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Investigation of an elutable N-propylphosphonic acid chitosan derivative composition with a chitosan matrix prepared from carbonic acid solution
Abstrakt
Porous chitosan composites using CO2 dissolution procedure and including water soluble N-propylphosphonic chitosan derivative (p-CHI) were obtained and characterized. In contrast to the control material, composites containing modified chitosan distinguished by a rapid moisture absorption and good adhesion to the skin. The FTIR analysis confirmed the presence of propylphosphonic group in the structure of the polymer. The porosity of the materials was in the range 55–77% and decreased with increasong amount of modified chitosan in materials. Solubility of composites was dependent on the content of p-CHI in scaffolds (40%, 25% and 15%) and reached values 11%, 9% and 6,5%, respectively. The values of other parameters like swelling degree (30 g/g) good antioxidant and antimicrobial properties (almost 100% reduction of S.aureus, E.coli and C. albicans growth) and low in vitro cytotoxicity against fibroblasts were highly advantageous for possible biomedical applications of the composites.
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Autorzy (6)
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Jakub Szwacki
- Cambridge Innovation Center, Broadway FL14, Cambridge, MA 02142, United States of America
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- Wersja publikacji
- Accepted albo Published Version
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Informacje szczegółowe
- Kategoria:
- Publikacja w czasopiśmie
- Typ:
- artykuł w czasopiśmie wyróżnionym w JCR
- Opublikowano w:
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CARBOHYDRATE POLYMERS
nr 179,
strony 196 - 206,
ISSN: 0144-8617 - Język:
- angielski
- Rok wydania:
- 2018
- Opis bibliograficzny:
- Mania S., Tylingo R., Augustin E., Gucwa K. M., Szwacki J., Staroszczyk H.: Investigation of an elutable N-propylphosphonic acid chitosan derivative composition with a chitosan matrix prepared from carbonic acid solution// CARBOHYDRATE POLYMERS. -Vol. 179, (2018), s.196-206
- DOI:
- Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.1016/j.carbpol.2017.09.082
- Weryfikacja:
- Politechnika Gdańska
wyświetlono 279 razy