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Abstrakt
Glycosaminoglycans are a wide class of biopolymers showing great lubricating properties due to their structure and high affinity to water. Two of them, hyaluronic acid and chondroitin sulfate, play an important role in articular cartilage lubrication. In this work, we present results of the all-atom molecular dynamics simulations of both molecules placed in water-based solution. To mimic changes of the physiological conditions, especially temperature, of the synovial fluid in joints under successive load (e.g., walking, jogging, jumping), simulations have been performed at different physiological temperatures in the range of 300 to 320 Kelvin (normal intra-articular temperature is305K).The stability of the biopolymeric network at equilibrium(isothermal and isobaric) conditions has been studied. To understand the process of physical crosslinking, the dynamics of intra- and intermolecular hydrogen bonds forming and breaking have been studied. The results show that following addition of chondroitin sulfate, hyaluronan creates more intermolecular hydrogen bonds than when in homogeneous solution. The presence of chondroitin in a hyaluronan network is beneficialas it may increase its stability. Presented data show hyaluronic acid and chondroitin sulfate as viscosity modifiers related to their crosslinking properties in different physicochemical conditions.
Cytowania
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Autorzy (5)
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Tomasz Andrysiak dr inż.
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Piotr Bełdowski dr
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Jacek Siódmiak dr
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Damian Ledziński dr inż.
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Pełna treść
- Wersja publikacji
- Accepted albo Published Version
- Licencja
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otwiera się w nowej karcie
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Informacje szczegółowe
- Kategoria:
- Publikacja w czasopiśmie
- Typ:
- artykuł w czasopiśmie wyróżnionym w JCR
- Opublikowano w:
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Polymers
nr 10,
strony 1 - 11,
ISSN: 2073-4360 - Język:
- angielski
- Rok wydania:
- 2018
- Opis bibliograficzny:
- Andrysiak T., Bełdowski P., Siódmiak J., Weber P., Ledziński D.: Hyaluronan-Chondroitin Sulfate Anomalous Crosslinking Due to Temperature Changes// Polymers. -Vol. 10, nr. 5 (2018), s.1-11
- DOI:
- Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.3390/polym10050560
- Weryfikacja:
- Politechnika Gdańska
wyświetlono 152 razy
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