Spectroscopic and cytotoxic characteristics of (p-cymene)Ru(II) complexes with bidentate coumarins and density functional theory comparison with selected Pd(II) complexes
This paper presents the synthesis of two new (p-cymene)-ruthenium(II) complexes with the bidentate coumarin ligands. Both complexes were characterized by FTIR spectroscopy, 1H NMR, 13C NMR, MS, elemental analysis and DFT calculations. The X-ray structure of complex 3a was also solved. The cytotoxic properties of both complexes were examined on human leukemia NALM-6 and HL-60 cells and melanoma WM-115 cells. The complexes possess higher cytotoxic activity than the ligands, The results of DFT calculations performed at the BP86-D3/QZ4P level for Ru(II) complexes and Pd(II) complexes with the same ligands indicate that Pd(II) complexes are more lipophilic. Moreover the RP-TLC-Based Lipophilicity assessment was also performed.
Anna Skoczynska, Karin Lux, Peter Mayer, Ingo-Peter Lorenz, Urszula Krajewska, Marek Rozalski, Anna Dołęga, Elzbieta Budzisz. (2017). Spectroscopic and cytotoxic characteristics of (p-cymene)Ru(II) complexes with bidentate coumarins and density functional theory comparison with selected Pd(II) complexes. Inorganica Chimica Acta, 456, 105-112. https://doi.org/10.1016/j.ica.2016.10.036
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