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Abstrakt
The structure of B-DNA, the physiological form of the DNA molecule, has been a central topic in biology, chemistry and physics. Far from uniform and rigid, the double helix was revealed as a flexible and structurally polymorphic molecule. Conformational changes that lead to local and global changes in the helix geometry are mediated by a complex choreography of base and backbone rearrangements affecting the ability of the B-DNA to recognize ligands and consequently on its functionality. In this sense, the knowledge obtained from the sequence-dependent structural properties of B-DNA has always been thought crucial to rationalize how ligands and, most notably, proteins recognize B-DNA and modulate its activity, i.e. the structural basis of gene regulation. Honouring the anniversary of the first high-resolution X-ray structure of a B-DNA molecule, in this contribution, we present the most important discoveries of the last 40 years on the sequence-dependent structural and dynamical properties of B-DNA, from the early beginnings to the current frontiers in the field.
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Autorzy (26)
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Gabriela da Rosa
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Leandro Grille
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Victoria Calzada
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Katya Ahmad
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Juan Pablo Arcon
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Federica Battistini
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Genís Bayarri
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Thomas Bishop
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Paolo Carloni
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Thomas Cheatham III
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Rosana Collepardo-Guevara
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Jorge R. Espinosa
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Rodrigo Galindo-Murillo
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Sarah A. Harris
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Adam Hospital
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Charles Laughton
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John H. Maddocks
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Agnes Noy
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Modesto Orozco
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Marco Pasi
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Alberto Pérez
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Daiva Petkevičiūtė-Gerlach
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Rahul Sharma
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Ran Sun
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Pablo D. Dans
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Pełna treść
- Wersja publikacji
- Accepted albo Published Version
- DOI:
- Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.1007/s12551-021-00893-8
- Licencja
- Copyright (2021 International Union for Pure and Applied Biophysics (IUPAB) and Springer-Verlag GmbH Germany, part of Springer Nature)
Słowa kluczowe
Informacje szczegółowe
- Kategoria:
- Publikacja w czasopiśmie
- Typ:
- artykuły w czasopismach
- Opublikowano w:
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Biophysical Reviews
nr 13,
strony 995 - 1005,
ISSN: 1867-2450 - Język:
- angielski
- Rok wydania:
- 2021
- Opis bibliograficzny:
- Da Rosa G., Grille L., Calzada V., Ahmad K., Arcon J. P., Battistini F., Bayarri G., Bishop T., Carloni P., Cheatham Iii T., Collepardo-Guevara R., Czub J., Espinosa J. R., Galindo-Murillo R., Harris S. A., Hospital A., Laughton C., Maddocks J. H., Noy A., Orozco M., Pasi M., Pérez A., Petkevičiūtė-Gerlach D., Sharma R., Sun R., Dans P. D.: Sequence-dependent structural properties of B-DNA: what have we learned in 40 years?// Biophysical Reviews -Vol. 13,iss. 6 (2021), s.995-1005
- DOI:
- Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.1007/s12551-021-00893-8
- Weryfikacja:
- Politechnika Gdańska
wyświetlono 26 razy
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