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Serum bisphenol A concentrations correlate with serum testosterone levels in women with polycystic ovary syndrome

Abstrakt

The aim of this study was to determine serum bisphenol A (BPA) concentrations using high performance liquid chromatography with tandem mass spectrometry (HPLC–MS/MS) in women with polycystic ovary syndrome (PCOS) (n=106, age range 18–40 yrs) and to evaluate its potential impact on their hormonal and metabolic profile. The control group consisted of age- and BMI-matched 80 eumenorrheic women with no clinical or biochemical hyperandrogenism. Our results showed that women with PCOS had significantly higher serum BPA concentrations than healthy controls (geometric mean and [95% CI]: 0.202 ng/mL [0.150; 0.255] vs. 0.154 ng/ mL [0.106; 0.201], P=0.035), which correlated positively with serum total testosterone (TST) (R=0.285, P=0.004) and the free androgen index (FAI) (R=0.196, P=0.049). There were no significant correlations between serum BPA and BMI, waist circumference, serum glucose, insulin and lipids. These results point to the potential role of BPA in the pathogenesis of the ovarian hyperandrogenism in women with PCOS.

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Wersja publikacji
Accepted albo Published Version
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Creative Commons: CC-BY-NC-ND otwiera się w nowej karcie

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Kategoria:
Publikacja w czasopiśmie
Typ:
artykuł w czasopiśmie wyróżnionym w JCR
Opublikowano w:
REPRODUCTIVE TOXICOLOGY nr 82, strony 32 - 37,
ISSN: 0890-6238
Język:
angielski
Rok wydania:
2018
Opis bibliograficzny:
Konieczna A., Rachoń D., Owczarek K., Kubica P., Kowalewska A., Kudłak B., Wasik A., Namieśnik J.: Serum bisphenol A concentrations correlate with serum testosterone levels in women with polycystic ovary syndrome// REPRODUCTIVE TOXICOLOGY. -Vol. 82, (2018), s.32-37
DOI:
Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.1016/j.reprotox.2018.09.006
Weryfikacja:
Politechnika Gdańska

wyświetlono 137 razy

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