Procognitive activity of nitric oxide inhibitors and donors in animal models - Publikacja - MOST Wiedzy

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Procognitive activity of nitric oxide inhibitors and donors in animal models

Abstrakt

Nitric oxide is a small gaseous molecule that plays important roles in the majority of biological functions. Impairments of NO-related pathways contribute to the majority of neurological disorders, such as Alzheimer’s disease (AD), and mental disorders, such as schizophrenia. Cognitive decline is one of the most serious impairments accompanying both AD and schizophrenia. In the present study, the activities of NO donors, slow (spermine NONOate) or fast (DETANONOate) releasers, and selective inhibitor of neuronal nitric oxide synthase N(ω)-propyl-L-arginine (NPLA) were investigated in pharmacological models of schizophrenia and AD. Cognitive impairments were induced by administration of MK- 801 or scopolamine and were measured in novel object recognition (NOR) and Y-maze tests. The compounds were investigated at doses of 0.05–0.5 mg/kg. The dose-dependent effectiveness of all the compounds was observed in the NOR test, while only the highest doses of spermine NONOate and NPLA were active in the Ymaze test. DETANONOate was not active in the Y-maze test. The impact of the investigated compounds on motor coordination was tested at doses of 0.5 and 1 mg/kg. Only NPLA at a dose of 1 mg/kg slightly disturbed motor coordination in animals.

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Kategoria:
Publikacja w czasopiśmie
Typ:
artykuły w czasopismach
Opublikowano w:
NITRIC OXIDE-BIOLOGY AND CHEMISTRY nr 119, strony 29 - 40,
ISSN: 1089-8603
Język:
angielski
Rok wydania:
2022
Opis bibliograficzny:
Cieślik P., Kalinowski L., Wierońska J. M.: Procognitive activity of nitric oxide inhibitors and donors in animal models// NITRIC OXIDE-BIOLOGY AND CHEMISTRY -Vol. 119, (2021), s.29-40
DOI:
Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.1016/j.niox.2021.12.003
Weryfikacja:
Politechnika Gdańska

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