Wyszukiwarka
Hydroperoxyl radical and formic acid formation from common DNA stabilizers upon low energy electron attachment
Abstrakt
2-Amino-2-(hydroxymethyl)-1,3-propanediol (TRIS) and ethylenediaminetetraacetic acid (EDTA) are key components of biological buffers and are frequently used as DNA stabilizers in irradiation studies. Such surface or liquid phase studies are done with the aim to understand the fundamental mechanisms of DNA radiation damage and to improve cancer radiotherapy. When ionizing radiation is used, abundant secondary electrons are formed during the irradiation process, which are able to attach to the molecular compounds present on the surface. In the present study we experimentally investigate low energy electron attachment to TRIS and methyliminodiacetic acid (MIDA), an analogue of EDTA, supported by quantum chemical calculations. The most prominent dissociation channel for TRIS is through hydroperoxyl radical formation, whereas the dissociation of MIDA results in the formation of formic and acetic acid. These compounds are well-known to cause DNA modifications, like strand breaks. The present results indicate that buffer compounds may not have an exclusive protecting effect on DNA as suggested previously.
Cytowania
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Autorzy (8)
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Anita Ribar
- Leopold Franzens University of Innsbruck Institute for Ion Physics and Applied Physics and Center of Molecular Biosciences Innsbruck
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Stefan Huber
- Leopold Franzens University of Innsbruck Institute for Basic Sciences in Engineering Science,
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Katrin Tanzer
- Leopold Franzens University of Innsbruck Institute for Ion Physics and Applied Physics and Center of Molecular Biosciences Innsbruck
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Michael Neustetter
- Leopold Franzens University of Innsbruck Institute for Ion Physics and Applied Physics and Center of Molecular Biosciences Innsbruck
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Robin Schürmann
- Institute of Chemistry-Physical Chemistry University of Potsdam
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Ilko Bald
- Institute of Chemistry-Physical Chemistry University of Potsdam
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Stephan Denifl
- Leopold Franzens University of Innsbruck Institute for Ion Physics and Applied Physics and Center of Molecular Biosciences Innsbruck
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Informacje szczegółowe
- Kategoria:
- Publikacja w czasopiśmie
- Typ:
- artykuł w czasopiśmie wyróżnionym w JCR
- Opublikowano w:
-
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
nr 20,
wydanie 8,
strony 5578 - 5585,
ISSN: 1463-9076 - Język:
- angielski
- Rok wydania:
- 2018
- Opis bibliograficzny:
- Ribar A., Huber S., Śmiałek-Telega M., Tanzer K., Neustetter M., Schürmann R., Bald I., Denifl S.: Hydroperoxyl radical and formic acid formation from common DNA stabilizers upon low energy electron attachment// PHYSICAL CHEMISTRY CHEMICAL PHYSICS. -Vol. 20, iss. 8 (2018), s.5578-5585
- DOI:
- Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.1039/c7cp07697e
- Weryfikacja:
- Politechnika Gdańska
wyświetlono 172 razy
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