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Abstrakt
The gut microbiome has been increasingly understood to play a critical role in carcinogenesis and cancer disease progression. The most recent research advancements have shown that different tools of microbiota manipulation contribute to gut microbiome–immune–oncology axis modulation, offering exciting opportunities for targeted interventions aimed at improving the efficacy of established anti-cancer therapy. Postbiotics are a new entry among the biotics showing beneficial effects on human health while not requiring living cells to obtain the health effect and therefore not subjected to food safety rules for live microorganisms. Postbiotics are recently defined as the “preparation of inanimate microorganisms and/or their components that confers a health benefit on the host” and have gradually become the focus of the scientific community. Since the beginning of research on this topic, numerous studies about postbiotics have been proven to strengthen the gut barrier, reduce inflammation, and promote antimicrobial activity. However, research on the potential application of cancer therapy is still at the early stages of its efforts to uncover all the secrets surrounding postbiotics. This review aims to increase our understanding of the anti-cancer effect of postbiotics throughout a “bibliographic journey” on the biological activity of their components, including exopolysaccharides, cell wall fragments, tryptophan metabolites, enzymes, bacterial lysates, extracellular vesicles, and short-chain fatty acids, highlighting their perspective as a new supportive therapeutic method of treatment and identifying the literature gaps where further research is needed.
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2
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Autorzy (10)
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Anna Kudra
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Karolina Kaźmierczak-Siedlecka
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Bartosz Kamil Sobocki
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Damian Muszyński
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Joanna Polom
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Ludovico Carbone
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Luigi Marano
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Franco Roviello
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Ewa Stachowska
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Pełna treść
- Wersja publikacji
- Accepted albo Published Version
- DOI:
- Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.3389/fmicb.2023.1182547
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Informacje szczegółowe
- Kategoria:
- Publikacja w czasopiśmie
- Typ:
- artykuły w czasopismach
- Opublikowano w:
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Frontiers in Microbiology
nr 14,
strony 1 - 10,
ISSN: 1664-302X - Język:
- angielski
- Rok wydania:
- 2023
- Opis bibliograficzny:
- Kudra A., Kaźmierczak-Siedlecka K., Sobocki B. K., Muszyński D., Polom J., Carbone L., Marano L., Roviello F., Kalinowski L., Stachowska E.: Postbiotics in oncology: science or science fiction?// Frontiers in Microbiology -Vol. 14, (2023), s.1-10
- DOI:
- Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.3389/fmicb.2023.1182547
- Źródła finansowania:
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- This research was funded by the Pomeranian Medical University in Szczecin, Poland (Project number: WNoZ 330- 01/S/2022). Fee was partially covered by Medical University of Gdansk, Poland
- Weryfikacja:
- Politechnika Gdańska
wyświetlono 55 razy
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