Nanosilver-loaded PMMA bone cement doped with different bioactive glasses – evaluation of cytocompatibility, antibacterial activity, and mechanical properties - Publikacja - MOST Wiedzy

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Nanosilver-loaded PMMA bone cement doped with different bioactive glasses – evaluation of cytocompatibility, antibacterial activity, and mechanical properties

Abstrakt

Nanosilver-loaded PMMA bone cement (BC-AgNp) is a novel cement developed as a replacement for conventional cements. Despite favorable properties and antibacterial activity, BC-AgNp still lacks biodegradability and bioactivity. Hence, we investigated the doping with bioactive glasses (BGs) to create a new bioactive BC characterized by time-varying porosity and gradual release of nanosilver. The BC Cemex was used as the base material and modified simultaneously with the AgNp and BGs: melted 45S5 and 13-93B3 glasses with various particles size and sol-gel derived SiO2/CaO microparticles. The effect of BGs addition was examined by microscopic analysis, an assessment of setting parameters, wettability, FTIR and UV-VIS spectroscopy, mechanical testing, hemo- and cytocompatibility and antibacterial efficiency studies. The results show that it is possible to incorporate various BGs into BC-AgNp that lead to different properties depending on the type and size of BGs. The smaller particles of melted BGs showed higher porosity and better antibacterial properties with the moderate deterioration of mechanical properties. The sol-gel derived BGs, however, displayed a tendency for agglomeration and random distribution in BC-AgNp. The BGs with greater solubility more efficiently improves the antibacterial properties of BC-AgNp. Besides, the unreacted MMA monomer release could negatively influence the cellular response. Despite that, the cements doped with different bioactive glasses are suitable for medical applications.

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Wersja publikacji
Accepted albo Published Version
Licencja
Copyright (2021 The Royal Society of Chemistry)

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Informacje szczegółowe

Kategoria:
Publikacja w czasopiśmie
Typ:
artykuły w czasopismach
Opublikowano w:
Biomaterials Science nr 9, strony 3112 - 3126,
ISSN: 2047-4830
Język:
angielski
Rok wydania:
2021
Opis bibliograficzny:
Wekwejt M., Chen S., Kaczmarek B., Nadolska M., Łukowicz K., Pałubicka A., Michno A., Osyczka A. M., Michalek M., Zieliński A.: Nanosilver-loaded PMMA bone cement doped with different bioactive glasses – evaluation of cytocompatibility, antibacterial activity, and mechanical properties// Biomaterials Science -Vol. 9,iss. 8 (2021), s.3112-3126
DOI:
Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.1039/d1bm00079a
Weryfikacja:
Politechnika Gdańska

wyświetlono 105 razy

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