Natural carbon-based quantum dots and their applications in drug delivery: A review

Akhila Nair; Józef Tadeusz Haponiuk; Sabu Thomas; Sreeraj Gopi

doi:10.1016/j.biopha.2020.110834

Natural carbon-based quantum dots and their applications in drug delivery: A review

Abstrakt

Natural carbon based quantum dots (NCDs) are an emerging class of nanomaterials in the carbon family. NCDs have gained immense acclamation among researchers because of their abundance, eco-friendly nature, aqueous solubility, the diverse functionality and biocompatibility when compared to other conventional carbon quantum dots (CDs).The presence of different functional groups on the surface of NCDs such as thiol, carboxyl, hydroxyl, etc., provides improved quantum yield, physicochemical and optical properties which promote bioimaging, sensing, and drug delivery. This review provides comprehensive knowledge about NCDs for drug delivery applications by outlining the source and rationale behind NCDs, different routes of synthesis of NCDs and the merits of adopting each method. Detailed information regarding the mechanism behind the optical properties, toxicological profile including biosafety and biodistribution of NCDs that are favourable for drug delivery are discussed. The drug delivery applications of NCDs particularly as sensing and real-time tracing probe, antimicrobial, anticancer, neurodegenerative agents are reviewed. The clinical aspects of NCDs are also reviewed as an initiative to strengthen the case of NCDs as potent drug delivery agents.

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Autorzy (4)

Akhila Nair mgr
Józef Tadeusz Haponiuk (dawniej: Józef Haponiuk) prof. dr hab. inż.
Sabu Thomas Profesor
Sreeraj Gopi

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Wersja publikacji: Accepted albo Published Version
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Informacje szczegółowe

Kategoria:: Publikacja w czasopiśmie
Typ:: artykuły w czasopismach
Opublikowano w:: BIOMEDICINE & PHARMACOTHERAPY nr 132,
ISSN: 0753-3322
Język:: angielski
Rok wydania:: 2020
Opis bibliograficzny:: Nair A., Haponiuk J., Thomas S., Gopi S.: Natural carbon-based quantum dots and their applications in drug delivery: A review// BIOMEDICINE & PHARMACOTHERAPY -Vol. 132, (2020), s.110834-
DOI:: Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.1016/j.biopha.2020.110834
Weryfikacja:: Politechnika Gdańska