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Abstrakt
In the small intestine the nature of the environment leads to a highly heterogeneous mucus layer primarily composed of the MUC2 mucin. We set out to investigate whether the soluble dietary fibre sodium alginate could alter the permeability of the mucus layer. The alginate was shown to freely diffuse into the mucus and to have minimal effect on the bulk rheology when added at concentrations below 0.1%. Despite this lack of interaction between the mucin and alginate, the addition of alginate had a marked effect on the diffusion of 500 nm probe particles, which decreased as a function of increasing alginate concentration. Finally, we passed a protein stabilised emulsion through a simulation of oral, gastric and small intestinal digestion. We subsequently showed that the addition of 0.1% alginate to porcine intestinal mucus decreased the diffusion of fluorescently labelled lipid present in the emulsion digesta. This reduction may be sufficient to reduce problems associated with high rates of lipid absorption such as hyperlipidaemia.
Cytowania
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Web of Science
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Scopus
Autorzy (8)
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Alan Mackie
- Norwich Research Park Institute of Food Research
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Kristi Aarak
- UMB – Norwegian University of Life Sciences Department of Chemistry, Biotechnology and Food Science (IKBM)
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Neil Rigby
- Norwich Research Park Institute of Food Research
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Roger Parker
- Norwich Research Park Institute of Food Research
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Guy Channell
- University of Nottingham National Centre for Macromolecular Hydrodynamics
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Stephen Harding
- University of Nottingham National Centre for Macromolecular Hydrodynamics
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Balazs Bajka
- Norwich Research Park Institute of Food Research
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Pełna treść
- Wersja publikacji
- Accepted albo Published Version
- DOI:
- Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.1016/j.foodhyd.2015.08.004
- Licencja
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otwiera się w nowej karcie
Słowa kluczowe
Informacje szczegółowe
- Kategoria:
- Publikacja w czasopiśmie
- Typ:
- artykuł w czasopiśmie wyróżnionym w JCR
- Opublikowano w:
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FOOD HYDROCOLLOIDS
nr 52,
strony 749 - 755,
ISSN: 0268-005X - Język:
- angielski
- Rok wydania:
- 2016
- Opis bibliograficzny:
- Mackie A., Macierzanka A., Aarak K., Rigby N., Parker R., Channell G., Harding S., Bajka B.: Sodium alginate decreases the permeability of intestinal mucus// FOOD HYDROCOLLOIDS. -Vol. 52, (2016), s.749-755
- DOI:
- Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.1016/j.foodhyd.2015.08.004
- Weryfikacja:
- Politechnika Gdańska
wyświetlono 120 razy
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