Higher platelet counts correlate to tumour progression and can be induced by intratumoural stroma in non-metastatic breast carcinomas - Publikacja - MOST Wiedzy

Twoje konto

zaloguj

Wyszukiwarka

Higher platelet counts correlate to tumour progression and can be induced by intratumoural stroma in non-metastatic breast carcinomas

Abstrakt

Background Platelets support tumour progression. However, their prognostic significance and relation to circulating tumour cells (CTCs) in operable breast cancer (BrCa) are still scarcely known and, thus, merit further investigation. Methods Preoperative platelet counts (PCs) were compared with clinical data, CTCs, 65 serum cytokines and 770 immune-related transcripts obtained using the NanoString technology. Results High normal PC (hPC; defined by the 75th centile cut-off) correlated with an increased number of lymph node metastases and mesenchymal CTCs in the 70 operable BrCa patients. Patients with hPC and CTC presence revealed the shortest overall survival compared to those with no CTC/any PC or even CTC/normal PC. Adverse prognostic impact of hPC was observed only in the luminal subtype, when 247 BrCa patients were analysed. hPC correlated with high content of intratumoural stroma, specifically its phenotype related to CD8+ T and resting mast cells, and an increased concentration of cytokines related to platelet activation or even production in bone marrow (i.e. APRIL, ENA78/CXCL5, HGF, IL16, IL17a, MDC/CCL22, MCP3, MMP1 and SCF). Conclusions Preoperative platelets evaluated alone and in combination with CTCs have prognostic potential in non-metastatic BrCa and define patients at the highest risk of disease progression, putatively benefiting from anti-platelet therapy.

Cytowania

  • 4

    CrossRef

  • 0

    Web of Science

  • 6

    Scopus

Autorzy (12)

Cytuj jako

Pełna treść

pełna treść publikacji nie jest dostępna w portalu

Słowa kluczowe

Informacje szczegółowe

Kategoria:
Publikacja w czasopiśmie
Typ:
artykuły w czasopismach
Opublikowano w:
BRITISH JOURNAL OF CANCER nr 126, strony 464 - 471,
ISSN: 0007-0920
Język:
angielski
Rok wydania:
2022
Opis bibliograficzny:
Bednarz-Knoll N., Popęda M., Kryczka T., Kozakiewicz B., Pogoda K., Szade J., Markiewicz A., Strzemecki D., Kalinowski L., Skokowski J., Liu J., Żaczek A.: Higher platelet counts correlate to tumour progression and can be induced by intratumoural stroma in non-metastatic breast carcinomas// BRITISH JOURNAL OF CANCER -Vol. 126, (2022), s.464-471
DOI:
Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.1038/s41416-021-01647-9
Źródła finansowania:
  • Publikacja bezkosztowa
Weryfikacja:
Politechnika Gdańska

wyświetlono 104 razy

Publikacje, które mogą cię zainteresować

Cytokine IL6, but not IL-1β, TNF-α and NF-κB is increased in paediatric cancer patients

2023

Computed aided system for separation and classification of the abnormal erythrocytes in human blood

2017

c-Myc inhibition and p21 modulation contribute to unsymmetrical bisacridines-induced apoptosis and senescence in pancreatic cancer cells

2024

RAGE as a Novel Biomarker for Prostate Cancer: A Systematic Review and Meta-Analysis

  • C. C. Applegate,
  • M. B. Nelappana,
  • E. A. Nielsen
  • + 3 autorów
2023
Meta Tagi