Hydration of Simple Model Peptides in Aqueous Osmolyte Solutions - Publikacja - MOST Wiedzy

Wyszukiwarka

Hydration of Simple Model Peptides in Aqueous Osmolyte Solutions

Abstrakt

The biology and chemistry of proteins and peptides are inextricably linked with water as the solvent. The reason for the high stability of some proteins or uncontrolled aggregation of others may be hidden in the properties of their hydration water. In this study, we investigated the effect of stabilizing osmolyte–TMAO (trimethylamine N-oxide) and destabilizing osmolyte–urea on hydration shells of two short peptides, NAGMA (N-acetyl-glycine-methylamide) and diglycine, by means of FTIR spectroscopy and molecular dynamics simulations. We isolated the spectroscopic share of water molecules that are simultaneously under the influence of peptide and osmolyte and determined the structural and energetic properties of these water molecules. Our experimental and computational results revealed that the changes in the structure of water around peptides, caused by the presence of stabilizing or destabilizing osmolyte, are significantly different for both NAGMA and diglycine. The main factor determining the influence of osmolytes on peptides is the structural-energetic similarity of their hydration spheres. We showed that the chosen peptides can serve as models for various fragments of the protein surface: NAGMA for the protein backbone and diglycine for the protein surface with polar side chains.

Cytowania

  • 5

    CrossRef

  • 0

    Web of Science

  • 5

    Scopus

Cytuj jako

Słowa kluczowe

Informacje szczegółowe

Kategoria:
Publikacja w czasopiśmie
Typ:
artykuły w czasopismach
Opublikowano w:
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES nr 22,
ISSN: 1661-6596
Język:
angielski
Rok wydania:
2021
Opis bibliograficzny:
Panuszko A., Pieloszczyk M., Kuffel A., Jacek K., Biernacki K., Demkowicz S., Stangret J., Bruździak P.: Hydration of Simple Model Peptides in Aqueous Osmolyte Solutions// INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES -Vol. 22,iss. 17 (2021), s.9350-
DOI:
Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.3390/ijms22179350
Źródła finansowania:
Weryfikacja:
Politechnika Gdańska

wyświetlono 136 razy

Publikacje, które mogą cię zainteresować

Meta Tagi