Growth inhibition of cultured cancer cells by Ribes nigrum leaf extract - Publikacja - MOST Wiedzy

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Growth inhibition of cultured cancer cells by Ribes nigrum leaf extract

Abstrakt

The present article includes data on the possible selective cytotoxic effect of extract of Ribes nigrum L. growing at high Armenian landscape. For this purpose, different non-cancer (microglial BV-2 wild type (Wt), acyl-CoA oxidase 1 (ACOX1) deficient (Acox1-/-) and cancer (human colon adenocarcinoma HT29 and human breast cancer MCF7) cell lines were applied. R. nigrum leaf ethanol extract showed a growth inhibition effect towards HT29 and MCF7 cells started from 6 h of treatment at the concentration of 0.5 mg/mL DW. The lowest concentration (0.125 mg/mL DW) of the investigated extract expressed cytotoxicity after 72 hours following cancer cell treatment. In contrast to the cancer cells, in the case of the tested non-cancer cells, cytotoxic effect was not observed at the applied concentrations. The extract sub-cytotoxic concentration, in this case, was reported to be the 1 mg/mL DW. Further investigations are needed to confirm the selective cytotoxicity and possible action mechanisms of the leaf extract of R. nigrum.

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Informacje szczegółowe

Kategoria:
Publikacja w czasopiśmie
Typ:
artykuły w czasopismach
Opublikowano w:
AIMS Biophysics nr 9, strony 282 - 293,
ISSN: 2377-9098
Język:
angielski
Rok wydania:
2022
Opis bibliograficzny:
Ginovyan M., Bartoszek-Pączkowska A., Koss-Mikołajczyk I., Kusznierewicz B., Andreoletti P., Cherkaoui-Malki M., Sahakyan N.: Growth inhibition of cultured cancer cells by Ribes nigrum leaf extract// AIMS Biophysics -,iss. 9 (2022), s.282-293
DOI:
Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.3934/biophy.2022024
Źródła finansowania:
  • COST_FREE
Weryfikacja:
Politechnika Gdańska

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