zebularine in treatment of skin wounds in healthy and diabetic mice// Journal of Tissue Engineering and Regenerative Medicine -Vol. 16,iss. 12 (2022), s.1238-1248
DOI:
Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.1002/term.3365
Źródła finansowania:
Weryfikacja:
Politechnika Gdańska

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